Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Associated Therapies: -

Clinical Trials

Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.

Not Applicable

Completed

Conditions: Adverse Effect

Interventions: Drug: Normal saline
Drug: Norepinephrine

First Posted Date: 2020-09-21

Last Posted Date: 2023-06-13

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 180

Registration Number: NCT04556370

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia

Not Applicable

Completed

Conditions: Adverse Effect

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2020-09-21

Last Posted Date: 2021-11-29

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 138

Registration Number: NCT04556357

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Dopamine Versus Norepinephrine Under General Anesthesia

Phase 3

Completed

Conditions: Congenital Heart Disease
Infant
Hemodynamic Instability
Anesthesia

Interventions: Drug: norepinephrine
Drug: dopamine

First Posted Date: 2020-09-02

Last Posted Date: 2021-10-22

Lead Sponsor: Children's Hospital of Fudan University

Target Recruit Count: 60

Registration Number: NCT04536194

Locations: 🇨🇳
Children's Hospital of Fudan University, Shanghai, Shanghai, China

The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury

Conditions: Fibrinolytic Hemorrhage, Acquired
Brain Injuries, Traumatic
Coagulopathy
Coagulation Defect; Acquired
Coagulation Defect; Bleeding

Interventions: Drug: noradrenaline

First Posted Date: 2020-08-17

Last Posted Date: 2020-08-17

Lead Sponsor: University Medical Centre Ljubljana

Target Recruit Count: 60

Registration Number: NCT04515420

Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

Phase 3

Active, not recruiting

Conditions: Cardiac Disease

Interventions: Drug: Norepinephrine
Drug: Vasopressin

First Posted Date: 2020-08-06

Last Posted Date: 2024-02-09

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 160

Registration Number: NCT04501861

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Prehospital Norepinephrine and Early Mortality in Traumatic Shock

Completed

Conditions: Hypotension and Shock
Traumatic Brain Injury
Hemorrhagic Shock
Traumatic Shock

Interventions: Drug: Norepinephrine

First Posted Date: 2020-08-04

Last Posted Date: 2022-02-10

Lead Sponsor: University of Maryland, Baltimore

Target Recruit Count: 2164

Registration Number: NCT04497155

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Early Phase 1

Recruiting

Conditions: Healthy
Vasoconstriction
Vasodilation
Obesity

Interventions: Other: Hypoxia Exposure
Drug: Phenylephrine
Drug: Dexmedetomidine
Drug: Phentolamine
Drug: Norepinephrine

First Posted Date: 2020-06-18

Last Posted Date: 2024-05-03

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 104

Registration Number: NCT04436731

Locations: 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States

The Effect of Norepinephrine on Cardiac Output in Patients Undergoing Liver Transplant .

Not Applicable

Completed

Conditions: Liver Transplantation

Interventions: Drug: Noradrenaline

First Posted Date: 2020-05-06

Last Posted Date: 2021-11-09

Lead Sponsor: Cairo University

Target Recruit Count: 31

Registration Number: NCT04376281

Locations: 🇪🇬
kasr El Ainy school of medicine, Cairo, Egypt

Norepinephrine for Hypotension in Cesarean Section

Not Applicable

Completed

Conditions: Hypotension
Cesarean Section

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2020-04-29

Last Posted Date: 2023-01-04

Lead Sponsor: Assiut University

Target Recruit Count: 180

Registration Number: NCT04367103

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Norepinephrine Infusion During Cardiopulmonary Bypass

Not Applicable

Completed

Conditions: Cardiac Surgery
Cardiopulmonary Bypass

Interventions: Drug: Placebo
Drug: Norepinephrine
Other: Increase infusion rate
Other: Decrease infusion rate

First Posted Date: 2020-03-18

Last Posted Date: 2021-12-10

Lead Sponsor: Imam Abdulrahman Bin Faisal University

Target Recruit Count: 80

Registration Number: NCT04312971

Locations: 🇸🇦
Imam Abdulrahamn Bin Faisal University (Former, Dammam University), Dammam, Esatern, Saudi Arabia
🇸🇦
Dammam University, Khobar, Eastern, Saudi Arabia

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