Norepinephrine

Generic Name
Norepinephrine
Brand Names
Levophed
Drug Type
Small Molecule
Chemical Formula
C8H11NO3
CAS Number
51-41-2
Unique Ingredient Identifier
X4W3ENH1CV
Background

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication

Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions
Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
Associated Therapies
-
Clinical Trials
Related News

Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia

First Posted Date
2019-02-21
Last Posted Date
2021-05-27
Lead Sponsor
Centre Hospitalier Régional d'Orléans
Target Recruit Count
124
Registration Number
NCT03849508
Locations
🇫🇷

Regional Hospital Center of ORLEANS, Orléans, France

The Phenylephrine vs. Norepinephrine Infusion Undergoing Cesarean Section

First Posted Date
2019-02-07
Last Posted Date
2020-02-10
Lead Sponsor
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Target Recruit Count
238
Registration Number
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Locations
🇨🇳

Xuanwu Hospital, Beijing, Beijing, China

Effect of a Higher Blood-pressure on Right Ventricular Function

First Posted Date
2019-01-16
Last Posted Date
2020-05-27
Lead Sponsor
Medical Centre Leeuwarden
Target Recruit Count
78
Registration Number
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Locations
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Medical Center Leeuwarden, Leeuwarden, Netherlands

Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section

First Posted Date
2018-10-25
Last Posted Date
2018-12-03
Lead Sponsor
Mongi Slim Hospital
Target Recruit Count
200
Registration Number
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Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery

First Posted Date
2018-03-30
Last Posted Date
2023-10-05
Lead Sponsor
University of Sao Paulo
Registration Number
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Norepinephrine vs Norepinephrine and Dobutamine in Cardiogenic Shock

Phase 3
Conditions
Cardiogenic Shock
Interventions
Drug: Norepinephrine
First Posted Date
2017-11-14
Last Posted Date
2017-11-14
Lead Sponsor
Central Hospital, Nancy, France
Target Recruit Count
40
Registration Number
NCT03340779
Locations
🇫🇷

CHU Nancy-Brabois, Vandoeuvre les nancy, France

Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean Delivery

First Posted Date
2017-11-01
Last Posted Date
2018-07-17
Lead Sponsor
Cairo University
Target Recruit Count
123
Registration Number
NCT03328533
Locations
🇪🇬

Cairo University, Cairo, Egypt

Angiotensin II for Septic Shock Treatment

First Posted Date
2017-10-05
Last Posted Date
2019-01-16
Lead Sponsor
Cairo University
Target Recruit Count
20
Registration Number
NCT03302650
Locations
🇪🇬

Cairo University, Cairo, Egypt

Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

First Posted Date
2017-09-19
Last Posted Date
2019-05-15
Lead Sponsor
Szeged University
Target Recruit Count
30
Registration Number
NCT03288051
Locations
🇭🇺

Department of Anaesthesiology and Intensive Therapy, Szeged, Csongrád, Hungary

Vasopressor Infusion in Cesarean Delivery

First Posted Date
2017-08-14
Last Posted Date
2021-09-27
Lead Sponsor
Cairo University
Target Recruit Count
120
Registration Number
NCT03248791
Locations
🇪🇬

Cairo University, Cairo, Egypt

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