Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a symp...
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
Phenylephrine in Septic Shock
- First Posted Date
- 2008-03-19
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 32
- Registration Number
- NCT00639015
- Locations
- 🇮🇹
Departement of Anesthesiology and Intensive Care of the University of Rome "La Sapienza" Viale del Policlinico 155, Rome, Italy
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
- First Posted Date
- 2008-01-29
- Last Posted Date
- 2023-01-11
- Lead Sponsor
- Rush University Medical Center
- Target Recruit Count
- 252
- Registration Number
- NCT00604019
- Locations
- 🇺🇸
RUSH University Medical Center, Chicago, Illinois, United States
Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis
- Conditions
- First Posted Date
- 2007-06-08
- Last Posted Date
- 2008-01-22
- Lead Sponsor
- Onze Lieve Vrouwe Gasthuis
- Target Recruit Count
- 80
- Registration Number
- NCT00484133
- Locations
- 🇳🇱
Onze Lieve Vrouwe Gasthuis, intensive care, Amsterdam, Netherlands
Continuous Infusion of Terlipressin in Septic Shock
- Conditions
- Interventions
- First Posted Date
- 2007-06-01
- Last Posted Date
- 2008-02-29
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 45
- Registration Number
- NCT00481572
- Locations
- 🇮🇹
Department of Anesthesiology and Intensive care of the University of Rome "La Sapienza", Rome, Viale del Policlinico 155, Italy
Drug Development Updates
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