Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Associated Therapies: -

Clinical Trials

The Effect of Terlipressin on Intesitnal Function in Septic Shock Patients

Not Applicable

Conditions: Terlipressin
Septic Shock

Interventions: Drug: Terlipressin
Drug: Norepinephrine

First Posted Date: 2014-12-03

Last Posted Date: 2014-12-30

Lead Sponsor: Liu ZiMeng

Target Recruit Count: 40

Registration Number: NCT02306239

Locations: 🇨🇳
the First Affiliated Hospital of Sumyetsan University, Guangzhou, Guangdong, China

The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements

Phase 4

Completed

Conditions: Head and Neck Cancer

Interventions: Drug: Norepinephrine
Other: no medication
Drug: Dopamine

First Posted Date: 2014-09-16

Last Posted Date: 2014-09-16

Lead Sponsor: Tampere University Hospital

Target Recruit Count: 25

Registration Number: NCT02241083

Locations: 🇫🇮
Tampere University Hospital, Tampere, P.O. Box 2000, Finland

Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients

Phase 4

Terminated

Conditions: Tachycardia
Septic Shock
Arrhythmia
Sepsis
Shock

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2014-07-30

Last Posted Date: 2018-06-13

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 17

Registration Number: NCT02203630

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Vascular Function and Uterine Fibroids

Completed

Conditions: Leiomyoma

Interventions: Device: Brachial artery catheter
Drug: Acetylcholine
Drug: Nitroprusside
Drug: Norepinephrine
Drug: Nitroprusside and phenylephrine

First Posted Date: 2014-04-25

Last Posted Date: 2018-03-02

Lead Sponsor: Mayo Clinic

Target Recruit Count: 28

Registration Number: NCT02123069

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Vasoactive Drugs in Intensive Care Unit

Phase 4

Recruiting

Conditions: Shock

Interventions: Drug: Norepinephrine
Drug: Phenylephrine
Drug: Epinephrine
Drug: Vasopressin

First Posted Date: 2014-04-21

Last Posted Date: 2024-12-09

Lead Sponsor: University of Chicago

Target Recruit Count: 836

Registration Number: NCT02118467

Locations: 🇺🇸
University of Chicago Medical Center, Chicago, Illinois, United States

Effect of Different Strategies for Titrating a High MAP on Microcirculation

Phase 4

Completed

Conditions: Hypertension
Septic Shock

Interventions: Drug: Crystalloid
Drug: Norepinephrine

First Posted Date: 2014-03-12

Last Posted Date: 2018-01-31

Lead Sponsor: Southeast University, China

Target Recruit Count: 24

Registration Number: NCT02085291

Locations: 🇨🇳
Nanjing Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China

Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury

Phase 2

Conditions: Severe Traumatic Brain Injury With High Cerebral Pressure

Interventions: Drug: Norepinephrine
Drug: Dobutamine and norepinephrine

First Posted Date: 2013-12-24

Last Posted Date: 2015-08-17

Lead Sponsor: University Hospital, Grenoble

Target Recruit Count: 20

Registration Number: NCT02019810

Locations: 🇫🇷
Grenoble University Hospital, Grenoble, France

Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit

Not Applicable

Completed

Conditions: Cirrhosis With Septic Shock

Interventions: Drug: Noradrenaline
Drug: Terlipressin

First Posted Date: 2013-04-19

Last Posted Date: 2016-11-22

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 84

Registration Number: NCT01836224

Locations: 🇮🇳
Institute of liver and Biliary Sciences, New Delhi, Delhi, India

Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients

Phase 3

Completed

Conditions: Septic Shock

Interventions: Drug: Norepinephrine
Drug: Vasopressin

First Posted Date: 2012-10-31

Last Posted Date: 2018-05-18

Lead Sponsor: Instituto do Cancer do Estado de São Paulo

Target Recruit Count: 250

Registration Number: NCT01718613

Locations: 🇧🇷
Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Sao Paulo/SP, Brazil

Continuos Terlipressin Infusion in Septic Shock

Not Applicable

Conditions: Septic Shock

Interventions: Drug: Norepinephrine
Drug: Terlipressin

First Posted Date: 2012-10-02

Last Posted Date: 2014-12-30

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 1000

Registration Number: NCT01697410

Locations: 🇨🇳
Surgical intensive care unit, 1st affiliated hospital of Sun Yat-sen university, Guangzhou, Guangdong, China

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2025. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy