Norepinephrine

Generic Name
Norepinephrine
Brand Names
Levophed
Drug Type
Small Molecule
Chemical Formula
C8H11NO3
CAS Number
51-41-2
Unique Ingredient Identifier
X4W3ENH1CV
Background

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a symp...

Indication

Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions
Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
Associated Therapies
-
Clinical Trials
Related News

Changes in Measured Plasma Volume, Glycocalyx and Atrial Natriuretic Peptide During Anaesthesia

First Posted Date
2016-07-14
Last Posted Date
2020-04-30
Lead Sponsor
Sahlgrenska University Hospital, Sweden
Target Recruit Count
24
Registration Number
NCT02832596
Locations
🇸🇪

Sahlgrenska University Hospital, Gothenburg, Sweden

Cardiac Output Changes in Cesarean Section

First Posted Date
2016-05-03
Last Posted Date
2016-05-03
Lead Sponsor
RenJi Hospital
Target Recruit Count
106
Registration Number
NCT02759510

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Effects of Vasopressors on Immune Response

First Posted Date
2016-02-05
Last Posted Date
2016-10-13
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
40
Registration Number
NCT02675868
Locations
🇳🇱

Radboudumc, Nijmegen, Gelderland, Netherlands

Norepinephrine To Prevent Hypotension After Spinal Anesthesia For Cesarean Delivery: A Dose Finding Study

Not Applicable
Completed
Conditions
Hypotension
Interventions
Drug: Norepinephrine
Drug: Normal Saline
First Posted Date
2016-01-13
Last Posted Date
2016-08-31
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
40
Registration Number
NCT02654847
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock

First Posted Date
2015-12-29
Last Posted Date
2018-11-29
Lead Sponsor
Sahlgrenska University Hospital, Sweden
Target Recruit Count
30
Registration Number
NCT02640846
Locations
🇸🇪

Central intensivvårdsavdelning Sahlgrenska University Hospital, Gothenburg, Västra Götaland, Sweden

Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients

First Posted Date
2015-09-07
Last Posted Date
2019-01-15
Lead Sponsor
Air Force Military Medical University, China
Target Recruit Count
66
Registration Number
NCT02542748
Locations
🇨🇳

Xijing Hospital,Fourth Military Medical University, Xi'an, Shaanxi, China

Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension

Phase 4
Completed
Conditions
Septic Shock
Interventions
Drug: norepinephrine
First Posted Date
2015-08-11
Last Posted Date
2017-04-04
Lead Sponsor
Federal University of São Paulo
Target Recruit Count
40
Registration Number
NCT02519699
Locations
🇧🇷

Hospital São Paulo - Universidade Federal de São Paulo, São Paulo, Brazil

Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.

Phase 3
Completed
Conditions
Vasoplegic Syndrome
Interventions
Drug: Norepinephrine
First Posted Date
2015-06-24
Last Posted Date
2016-10-21
Lead Sponsor
Centre Hospitalier Universitaire, Amiens
Target Recruit Count
130
Registration Number
NCT02479529
Locations
🇫🇷

CHU Amiens-Picardie, Amiens, Picardie, France

Ephedrine vs. Nor Epinephrine Infusion in Preventing Hypotension After Spinal Anesthesia for Cesarean Section

First Posted Date
2015-06-22
Last Posted Date
2017-10-26
Lead Sponsor
University Tunis El Manar
Target Recruit Count
120
Registration Number
NCT02477501
Locations
🇹🇳

Tunis maternity and neonatology center, minisetry of public health, Tunis, Tunisia

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