Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a symp...
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
Exploratory Study of Topical Norepinephrine in Breast Cancer Patients Receiving Radiotherapy
- First Posted Date
- 2012-03-06
- Last Posted Date
- 2012-05-28
- Lead Sponsor
- ProCertus BioPharm, Inc
- Registration Number
- NCT01544504
- Locations
- 🇺🇸
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Vascular Dysfunction in Diabetes: Genes and Hormones
- Conditions
- First Posted Date
- 2012-01-18
- Last Posted Date
- 2022-11-09
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT01511042
- Locations
- 🇺🇸
Brigham and Women's Hospital- 221 Longwood Avenue, Boston, Massachusetts, United States
Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery
- First Posted Date
- 2012-01-06
- Last Posted Date
- 2013-02-12
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 300
- Registration Number
- NCT01505231
- Locations
- 🇧🇷
Instituto do Coração, São Paulo, Brazil
Discontinuation Order of Vasopressors in Septic Shock
- First Posted Date
- 2011-12-15
- Last Posted Date
- 2015-01-30
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 78
- Registration Number
- NCT01493102
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
Genetic Mechanisms in Human Hypertension
- Conditions
- First Posted Date
- 2011-10-20
- Last Posted Date
- 2021-05-12
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT01456208
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Caveolin-1 and Vascular Dysfunction
- Conditions
- Interventions
- First Posted Date
- 2011-08-31
- Last Posted Date
- 2022-03-14
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT01426529
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
- Conditions
- Interventions
- First Posted Date
- 2011-08-16
- Last Posted Date
- 2011-08-16
- Lead Sponsor
- Oxford University Hospitals NHS Trust
- Target Recruit Count
- 25
- Registration Number
- NCT01418118
- Locations
- 🇬🇧
John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
Exploratory Study of Norepinephrine to Prevent Alopecia in Head and Neck Cancer Patients Treated With Radiotherapy
- First Posted Date
- 2011-06-07
- Last Posted Date
- 2012-03-23
- Lead Sponsor
- ProCertus BioPharm, Inc
- Target Recruit Count
- 3
- Registration Number
- NCT01367990
- Locations
- 🇺🇸
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
Exploratory Study of Norepinephrine to Prevent Radiodermatitis in Breast Cancer Patients
- First Posted Date
- 2010-12-20
- Last Posted Date
- 2013-04-19
- Lead Sponsor
- ProCertus BioPharm, Inc
- Target Recruit Count
- 10
- Registration Number
- NCT01263366
- Locations
- 🇺🇸
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation
- First Posted Date
- 2009-05-07
- Last Posted Date
- 2009-05-07
- Lead Sponsor
- Unidade de Terapia Intensiva
- Target Recruit Count
- 40
- Registration Number
- NCT00894621
- Locations
- 🇧🇷
Hospital Geral, Caxias do Sul, Rio Grande do Sul, Brazil
Drug Development Updates
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