Lithium carbonate
- Generic Name
- Lithium carbonate
- Brand Names
- Carbolith, Lithane, Lithmax, Lithobid
- Drug Type
- Small Molecule
- Chemical Formula
- CLi2O3
- CAS Number
- 554-13-2
- Unique Ingredient Identifier
- 2BMD2GNA4V
- Background
Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects.
- Indication
Lithium carbonate is indicated as a monotherapy for the treatment of acute manic and mixed episodes associated with bipolar 1 disorder in patients ≥7 years of age. It is also indicated as a maintenance treatment for bipolar 1 disorder in patients ≥7 years of age.
- Associated Conditions
- Bipolar 1 Disorder, Mixed manic depressive episode, Acute Manic episode
- Associated Therapies
- -
Study to Evaluate the Efficacy of Lithium Carbonate in Spinal Cord Injury Patients With Neuropathic Pain
- Conditions
- Interventions
- First Posted Date
- 2013-05-16
- Last Posted Date
- 2016-01-28
- Lead Sponsor
- China Spinal Cord Injury Network
- Target Recruit Count
- 60
- Registration Number
- NCT01855594
- Locations
- 🇨🇳
China Rehabilitation Research Center, Beijing, China
🇨🇳Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, Shanxi, China
Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
- Conditions
- Adult Acute Monoblastic Leukemia (M5a)Adult Acute Monocytic Leukemia (M5b)Adult Acute Myeloblastic Leukemia Without Maturation (M1)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myelomonocytic Leukemia (M4)Adult Acute Myeloblastic Leukemia With Maturation (M2)Adult Acute Myeloid Leukemia With Del(5q)Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Megakaryoblastic Leukemia (M7)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
- Interventions
- First Posted Date
- 2013-03-29
- Last Posted Date
- 2017-04-27
- Lead Sponsor
- Paolo Caimi, MD
- Target Recruit Count
- 12
- Registration Number
- NCT01820624
- Locations
- 🇺🇸
University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2012-12-21
- Last Posted Date
- 2016-01-07
- Lead Sponsor
- VA Eastern Colorado Health Care System
- Registration Number
- NCT01754883
- Locations
- 🇺🇸
Denver Veterans Hospital, Denver, Colorado, United States
Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma
- First Posted Date
- 2012-08-21
- Last Posted Date
- 2016-11-01
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 400
- Registration Number
- NCT01669369
- Locations
- 🇨🇳
The first affiliated hospital,Sun Yat-sen University, Guangzhou, Guangdong, China
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects
- First Posted Date
- 2012-03-29
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- Nova Scotia Health Authority
- Target Recruit Count
- 2
- Registration Number
- NCT01565759
- Locations
- 🇨🇦
Department of Psychiatry, Abbie J Lane Building, Halifax, Nova Scotia, Canada
Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain
- Conditions
- Interventions
- First Posted Date
- 2012-03-14
- Last Posted Date
- 2018-07-05
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 19
- Registration Number
- NCT01553916
- Locations
- 🇺🇸
Washinton University School of Medicine, Saint Louis, Missouri, United States
A Pilot Study of Lithium in Progressive Multiple Sclerosis
- First Posted Date
- 2010-12-14
- Last Posted Date
- 2019-09-10
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 23
- Registration Number
- NCT01259388
- Locations
- 🇺🇸
Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama, United States
🇺🇸Kirklin Clinic, Birmingham, Alabama, United States
Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms
- Conditions
- Interventions
- First Posted Date
- 2010-08-27
- Last Posted Date
- 2011-08-24
- Lead Sponsor
- Columbia Northwest Pharmaceuticals
- Target Recruit Count
- 80
- Registration Number
- NCT01189812
- Locations
- 🇺🇸
Artemis Institute for Clinical Research, San Diego, California, United States
🇺🇸Northwest Clinical Research Center, Bellevue, Washington, United States
Safety and Efficacy Study of Lithium for the Treatment of Pediatric Mania.
- First Posted Date
- 2010-07-21
- Last Posted Date
- 2013-10-09
- Target Recruit Count
- 81
- Registration Number
- NCT01166425
- Locations
- 🇺🇸
University of Kansas School of Medicine, Psychiatry and Behavioral Sciences, 1010 N Kansas St, Wichita, Kansas, United States
🇺🇸Childrens National Medical Center, Washington, District of Columbia, United States
🇺🇸University Hospitals Case Medical Center, Cleveland, Ohio, United States
The Neurotrophic Effects of Lithium Carbonate Following Stroke: A Feasibility Study
- First Posted Date
- 2010-04-28
- Last Posted Date
- 2024-01-31
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 12
- Registration Number
- NCT01112813
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Drug Development Updates
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