Leucovorin

Generic Name
Leucovorin
Brand Names
EnBrace HR, EnLyte, Lederle Leucovorin
Drug Type
Small Molecule
Chemical Formula
C20H23N7O7
CAS Number
58-05-9
Unique Ingredient Identifier
Q573I9DVLP
Background

Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro...

Indication

For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in t...

Associated Conditions
Advanced Colorectal Cancer, Advanced Esophageal Cancers, Anemia of Pregnancy, Bladder Cancer, Folate and iron deficiency, Folate deficiency, Folic acid antagonist overdose, Iron Deficiency (ID), Macrocytic anemia, Megaloblastic anemia, Pancreatic Metastatic Cancer, Postpartum Anemia, Stage IV Gastric Cancer, Hypochromic anemia, Methotrexate toxicity, Normochromic anemia, Pyrimethamine hematologic toxicity
Associated Therapies
-
Clinical Trials
Related News

Trial Comparing Two Strategies of Chemotherapy for Metastatic Colorectal Cancer

Phase 3
Completed
Conditions
Metastasis
Colorectal Cancer
First Posted Date
2005-08-03
Last Posted Date
2015-08-13
Lead Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
Target Recruit Count
570
Registration Number
NCT00126256
Locations
🇫🇷

Institut Gustave-Roussy, Villejuif, France

Evaluating Panitumumab (ABX-EGF) in Patients With Metastatic Colorectal Cancer

First Posted Date
2005-05-26
Last Posted Date
2013-12-12
Lead Sponsor
Amgen
Target Recruit Count
43
Registration Number
NCT00111761

S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

First Posted Date
2005-05-04
Last Posted Date
2015-03-25
Lead Sponsor
SWOG Cancer Research Network
Target Recruit Count
79
Registration Number
NCT00109837
Locations
🇺🇸

Providence Saint Joseph Medical Center - Burbank, Burbank, California, United States

🇺🇸

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States

🇺🇸

Minor and James Medical, PLLC, Seattle, Washington, United States

and more 75 locations

Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant

First Posted Date
2004-05-19
Last Posted Date
2024-05-17
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
46
Registration Number
NCT00082706
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer

First Posted Date
2004-04-08
Last Posted Date
2020-02-27
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
146
Registration Number
NCT00081289
Locations
🇺🇸

Baptist-South Miami Regional Cancer Program, Miami, Florida, United States

🇺🇸

University of California Davis Cancer Center, Sacramento, California, United States

🇺🇸

Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois, United States

and more 2 locations

A Study of Xeloda (Capecitabine) Compared With 5-Fluorouracil in Combination With Low-Dose Leucovorin in Patients Who Have Undergone Surgery for Colon Cancer

First Posted Date
2004-03-17
Last Posted Date
2016-06-22
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
1987
Registration Number
NCT00009737

FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum

First Posted Date
2004-02-11
Last Posted Date
2018-05-16
Lead Sponsor
Alliance for Clinical Trials in Oncology
Target Recruit Count
238
Registration Number
NCT00077233
Locations
🇺🇸

Memorial Regional Cancer Center at Memorial Regional Hospital, Hollywood, Florida, United States

🇺🇸

MBCCOP - University of Illinois at Chicago, Chicago, Illinois, United States

🇺🇸

CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States

and more 74 locations

A Study of Xeloda (Capecitabine) in Patients With Metastatic Colorectal Cancer

First Posted Date
2003-09-18
Last Posted Date
2016-04-01
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
627
Registration Number
NCT00069108

Safety, Tolerability and Efficacy of ZD6126 in Combination With Oxaliplatin, 5-Fluorouracil and Leucovorin in Subjects With Metastatic Colorectal Cancer.

Phase 2
Terminated
Conditions
Colorectal Neoplasms
Metastases, Neoplasm
First Posted Date
2003-07-18
Last Posted Date
2011-01-26
Lead Sponsor
AstraZeneca
Target Recruit Count
180
Registration Number
NCT00065117
Locations
🇺🇸

Research Site, Pittsburgh, Pennsylvania, United States

Study of Cetuximab, Oxaliplatin, 5-FU/LV Versus Oxaliplatin, 5-FU/LV in Patients With Previously Treated Metastatic, EGFR-Positive Colorectal Cancer

First Posted Date
2003-06-06
Last Posted Date
2010-04-12
Lead Sponsor
Eli Lilly and Company
Target Recruit Count
102
Registration Number
NCT00061815
Locations
🇺🇸

ImClone Investigational Site, Richmond, Virginia, United States

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