Magnesium sulfate
- Generic Name
- Magnesium sulfate
- Brand Names
- Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
- Drug Type
- Small Molecule
- Chemical Formula
- MgO4S
- CAS Number
- 7487-88-9
- Unique Ingredient Identifier
- ML30MJ2U7I
- Background
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
- Indication
Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
- Associated Conditions
- Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
- Associated Therapies
- Bowel preparation therapy, Soaking aid for minor sprains and bruises
Efficacy of Intraoperative Magnesium Sulphate vs Dexmedetomidine on Emergence Agitation in Pediatric Patients
- Conditions
- Magnesium SulphateDexmedetomidineEmergence AgitationPediatric Patients
- Interventions
- First Posted Date
- 2025-05-18
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT06977425
- Locations
- 🇪🇬
Ain shams university, Cairo, Egypt
Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia
- Conditions
- Cough
- Interventions
- First Posted Date
- 2025-05-18
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- Al-Azhar University
- Target Recruit Count
- 300
- Registration Number
- NCT06979141
Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke
- First Posted Date
- 2025-05-04
- Last Posted Date
- 2025-05-14
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 30
- Registration Number
- NCT06956521
Magnesium Sulfate in Bronchial Asthma and Acute Bronchiolitis in Children
- First Posted Date
- 2025-05-02
- Last Posted Date
- 2025-05-02
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT06955559
Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery
- Conditions
- Chronic RhinosinusitisEnhanced Recovery After Surgery
- Interventions
- First Posted Date
- 2025-04-10
- Last Posted Date
- 2025-04-10
- Lead Sponsor
- The Second People's Hospital of Huai'an
- Target Recruit Count
- 144
- Registration Number
- NCT06920576
- Locations
- 🇨🇳
The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second Hospital, Huaian, China
Magnesium and Cramping
- Conditions
- Uterine CrampsPostoperative Pain ManagementHysteroscopy
- Interventions
- First Posted Date
- 2025-03-25
- Last Posted Date
- 2025-04-03
- Lead Sponsor
- William Beaumont Hospitals
- Target Recruit Count
- 150
- Registration Number
- NCT06745388
- Locations
- 🇺🇸
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, United States
Dexmedetomidine Versus Magnesium Sulfate as Adjuvants to Intraperitoneal Bupivacaine for Postoperative Analgesia After Elective Laparoscopic Cholecystectomy
- Conditions
- DexmedetomidineMagnesium SulfateAdjuvantsIntraperitoneal BupivacainePostoperative AnalgesiaElective Laparoscopic Cholecystectomy
- Interventions
- First Posted Date
- 2025-03-17
- Last Posted Date
- 2025-03-17
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 75
- Registration Number
- NCT06879288
- Locations
- 🇪🇬
Tanta University, Tanta, El-Gharbia, Egypt
Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen Saturation
- Conditions
- Cerebral Desaturation EventsSpine Surgeries
- Interventions
- First Posted Date
- 2025-02-27
- Last Posted Date
- 2025-02-27
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 90
- Registration Number
- NCT06848595
Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) Therapy, a Phase 2 Randomized Study
- Conditions
- Acute Myeloid Leukemia (AML)
- Interventions
- First Posted Date
- 2025-02-06
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 140
- Registration Number
- NCT06811233
- Locations
- 🇺🇸
The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States
Magnesium Trial in Acute Asthma in Emergency Department
- First Posted Date
- 2025-01-21
- Last Posted Date
- 2025-01-21
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 192
- Registration Number
- NCT06785272
- Locations
- 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇨🇦Stollery Children's Hospital, Edmonton, Ontario, Canada
🇨🇦McMaster Children's Hospital, Hamilton, Ontario, Canada
Drug Development Updates
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