Buprenorphine
- Generic Name
- Buprenorphine
- Brand Names
- Belbuca, Brixadi, Buprenex, Buprenorphine, Butrans, Sublocade, Suboxone, Subutex, Zubsolv, Buvidal, Sixmo
- Drug Type
- Small Molecule
- Chemical Formula
- C29H41NO4
- CAS Number
- 52485-79-7
- Unique Ingredient Identifier
- 40D3SCR4GZ
- Background
Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain. It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is formulated in a 4:1 fixed-dose c...
- Indication
Buprenorphine is available in different formulations, such as sublingual tablets, buccal films, transdermal films, and injections, alone or in combination with naloxone.
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- Associated Conditions
- Opioid Dependence, Severe Pain, Moderate Opioid Dependence, Moderate Pain, Severe Opioid Dependence
- Associated Therapies
- -
Pharmacokinetic Interactions Between Buprenorphine and Kaletra (Lopinavir/Ritonavir)
- Conditions
- Interventions
- First Posted Date
- 2007-12-12
- Last Posted Date
- 2012-11-21
- Lead Sponsor
- Yale University
- Target Recruit Count
- 12
- Registration Number
- NCT00571961
- Locations
- 🇺🇸
Yale University School of Medicine, New Haven, Connecticut, United States
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
- Conditions
- Interventions
- First Posted Date
- 2007-09-18
- Last Posted Date
- 2012-09-10
- Lead Sponsor
- Purdue Pharma LP
- Target Recruit Count
- 567
- Registration Number
- NCT00531427
- Locations
- 🇺🇸
Stat-Lab I, Inc., Baton Rouge, Louisiana, United States
🇺🇸Arthritis Clinic, PLLC, Jackson, Tennessee, United States
🇺🇸Coastal Pain Management, Bradenton, Florida, United States
Buprenorphine for the Treatment of Neonatal Abstinence Syndrome
- Conditions
- Interventions
- First Posted Date
- 2007-08-27
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 60
- Registration Number
- NCT00521248
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Study of Buprenorphine Maintenance Treatment for Opioid Dependence in Primary Care
- Conditions
- First Posted Date
- 2007-05-09
- Last Posted Date
- 2019-04-23
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 30
- Registration Number
- NCT00471042
- Locations
- 🇺🇸
Columbia University/New York State Psychiatric Institute, New York, New York, United States
Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID: 855509)
- Conditions
- First Posted Date
- 2007-05-04
- Last Posted Date
- 2007-11-16
- Lead Sponsor
- Grünenthal GmbH
- Target Recruit Count
- 36
- Registration Number
- NCT00469053
- Locations
- 🇩🇪
Site Mannheim, Mannheim, Germany
Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations (Protocol ID 297307)
- Conditions
- First Posted Date
- 2007-05-04
- Last Posted Date
- 2007-11-16
- Lead Sponsor
- Grünenthal GmbH
- Target Recruit Count
- 24
- Registration Number
- NCT00469404
- Locations
- 🇩🇪
Site Mannheim, Mannheim, Germany
Buprenorphine's Dose Response Curve
- Conditions
- Interventions
- First Posted Date
- 2007-04-13
- Last Posted Date
- 2017-03-03
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 12
- Registration Number
- NCT00460239
- Locations
- 🇺🇸
Johns Hopkins University (BPRU) Bayview Campus, Baltimore, Maryland, United States
Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip Knee and/or Lumbar Spine
- First Posted Date
- 2007-01-25
- Last Posted Date
- 2010-02-01
- Lead Sponsor
- Norpharma A/S
- Target Recruit Count
- 120
- Registration Number
- NCT00426647
- Locations
- 🇫🇮
Dr. Olavi Airaksinen, Oma Lääkäri Oy, Vuorikatu 20, Kuopio, Finland
Treatment of Polydrug-Using Opiate Dependents During Withdrawal
- Conditions
- First Posted Date
- 2006-08-23
- Last Posted Date
- 2006-08-23
- Lead Sponsor
- Sorlandet Hospital HF
- Target Recruit Count
- 12
- Registration Number
- NCT00367874
- Locations
- 🇳🇴
Sorlandet Hospital HF, Addiction Unit (ARA), Kristiansand, Vest-Agder, Norway
Buprenorphine Maintenance for Opioid-Addicted Persons in Jail and Post-Release
- First Posted Date
- 2006-08-22
- Last Posted Date
- 2013-05-01
- Target Recruit Count
- 116
- Registration Number
- NCT00367302
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.