Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
- Conditions
- Interventions
- First Posted Date
- 2020-08-05
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 240
- Registration Number
- NCT04500002
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Isonicotinic Acid Hydrazide Pretreatment With Misoprostol Induction of Abortion in First-trimester Missed Miscarriage
- First Posted Date
- 2020-08-05
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 240
- Registration Number
- NCT04499976
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Early Versus Delayed Artificial Rupture of Membranes (AROM Trial)
- Conditions
- Interventions
- First Posted Date
- 2020-08-04
- Last Posted Date
- 2021-12-03
- Lead Sponsor
- Christiana Care Health Services
- Target Recruit Count
- 160
- Registration Number
- NCT04496908
- Locations
- 🇺🇸
Christiana Care Health Systems, Newark, Delaware, United States
Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
- Conditions
- Interventions
- First Posted Date
- 2020-07-30
- Last Posted Date
- 2022-06-14
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 150
- Registration Number
- NCT04492072
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Isosorbide Mononitrate in Induction of Labour
- Conditions
- Interventions
- First Posted Date
- 2020-07-23
- Last Posted Date
- 2020-07-23
- Lead Sponsor
- Aljazeera Hospital
- Target Recruit Count
- 130
- Registration Number
- NCT04482881
- Locations
- 🇪🇬
Algazeerah, Giza, Egypt
Efficacy and Safety of Different Doses of Vaginal Misoprostol Prior to Intra Uterine Contraceptive Device Insertion
- First Posted Date
- 2020-02-18
- Last Posted Date
- 2020-07-14
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 180
- Registration Number
- NCT04273984
- Locations
- 🇪🇬
Misr University for Science & Technology, Cairo, Egypt
🇪🇬Ain Shams University Maternity Hospital, Cairo, Egypt
Misoprostol as a Treatment for Endometrial Polyps in Infertile Patients
- First Posted Date
- 2020-02-17
- Last Posted Date
- 2020-02-17
- Lead Sponsor
- Henry Aristoteles Mate-Sánez
- Target Recruit Count
- 54
- Registration Number
- NCT04270994
Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of Membranes
- Conditions
- Interventions
- First Posted Date
- 2019-10-29
- Last Posted Date
- 2020-01-29
- Lead Sponsor
- sammour.rami
- Target Recruit Count
- 200
- Registration Number
- NCT04143685
- Locations
- 🇮🇱
Bnai Zion Medical Center, Haifa, Israel
Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases
- Conditions
- Interventions
- First Posted Date
- 2019-10-07
- Last Posted Date
- 2020-01-31
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 345
- Registration Number
- NCT04117243
- Locations
- 🇪🇬
Faculty of Medicine, Cairo, Egypt
Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Nulliparous Women
- Conditions
- Interventions
- First Posted Date
- 2019-09-06
- Last Posted Date
- 2020-06-30
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 129
- Registration Number
- NCT04080336
- Locations
- 🇪🇬
Ahmed Samy, Giza, Egypt
Drug Development Updates
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