Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage
- Conditions
- Postpartum Hemorrhage
- Interventions
- First Posted Date
- 2022-02-17
- Last Posted Date
- 2025-05-04
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 1358
- Registration Number
- NCT05245227
- Locations
- 🇺🇸
Stony Brook University, Stony Brook, New York, United States
Ulipristal Acetate for Use in Early Pregnancy Loss
- Conditions
- Non-Viable PregnancyMissed AbortionAnembryonic Pregnancy
- Interventions
- First Posted Date
- 2022-02-01
- Last Posted Date
- 2023-06-28
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 3
- Registration Number
- NCT05216952
- Locations
- 🇺🇸
University of North Carolina, Chapel Hill - Weaver Crossing, Chapel Hill, North Carolina, United States
🇺🇸University of North Carolina, Chapel Hill - Same Day OBGYN Clinic, Chapel Hill, North Carolina, United States
🇺🇸University of North Carolina, Chapel Hill - Hillsborough Medical Office Building, Hillsborough, North Carolina, United States
Induction of Labor in Pregnant Women With Prelabor Rupture of Membranes - Oxytocin or Misoprostol
- Conditions
- Prelabor Rupture of Membranes
- Interventions
- First Posted Date
- 2022-01-31
- Last Posted Date
- 2022-06-23
- Lead Sponsor
- Ain Shams Maternity Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT05215873
- Locations
- 🇪🇬
Ain Shams Maternity Hospital, Cairo, Egypt
Letrozole in Induction of Abortion of Anembryonic Pregnancy
- Conditions
- Anembryonic Pregnancy
- Interventions
- First Posted Date
- 2022-01-20
- Last Posted Date
- 2023-09-11
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 96
- Registration Number
- NCT05198050
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Mid Trimester Abortion Effectiveness by Dilapan s
- First Posted Date
- 2021-12-07
- Last Posted Date
- 2021-12-07
- Lead Sponsor
- Ain Shams Maternity Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT05147857
- Locations
- 🇪🇬
Ainshams Maternity Hospital, Cairo, Egypt
Comparison of Two Different Drug Regimens for Medical Treatment of Early Pregnancy Loss
- Conditions
- Abortion, Missed
- Interventions
- Drug: Mifepristone, Oral, 200 Mg
- First Posted Date
- 2021-11-17
- Last Posted Date
- 2021-11-17
- Lead Sponsor
- Clinical Hospital Merkur
- Target Recruit Count
- 220
- Registration Number
- NCT05124314
- Locations
- 🇭🇷
Clinical Hospital Merkur, Zagreb, Grad Zagreb, Croatia
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy
- First Posted Date
- 2021-11-05
- Last Posted Date
- 2021-11-05
- Lead Sponsor
- Pak Emirates Military Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT05108597
- Locations
- 🇵🇰
PEMH, Rawalpindi, Punjab, Pakistan
Sublingual Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
- First Posted Date
- 2021-11-02
- Last Posted Date
- 2021-11-02
- Lead Sponsor
- hany farouk
- Target Recruit Count
- 200
- Registration Number
- NCT05103098
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Mifepristone for Labor Induction
- First Posted Date
- 2021-10-28
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 30
- Registration Number
- NCT05097326
- Locations
- 🇺🇸
Lucile Packard Children's Hospital, Palo Alto, California, United States
Vaginal Misoprostol In Medical Treatment of First Trimester Missed Miscarriage
- Conditions
- Miscarriage
- Interventions
- First Posted Date
- 2021-10-26
- Last Posted Date
- 2021-10-26
- Lead Sponsor
- hany farouk
- Target Recruit Count
- 200
- Registration Number
- NCT05094375
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Drug Development Updates
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