Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section
- Conditions
- Transient Tachypnea of the NewbornNeonatal Respiratory Distress
- Interventions
- Drug: Placebo
- First Posted Date
- 2021-03-03
- Last Posted Date
- 2021-03-03
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 210
- Registration Number
- NCT04780412
- Locations
- 🇪🇬
Ain Shams University - Faculty of Medicine, Cairo, Egypt
Misoprostol for Bloating and Distension
- Conditions
- DistensionGas Bloat SyndromeConstipation
- Interventions
- First Posted Date
- 2021-02-24
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- Montefiore Medical Center
- Registration Number
- NCT04768010
Uterotonics for Severe Preeclampsia
- Conditions
- Preeclampsia Severe
- Interventions
- First Posted Date
- 2021-02-16
- Last Posted Date
- 2021-02-16
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 124
- Registration Number
- NCT04756661
- Locations
- 🇪🇬
Assiut Faculty of Medicine, Assiut, Egypt
Prevention of Primary Postpartum Haemorrhage
- First Posted Date
- 2021-01-26
- Last Posted Date
- 2021-02-25
- Lead Sponsor
- Islamabad Medical and Dental College
- Target Recruit Count
- 180
- Registration Number
- NCT04724187
- Locations
- 🇵🇰
Islamabad medical and Dental College, Islamabad, Federal, Pakistan
Safety of Tranexamic Acid in Reducing Blood Loss Myomectomy.
- Conditions
- Myoma
- Interventions
- Drug: women receiving tranexamic acid
- First Posted Date
- 2021-01-05
- Last Posted Date
- 2021-01-05
- Lead Sponsor
- Aljazeera Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT04694677
- Locations
- 🇪🇬
Algazeerah, Giza, Egypt
Management of RPOC After Induced Abortion
- First Posted Date
- 2020-12-28
- Last Posted Date
- 2022-05-03
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 141
- Registration Number
- NCT04685694
- Locations
- 🇮🇱
Tel Aviv Medical Center; ,, Tel Aviv, Israel
Prostaglandins Use Before Mirena IUD Insertion in Prev CS Women During Lactational Amenorrhea
- Conditions
- to Study the Estimate Difficulty of Insertion Mirena IUD With Use of Prostaglandins
- Interventions
- First Posted Date
- 2020-11-27
- Last Posted Date
- 2021-01-19
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 400
- Registration Number
- NCT04646161
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida
- Conditions
- MisoprostolCesarean Section ComplicationsBlood Loss, SurgicalTranexamic Acid
- Interventions
- First Posted Date
- 2020-11-18
- Last Posted Date
- 2022-07-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 200
- Registration Number
- NCT04635007
- Locations
- 🇪🇬
faculty of medicine - Cairo university, Cairo, Kasr El Ainy, Egypt
Misoprostol for Spinal Stenosis
- First Posted Date
- 2020-11-02
- Last Posted Date
- 2020-11-02
- Lead Sponsor
- Dallas VA Medical Center
- Target Recruit Count
- 23
- Registration Number
- NCT04611464
- Locations
- 🇺🇸
Dallas VA Medical Center, Dallas, Texas, United States
Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First Trimester Missed Miscarriage
- First Posted Date
- 2020-10-27
- Last Posted Date
- 2022-05-24
- Lead Sponsor
- Islamabad Medical and Dental College
- Target Recruit Count
- 120
- Registration Number
- NCT04604366
- Locations
- 🇵🇰
Islamabad Medical and Dental College, Islamabad, Federal, Pakistan
Drug Development Updates
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