Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Tranexamic Acid Plus Buccal Misoprostol on Blood Loss During and After Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2018-10-18
- Last Posted Date
- 2020-07-14
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT03710304
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Carbetocin Versus Buccal Misoprostol Plus IV Tranexamic Acid for Prevention of Postpartum Hemorrhage at Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2018-10-18
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT03710317
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery
- Conditions
- Interventions
- First Posted Date
- 2018-10-17
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 360
- Registration Number
- NCT03708497
- Locations
- 🇪🇬
AswanUH, Aswan, Egypt
🇪🇬Aswan University, Aswan, Egypt
Vaginal Misoprostol With Intracervical Foley Catheter in Induction of Labor
- Conditions
- Interventions
- First Posted Date
- 2018-09-25
- Last Posted Date
- 2021-01-20
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 120
- Registration Number
- NCT03682718
- Locations
- 🇪🇬
Ahmed Abass, Cairo, Egypt
The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS
- Conditions
- Interventions
- First Posted Date
- 2018-09-21
- Last Posted Date
- 2023-06-27
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 200
- Registration Number
- NCT03680339
- Locations
- 🇪🇬
Kasr Alainy medical school, Cairo, Egypt
Buccal Misoprostol Versus IV Oxytocin in Prevention of Postpartum Hemorrhage
- First Posted Date
- 2018-09-19
- Last Posted Date
- 2021-09-29
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 154
- Registration Number
- NCT03676621
- Locations
- 🇪🇬
Assiut Faculty of Medicine, Assiut, Egypt
Cervical Preparation in Hysteroscopy
- First Posted Date
- 2018-09-18
- Last Posted Date
- 2019-01-09
- Lead Sponsor
- Aljazeera Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT03675802
- Locations
- 🇪🇬
Algazeerah, Giza, Egypt
Comparison of Misoprostol Ripening Efficacy With Dilapan
- Conditions
- Interventions
- First Posted Date
- 2018-09-14
- Last Posted Date
- 2024-07-19
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 307
- Registration Number
- NCT03670836
- Locations
- 🇺🇸
New York Presbyterian - Allen Hospital, New York, New York, United States
🇺🇸University of Texas, Galveston, Texas, United States
Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
- Conditions
- Interventions
- First Posted Date
- 2018-08-14
- Last Posted Date
- 2018-10-09
- Lead Sponsor
- Ain Shams Maternity Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT03628625
- Locations
- 🇪🇬
Ain Shams University, Maternity Hospital, Cairo, Egypt
Misoprostol for Cervical Ripening Before Copper Intrauterine Device Removal
- First Posted Date
- 2018-07-26
- Last Posted Date
- 2020-09-16
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT03600064
- Locations
- 🇪🇬
Women Health Hospital - Assiut university, Assiut, Egypt
Drug Development Updates
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