Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Methods to Reduce Blood Loss in Abdominal Myomectomy
- Conditions
- Abdominal MyomectomyBlood Loss
- Interventions
- Procedure: pericervical hemostatic tourniquet
- First Posted Date
- 2020-10-22
- Last Posted Date
- 2020-10-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 120
- Registration Number
- NCT04595812
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
- Conditions
- To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
- Interventions
- First Posted Date
- 2020-09-23
- Last Posted Date
- 2021-09-13
- Lead Sponsor
- Rajavithi Hospital
- Target Recruit Count
- 135
- Registration Number
- NCT04560218
- Locations
- 🇹🇭
Rajavithi hospital, Bangkok, Thailand
Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas
- Conditions
- Induction of Labor Affected Fetus / Newborn
- Interventions
- First Posted Date
- 2020-09-01
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- Ahmed mohamed fathy ismail
- Target Recruit Count
- 128
- Registration Number
- NCT04533841
- Locations
- 🇪🇬
Ahmed mohamed fathy ismail, Zagazig, El Sharquia, Egypt
Impact of Early Versus Late Amniotomy on Labour Induction in Nulliparous Women After Vaginal Misoprostol
- First Posted Date
- 2020-08-17
- Last Posted Date
- 2020-08-17
- Lead Sponsor
- Menoufia University
- Target Recruit Count
- 140
- Registration Number
- NCT04514770
- Locations
- 🇪🇬
Menoufia University hospital, Shibīn Al Kawm, Menoufia, Egypt
Vaginal Misoprostol and Dinoprostone and Isonicotinic Acid Hydrazide Prior to Copper Intrauterine Device Insertion
- Conditions
- IUCD Complication
- Interventions
- First Posted Date
- 2020-08-10
- Last Posted Date
- 2020-08-18
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04505943
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women
- Conditions
- IUCD Complication
- Interventions
- First Posted Date
- 2020-08-10
- Last Posted Date
- 2020-08-18
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04505917
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
- Conditions
- IUCD Complication
- Interventions
- First Posted Date
- 2020-08-05
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 240
- Registration Number
- NCT04500002
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Isonicotinic Acid Hydrazide Pretreatment With Misoprostol Induction of Abortion in First-trimester Missed Miscarriage
- First Posted Date
- 2020-08-05
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 240
- Registration Number
- NCT04499976
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Early Versus Delayed Artificial Rupture of Membranes (AROM Trial)
- Conditions
- Induction of Labor Affected Fetus / Newborn
- Interventions
- First Posted Date
- 2020-08-04
- Last Posted Date
- 2021-12-03
- Lead Sponsor
- Christiana Care Health Services
- Target Recruit Count
- 160
- Registration Number
- NCT04496908
- Locations
- 🇺🇸
Christiana Care Health Systems, Newark, Delaware, United States
Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions
- Conditions
- Cesarean SectionOxytocinMisoprostolHigh Risk Pregnancy
- Interventions
- First Posted Date
- 2020-07-30
- Last Posted Date
- 2022-06-14
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 150
- Registration Number
- NCT04492072
- Locations
- 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Drug Development Updates
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