Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Misoprostol for Management of Women With an Incomplete Miscarriage
- First Posted Date
- 2021-10-22
- Last Posted Date
- 2021-10-22
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT05088720
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Sublingual Versus Vaginal Misoprostol In Medical Treatment of Second Trimestric Missed Miscarriage
- Conditions
- Miscarriage
- Interventions
- First Posted Date
- 2021-10-22
- Last Posted Date
- 2021-10-22
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT05088707
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
A Trial of Sublingual Misoprostol to Reduce Primary Postpartum Haemorrhage After Vaginal Delivery
- Conditions
- Primary Postpartum HemorrhageMisoprostolDelivery Complication
- Interventions
- First Posted Date
- 2021-10-15
- Last Posted Date
- 2022-03-03
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 1300
- Registration Number
- NCT05079061
Oxytocin Versus, Sublingual Misoprostol in the Secondary Prevention of Postpartum Hemorrhage After Vaginal Delivery
- First Posted Date
- 2021-10-14
- Last Posted Date
- 2021-10-22
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT05077540
Sublingual vs Vaginal Misoprostol for Termination of First Trimesteric Missed Abortion
- First Posted Date
- 2021-08-11
- Last Posted Date
- 2021-08-11
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 288
- Registration Number
- NCT05001061
Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion
- Conditions
- Induction of Second Trimester Abortion
- Interventions
- First Posted Date
- 2021-08-04
- Last Posted Date
- 2021-08-04
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 24
- Registration Number
- NCT04989400
- Locations
- 🇪🇬
Ain SHams Maternity Hospital, Cairo, Abbaseya, Egypt
Comparative Study Between Combined Vaginal Misoprostol
- First Posted Date
- 2021-07-29
- Last Posted Date
- 2021-07-29
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT04981457
- Locations
- 🇪🇬
Cairo U, Cairo, Married, Egypt
Missed Period Pill Study
- Conditions
- Menstrual RegulationMenstrual Irregularity
- Interventions
- First Posted Date
- 2021-06-25
- Last Posted Date
- 2024-10-03
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 100
- Registration Number
- NCT04940013
- Locations
- 🇺🇸
University of California, San Francisco, Fresno, California, United States
Misoprostol Prior to Intrauterine Device Insertion
- First Posted Date
- 2021-06-21
- Last Posted Date
- 2023-05-03
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT04932382
- Locations
- 🇪🇬
Women Health Hospital - Assiut university, Assiut, Egypt
To Study the Efficacy and Safety of Misoprostol by Sublingual Routes for Induction of Labour
- First Posted Date
- 2021-05-14
- Last Posted Date
- 2021-05-17
- Lead Sponsor
- Ministry of Health, Bhutan
- Target Recruit Count
- 500
- Registration Number
- NCT04887493
- Locations
- 🇧🇹
Phuentsholing Hospital, Phuentsholing, Bhutan
Drug Development Updates
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