Nicardipine

Generic Name: Nicardipine

Brand Names: Cardene

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₉N_₃O_₆

CAS Number: 55985-32-5

Unique Ingredient Identifier: CZ5312222S

Background: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]

Indication: Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Associated Conditions: Chronic Stable Angina Pectoris, Hypertension, Migraine, Blood pressure >185/110 mm Hg arterial hypertension

Associated Therapies: -

Clinical Trials

Effect of Nicardipine on Renal Function in Deliberate Hypotension

Phase 4

Completed

Conditions: Spinal Stenosis

Interventions: Drug: Nicardipine

First Posted Date: 2014-10-22

Last Posted Date: 2014-10-23

Lead Sponsor: Yonsei University

Target Recruit Count: 64

Registration Number: NCT02271191

The Intra-arterial Vasospasm Trial

Phase 4

Recruiting

Conditions: Cerebral Vasospasm

Interventions: Drug: Nicardipine + Verapamil + Nitroglycerin
Drug: Nicardipine
Drug: Verapamil

First Posted Date: 2013-11-27

Last Posted Date: 2024-07-12

Lead Sponsor: Peng Roc Chen, MD

Target Recruit Count: 330

Registration Number: NCT01996436

Locations: 🇺🇸
Northwell Health, Manhasset, New York, United States
🇺🇸
Geisinger Clinic, Danville, Pennsylvania, United States
🇺🇸
University of Illinois College of Medicine at Chicago, Chicago, Illinois, United States

and more 7 locations

Nicardipine vs Esmolol Craniotomy Emergence

Phase 1

Completed

Conditions: Brain Tumors

Interventions: Drug: Esmolol
Drug: Nicardipine

First Posted Date: 2013-09-27

Last Posted Date: 2014-08-29

Lead Sponsor: Northwestern University

Target Recruit Count: 40

Registration Number: NCT01951950

Locations: 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States

The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

Not Applicable

Completed

Conditions: Healthy Subjects

Interventions: Drug: Nicardipine
Drug: remifentanil

First Posted Date: 2010-08-05

Last Posted Date: 2013-06-13

Lead Sponsor: Yonsei University

Target Recruit Count: 46

Registration Number: NCT01175746

Nicardipine Versus Labetalol During Intubation

Not Applicable

Conditions: Patients Who Are Intubated for General Anesthesia
Endotracheal Intubation

Interventions: Drug: nicardipine
Drug: labetalol

First Posted Date: 2009-12-31

Last Posted Date: 2009-12-31

Lead Sponsor: Seoul National University Bundang Hospital

Target Recruit Count: 70

Registration Number: NCT01041066

Locations: 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

NICardipine Neuroprotection in AortiC Surgery (NICNACS)

Phase 2

Terminated

Conditions: Aortic Aneurysm, Thoracic

Interventions: Drug: Nicardipine
Drug: 0.9% saline

First Posted Date: 2007-07-27

Last Posted Date: 2014-08-01

Lead Sponsor: Duke University

Target Recruit Count: 7

Registration Number: NCT00508118

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Antihypertensive Treatment in Acute Cerebral Hemorrhage

Phase 1

Completed

Conditions: Hypertension
Intracerebral Hemorrhage
Stroke

Interventions: Drug: nicardipine

First Posted Date: 2006-12-25

Last Posted Date: 2017-11-21

Lead Sponsor: University of Minnesota

Target Recruit Count: 60

Registration Number: NCT00415610

Locations: 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
🇺🇸
Ohio State University, Columbus, Ohio, United States
🇺🇸
Columbia University Medical Center, New York, New York, United States

and more 9 locations

Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine

Phase 3

Conditions: Hypertension During Pre-Eclampsia

Interventions: Drug: URAPIDIL (EUPRESSYL*)
Drug: NICARDIPINE

First Posted Date: 2006-12-08

Last Posted Date: 2009-02-25

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 72

Registration Number: NCT00409253

Locations: 🇫🇷
Hôpital Saint-Jacques, CHU de Besançon, BESANçON, France
🇫🇷
Sihcus-Cmco, Schiltigheim, France
🇫🇷
Maternité A. PINARD, Nancy, France

and more 1 locations

IV Double and Triple Concentrated Nicardipine for Stroke and ICH

Phase 4

Conditions: Hypertension

First Posted Date: 2006-05-15

Last Posted Date: 2006-05-15

Lead Sponsor: OSF Healthcare System

Target Recruit Count: 50

Registration Number: NCT00325793

Locations: 🇺🇸
OSF Stroke Center, Peoria, Illinois, United States

Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage

Not Applicable

Completed

Conditions: CVA (Cerebrovascular Accident)
Cerebral Hemorrhage
Intracranial Hemorrhages

First Posted Date: 2005-09-26

Last Posted Date: 2008-06-26

Lead Sponsor: The George Institute

Target Recruit Count: 404

Registration Number: NCT00226096

Locations: 🇦🇺
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
🇦🇺
Royal Adelaide Hospital, Adelaide, South Australia, Australia
🇦🇺
Royal Melbourne Hospital, Melbourne, Victoria, Australia

and more 16 locations

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