Mepivacaine
- Generic Name
- Mepivacaine
- Brand Names
- Carbocaine, Carbocaine With Neocobefrin, Isocaine, Isocaine With Levonordefrin, Polocaine, Scandonest, Scandonest L, Scandonest Plain
- Drug Type
- Small Molecule
- Chemical Formula
- C15H22N2O
- CAS Number
- 96-88-8
- Unique Ingredient Identifier
- B6E06QE59J
- Background
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
- Indication
For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
- Associated Conditions
- Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN)
- Associated Therapies
- Local Anaesthesia therapy, Regional nerve block therapy, Lumbar epidural anesthesia therapy
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
- Conditions
- Pain
- Interventions
- First Posted Date
- 2012-04-10
- Last Posted Date
- 2020-11-17
- Lead Sponsor
- Ohio State University
- Target Recruit Count
- 100
- Registration Number
- NCT01574807
- Locations
- 🇺🇸
The Ohio State University College of Dentistry, Postle Hall, Columbus, Ohio, United States
Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients
- Conditions
- Renal Insufficiency, Chronic
- Interventions
- First Posted Date
- 2012-02-15
- Last Posted Date
- 2014-04-16
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 16
- Registration Number
- NCT01533545
- Locations
- 🇩🇰
Rigshospitalet, Copenhagen, Denmark
Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting
- First Posted Date
- 2012-01-31
- Last Posted Date
- 2019-11-20
- Lead Sponsor
- Centre Hospitalier Annecy Genevois
- Target Recruit Count
- 26
- Registration Number
- NCT01522534
- Locations
- 🇫🇷
Centre Hospitalier Sallanches Chamonix, Sallanches, France
🇫🇷Centre Hospitalier Universitaire de GRENOBLE, Grenoble, France
🇫🇷Centre Hospitalier d'Albertville moutiers, Albertville, France
Dosage of Mepivacaine in Ultrasound Axillary Block
- Conditions
- Nerve BlockNeuromuscular BlockadeAnesthesia
- Interventions
- First Posted Date
- 2011-12-05
- Last Posted Date
- 2011-12-08
- Lead Sponsor
- Wayne State University
- Target Recruit Count
- 64
- Registration Number
- NCT01485653
Local Anesthetics New Formulations: From Development to Clinical Tests
- Conditions
- Local Anesthetic Effectiveness
- First Posted Date
- 2009-12-16
- Last Posted Date
- 2010-01-20
- Lead Sponsor
- University of Campinas, Brazil
- Target Recruit Count
- 30
- Registration Number
- NCT01032798
- Locations
- 🇧🇷
University of Campinas, Campinas, Sao Paulo, Brazil
Ultrasound Guided Supraclavicular Nerve Block
- First Posted Date
- 2009-01-21
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 103
- Registration Number
- NCT00825786
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy
- Conditions
- Knee Arthroscopy
- Interventions
- First Posted Date
- 2008-12-05
- Last Posted Date
- 2010-01-26
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 34
- Registration Number
- NCT00803725
- Locations
- 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada
Drug Development Updates
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