Melatonin

Generic Name
Melatonin
Brand Names
Circadin, Slenyto, Melatonin Neurim
Drug Type
Small Molecule
Chemical Formula
C13H16N2O2
CAS Number
73-31-4
Unique Ingredient Identifier
JL5DK93RCL
Background

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...

Indication

Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...

Associated Conditions
Insomnia
Associated Therapies
-
Clinical Trials
Related News

MELATOX: Evaluation of Percutaneous Dissolvement of Melatonin When Used as Sunscreen; a Randomized, Placebo Controlled, Double-blind Crossover Study on Healthy Volunteers.

Phase 1
Completed
Conditions
Solar Skin Damage
Interventions
Drug: Placebo
Drug: Melatonin
First Posted Date
2014-08-25
Last Posted Date
2014-11-17
Lead Sponsor
Zealand University Hospital
Target Recruit Count
10
Registration Number
NCT02224937
Locations
🇩🇰

Herlev Sygehus, Herlev, Denmark

Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.

First Posted Date
2014-07-21
Last Posted Date
2014-07-21
Lead Sponsor
Hospital de Clinicas de Porto Alegre
Target Recruit Count
50
Registration Number
NCT02195271
Locations
🇧🇷

Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil

Comparison of Melatonin or Metformin and Dacarbazine Combination Versus Dacarbazine Alone in Disseminated Melanoma

Phase 2
Terminated
Conditions
Melanoma
Interventions
Drug: Metformin
Drug: Melatonin
Drug: Dacarbazine
First Posted Date
2014-07-15
Last Posted Date
2019-11-25
Lead Sponsor
N.N. Petrov National Medical Research Center of Oncology
Target Recruit Count
57
Registration Number
NCT02190838
Locations
🇷🇺

N.N. Petrov Research Institute of Oncology Ambulatory Chemotherapy Department, St. Petersburg, Russian Federation

🇷🇺

N.N. Petrov Research Institute of Oncology Chemotherapy and Innovative Technologies Department, St. Petersburg, Russian Federation

🇷🇺

N.N. Petrov Research Institute of Oncology Clinical Diagnostic Department, St.Petersburg, Russian Federation

The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers.

Not Applicable
Completed
Conditions
Pharmacokinetics of Melatonin
Interventions
Drug: Melatonin
First Posted Date
2014-04-08
Last Posted Date
2014-04-08
Lead Sponsor
Utrecht University
Target Recruit Count
10
Registration Number
NCT02107079
Locations
🇳🇱

Pharmacy department of faculty of veterinary medicine Utrecht University, Utrecht, Netherlands

Cardiac Surgery and the Risk of Atrial Fibrillation: an Intervention Trial Evaluating Melatonin

First Posted Date
2014-03-28
Last Posted Date
2021-08-12
Lead Sponsor
Johns Hopkins University
Registration Number
NCT02099331
Locations
🇺🇸

Johns Hopkins Hospital, Baltimore, Maryland, United States

Melatonin for Neuroprotection Following Perinatal Asphyxia

Phase 1
Completed
Conditions
Perinatal Asphyxia
Interventions
Drug: Melatonin
First Posted Date
2014-02-25
Last Posted Date
2014-02-25
Lead Sponsor
Tanta University
Target Recruit Count
45
Registration Number
NCT02071160
Locations
🇪🇬

Tanta University Children's Hospital, Tanta, Gharbeya, Egypt

Does Melatonin Restore Sleep Architecture in Autistic Children

Phase 2
Completed
Conditions
Sleep Disorders
Interventions
Drug: placebo
Drug: Melatonin
First Posted Date
2013-11-25
Last Posted Date
2019-01-28
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
26
Registration Number
NCT01993251
Locations
🇫🇷

CHU de Caen, Caen, France

🇫🇷

Hôpital Femme Mere Enfant, Bron, France

🇫🇷

Centre Hospitalier du Chinonais, Chinon, France

and more 2 locations

Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer

First Posted Date
2013-10-18
Last Posted Date
2017-06-16
Lead Sponsor
Juravinski Cancer Center
Target Recruit Count
100
Registration Number
NCT01965522
Locations
🇨🇦

St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

🇨🇦

Juravinski Cancer Center, Hamilton, Ontario, Canada

Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders

First Posted Date
2013-08-14
Last Posted Date
2017-01-24
Lead Sponsor
Southeast Renal Research Institute
Target Recruit Count
53
Registration Number
NCT01922999
Locations
🇺🇸

Southeast Renal Research Institute, Chattanooga, Tennessee, United States

Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy

First Posted Date
2013-07-22
Last Posted Date
2015-07-03
Lead Sponsor
St. Louis University
Registration Number
NCT01904786
Locations
🇺🇸

Cardinal Glennnon Children's Medical Center, St. Louis, Missouri, United States

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