Melatonin

Generic Name
Melatonin
Brand Names
Circadin, Slenyto, Melatonin Neurim
Drug Type
Small Molecule
Chemical Formula
C13H16N2O2
CAS Number
73-31-4
Unique Ingredient Identifier
JL5DK93RCL
Background

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...

Indication

Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...

Associated Conditions
Insomnia
Associated Therapies
-
Clinical Trials
Related News

Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients

Phase 2
Completed
Conditions
Head and Neck Cancer
Interventions
Drug: Matched Placebo
Drug: Melatonin
First Posted Date
2015-04-30
Last Posted Date
2016-02-24
Lead Sponsor
Khon Kaen University
Target Recruit Count
39
Registration Number
NCT02430298
Locations
🇹🇭

Ubon Ratchathani Cancer Hospital, Ubon Ratchathani, Thailand

The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery

First Posted Date
2015-04-22
Last Posted Date
2017-04-27
Lead Sponsor
Sheba Medical Center
Target Recruit Count
60
Registration Number
NCT02424071
Locations
🇮🇱

Sheba Medical Center, Ramat Gan, Israel

Anxiolytic and Analgesic Effects of Melatonin

Phase 3
Completed
Conditions
Anxiety
Interventions
Drug: Melatonin
Drug: Placebo
First Posted Date
2015-03-11
Last Posted Date
2021-09-02
Lead Sponsor
Herlev Hospital
Target Recruit Count
36
Registration Number
NCT02386319
Locations
🇩🇰

Herlev Hospital, Herlev, Denmark

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Melatonin for Nocturia in Parkinson's Disease

Phase 2
Conditions
Nocturia
Parkinson's Disease
Interventions
Drug: Melatonin
First Posted Date
2015-02-10
Last Posted Date
2015-02-10
Lead Sponsor
University College, London
Target Recruit Count
20
Registration Number
NCT02359448
Locations
🇬🇧

National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, United Kingdom

Bringing Relief to Adolescents Naturally Using Melatonin for Migraine

Phase 2
Completed
Conditions
Migraine in Adolescents
Interventions
Other: Placebo
Drug: Melatonin
First Posted Date
2015-01-22
Last Posted Date
2021-09-09
Lead Sponsor
Amy Gelfand
Target Recruit Count
31
Registration Number
NCT02344316
Locations
🇺🇸

UCLA Headache Research and Treatment Program, Los Angeles, California, United States

🇺🇸

UCSF Pediatric Brain Center, San Francisco, California, United States

Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy

Phase 3
Terminated
Conditions
Breast Cancer - Female
Interventions
Drug: Placebo
Drug: Melatonin
First Posted Date
2015-01-07
Last Posted Date
2023-03-30
Lead Sponsor
Virginia Commonwealth University
Target Recruit Count
80
Registration Number
NCT02332928
Locations
🇺🇸

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

Dose Assessment of Melatonin in Sepsis Trial

Phase 1
Withdrawn
Conditions
Sepsis
Interventions
Drug: Melatonin
First Posted Date
2014-12-18
Last Posted Date
2017-04-21
Lead Sponsor
University of Aberdeen
Registration Number
NCT02319265
Locations
🇬🇧

Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom

Melatonin for Delirium Prophylaxis

Phase 4
Withdrawn
Conditions
Delirium
Interventions
Other: Placebo
Drug: Melatonin
First Posted Date
2014-11-04
Last Posted Date
2021-10-07
Lead Sponsor
University of British Columbia
Registration Number
NCT02282241
Locations
🇨🇦

Vancouver Coastal Health, Vancouver, British Columbia, Canada

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

First Posted Date
2014-09-26
Last Posted Date
2024-08-23
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
143
Registration Number
NCT02251041
Locations
🇧🇪

University Hospitals Leuven, Leuven, Belgium

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