Melatonin

Generic Name: Melatonin

Brand Names: Circadin, Slenyto, Melatonin Neurim

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂O_₂

CAS Number: 73-31-4

Unique Ingredient Identifier: JL5DK93RCL

Background: Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...

Indication: Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...

Associated Conditions: Insomnia

Associated Therapies: -

Clinical Trials

The Sun Protective Effect of Melatonin

Phase 1

Completed

Conditions: Sunburn

Interventions: Drug: Melatonin

First Posted Date: 2013-06-10

Last Posted Date: 2013-08-29

Lead Sponsor: Herlev Hospital

Target Recruit Count: 22

Registration Number: NCT01873430

Locations: 🇩🇰
Gastroenheden, Herlev Hospital, Herlev, Denmark

Safety Study of Melatonin in Stroke Patients

Phase 4

Conditions: Acute Ischemic Stroke

Interventions: Drug: Melatonin
Drug: placebo

First Posted Date: 2013-05-27

Last Posted Date: 2013-05-27

Lead Sponsor: Wolfson Medical Center

Target Recruit Count: 140

Registration Number: NCT01863277

Locations: 🇮🇱
E. Wolfson Medical Center, Holon, Israel

Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.

Phase 3

Conditions: Evidence of Liver Transplantation

Interventions: Drug: Placebo
Drug: Melatonin

First Posted Date: 2013-05-23

Last Posted Date: 2013-05-23

Lead Sponsor: Aragon Institute of Health Sciences

Target Recruit Count: 60

Registration Number: NCT01860716

Locations: 🇪🇸
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock

Phase 3

Conditions: Severe Sepsis
Septic Shock

Interventions: Drug: Melatonin

First Posted Date: 2013-05-21

Last Posted Date: 2013-05-21

Lead Sponsor: Aragon Institute of Health Sciences

Target Recruit Count: 110

Registration Number: NCT01858909

Locations: 🇪🇸
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

Phase I Dose Finding Study for Melatonin in Pediatric Oncology Patients With Relapsed Solid Tumors

Phase 1

Completed

Conditions: Relapsed Malignant Solid Tumor

Interventions: Drug: Melatonin

First Posted Date: 2013-05-21

Last Posted Date: 2019-01-31

Lead Sponsor: C17 Council

Target Recruit Count: 9

Registration Number: NCT01858155

Locations: 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇨🇦
Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada
🇨🇦
Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada

and more 2 locations

Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics

Phase 4

Completed

Conditions: Second Generation Antipsychotic Induced Metabolic Adverse Effects

Interventions: Drug: Placebo
Drug: Melatonin

First Posted Date: 2013-03-14

Last Posted Date: 2013-03-14

Lead Sponsor: Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente

Target Recruit Count: 50

Registration Number: NCT01811160

Locations: 🇲🇽
Instituto Nacional de Psiquiatría "Dr. Ramón de la Fuente", Mexico City, México City, Mexico

Melatonin Dose-effect Relation in Childhood Autism

Phase 2

Completed

Conditions: Childhood Autism

Interventions: Drug: melatonin
Drug: Placebo

First Posted Date: 2013-01-31

Last Posted Date: 2023-05-23

Lead Sponsor: Rennes University Hospital

Target Recruit Count: 34

Registration Number: NCT01780883

Locations: 🇫🇷
Service de Psychiatrie de l'Enfant et de l'Adolescent - Hôpital de la Pitié-Salpêtrière, Paris, France
🇫🇷
Centre Hospitalier Spécialisé Henri Laborit, Poitiers, France
🇫🇷
Service de Psychothérapie de l'Enfant et de l'Adolescent - Hôpital Robert Debré, Reims, France

and more 1 locations

Melatonin in Healthy Volunteers

Phase 1

Completed

Conditions: Sepsis

Interventions: Drug: Melatonin

First Posted Date: 2012-11-09

Last Posted Date: 2013-05-09

Lead Sponsor: University of Aberdeen

Target Recruit Count: 20

Registration Number: NCT01724424

Locations: 🇬🇧
University of Aberdeen, Aberdeen, Scoltand, United Kingdom

Effect of Melatonin on Multiple Sclerosis Related Fatigue

Phase 2

Completed

Conditions: Fatigue

Interventions: Drug: Placebo
Drug: Melatonin

First Posted Date: 2012-10-31

Last Posted Date: 2012-10-31

Lead Sponsor: Isfahan University of Medical Sciences

Target Recruit Count: 44

Registration Number: NCT01718678

Locations: 🇮🇷
Al-zahra university hospital, Isfahan, Iran, Islamic Republic of

Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene

Phase 3

Completed

Conditions: Diabetes
Glucose Tolerance

Interventions: Drug: Melatonin

First Posted Date: 2012-10-12

Last Posted Date: 2017-01-04

Lead Sponsor: University of Helsinki

Target Recruit Count: 45

Registration Number: NCT01705639

Locations: 🇫🇮
Vasa health care centre, Vasa, Finland
🇫🇮
Botniacentret Jakobstad, Jakobstad, Finland

Drug Development Updates

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