Melatonin
- Generic Name
- Melatonin
- Brand Names
- Circadin, Slenyto, Melatonin Neurim
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2O2
- CAS Number
- 73-31-4
- Unique Ingredient Identifier
- JL5DK93RCL
- Background
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...
- Indication
Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...
- Associated Conditions
- Insomnia
- Associated Therapies
- -
Pilot Study of Melatonin and Epilepsy
- First Posted Date
- 2009-08-25
- Last Posted Date
- 2020-10-01
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 11
- Registration Number
- NCT00965575
- Locations
- 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer
- First Posted Date
- 2009-06-22
- Last Posted Date
- 2017-04-20
- Lead Sponsor
- Bispebjerg Hospital
- Target Recruit Count
- 72
- Registration Number
- NCT00925899
- Locations
- 🇩🇰
Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark
The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease
- First Posted Date
- 2009-06-08
- Last Posted Date
- 2009-06-08
- Lead Sponsor
- Mansoura University
- Registration Number
- NCT00915616
Melatonin for Circadian Sleep Disorders in the Blind
- Conditions
- Interventions
- First Posted Date
- 2009-06-01
- Last Posted Date
- 2019-11-27
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 59
- Registration Number
- NCT00911053
- Locations
- 🇺🇸
Oregon Health and Science University, Portland, Oregon, United States
Melatonin Supplementation to Improve Sleep in Patients With Heart Failure
- First Posted Date
- 2009-03-26
- Last Posted Date
- 2018-01-19
- Lead Sponsor
- Brigham and Women's Hospital
- Registration Number
- NCT00869869
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
- Conditions
- Interventions
- First Posted Date
- 2009-03-23
- Last Posted Date
- 2012-03-16
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 8
- Registration Number
- NCT00867451
- Locations
- 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Melatonin for Migraine Prevention
- First Posted Date
- 2009-02-24
- Last Posted Date
- 2014-09-25
- Lead Sponsor
- Nordlandssykehuset HF
- Target Recruit Count
- 48
- Registration Number
- NCT00849511
- Locations
- 🇳🇴
Departement of Neurology, NLSH HF, Bodø, Norway
🇳🇴Departement of Neurology, Tromsø, Norway
Melatonin Studies of Totally Blind Children
- First Posted Date
- 2008-11-21
- Last Posted Date
- 2019-11-27
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 13
- Registration Number
- NCT00795236
- Locations
- 🇺🇸
Oregon Health and Science University, Portland, Oregon, United States
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial
- First Posted Date
- 2008-11-13
- Last Posted Date
- 2021-02-12
- Lead Sponsor
- Emory University
- Target Recruit Count
- 3
- Registration Number
- NCT00790478
- Locations
- 🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸Consultative Gastroenterology, Atlanta, Georgia, United States
Effects of Melatonin and Oxygen Consumption and Choroidal Blood Flow
- First Posted Date
- 2008-05-08
- Last Posted Date
- 2012-09-11
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 16
- Registration Number
- NCT00675181
- Locations
- 🇨🇭
University Eye Clinic, Basel, Switzerland
Drug Development Updates
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