Melatonin
- Generic Name
- Melatonin
- Brand Names
- Circadin, Slenyto, Melatonin Neurim
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2O2
- CAS Number
- 73-31-4
- Unique Ingredient Identifier
- JL5DK93RCL
- Background
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...
- Indication
Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...
- Associated Conditions
- Insomnia
- Associated Therapies
- -
The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty
- First Posted Date
- 2008-03-20
- Last Posted Date
- 2020-07-22
- Lead Sponsor
- Alberto Domínguez Rodríguez
- Target Recruit Count
- 272
- Registration Number
- NCT00640094
- Locations
- 🇪🇸
Hospital Universitario Marqués de Valdecilla, Santander, Spain
🇪🇸University Hospital of Canarias, La Laguna, Tenerife, Spain
🇪🇸Hospital General Universitario Santa Lucia, Cartagena, Murcia, Spain
Multimodal Treatment Strategy for Cancer Cachexia
- Conditions
- Interventions
- First Posted Date
- 2008-02-28
- Last Posted Date
- 2016-02-12
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 15
- Registration Number
- NCT00625742
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
SThe Effects of Melatonin on GERD Symptoms
- Conditions
- Interventions
- First Posted Date
- 2007-11-28
- Last Posted Date
- 2007-11-28
- Lead Sponsor
- Rabin Medical Center
- Target Recruit Count
- 150
- Registration Number
- NCT00564590
- Locations
- 🇮🇱
Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
The Effect of Melatonin on Cognitive Function in Patients Diagnosed With Mild Cognitive Impairment
- Conditions
- Interventions
- First Posted Date
- 2007-10-16
- Last Posted Date
- 2007-10-16
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT00544791
- Locations
- 🇮🇱
Memory clinic, 'Asaf Harofeh' medical center, Zerifin, Israel
Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2007-08-08
- Last Posted Date
- 2012-12-11
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 82
- Registration Number
- NCT00513357
- Locations
- 🇺🇸
Joan Karnell Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸UT MD Anderson Cancer Center, Houston, Texas, United States
Melatonin Postoperative Sleep Study in Breast Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2007-07-25
- Last Posted Date
- 2012-12-05
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 4
- Registration Number
- NCT00506064
- Locations
- 🇺🇸
U.T.M.D. Anderson Cancer Center, Houston, Texas, United States
The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients
- Conditions
- First Posted Date
- 2006-11-28
- Last Posted Date
- 2008-01-29
- Lead Sponsor
- Meander Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT00404456
- Locations
- 🇳🇱
Meander Medical Center, Amersfoort, Netherlands
Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders
- Conditions
- Interventions
- First Posted Date
- 2006-10-12
- Last Posted Date
- 2009-08-25
- Target Recruit Count
- 48
- Registration Number
- NCT00387179
- Locations
- 🇺🇸
Sleep and Chronobiology Laboratory, Boulder, Colorado, United States
Melatonin and Cardiac Outcome After Major Surgery
- First Posted Date
- 2006-04-19
- Last Posted Date
- 2010-06-30
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Target Recruit Count
- 52
- Registration Number
- NCT00315926
- Locations
- 🇩🇰
Department of Surgical Gastroenterology, University Hospital of Copenhagen in Gentofte, Hellerup, Denmark
Synchronization and Desynchronization Between Circadian Rhythms in Patients With Delayed Sleep Phase Syndrome (DSPS)
- Conditions
- First Posted Date
- 2006-01-25
- Last Posted Date
- 2006-12-15
- Lead Sponsor
- Sheba Medical Center
- Registration Number
- NCT00282061
- Locations
- 🇮🇱
The Institute for Sleep and Fatigue Medicine, Sheba Medical Center, Tel Hashomer, Israel
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.