Acetylcysteine
- Generic Name
- Acetylcysteine
- Brand Names
- Acetadote
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3S
- CAS Number
- 616-91-1
- Unique Ingredient Identifier
- WYQ7N0BPYC
- Background
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.
Acetylcysteine was granted FDA approval on 14 September 1963.
- Indication
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
- Associated Conditions
- Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
- Associated Therapies
- Airway secretion clearance therapy
Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC
- Conditions
- Interventions
- First Posted Date
- 2014-10-08
- Last Posted Date
- 2015-05-01
- Lead Sponsor
- Otologic Pharmaceutics, Inc.
- Target Recruit Count
- 32
- Registration Number
- NCT02259595
- Locations
- 🇺🇸
Wake Research Associates, Raleigh, North Carolina, United States
THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS
- First Posted Date
- 2014-09-16
- Last Posted Date
- 2014-09-16
- Lead Sponsor
- University of Campinas, Brazil
- Target Recruit Count
- 60
- Registration Number
- NCT02241876
- Locations
- 🇧🇷
State University of Campinas - UNICAMP, Hospital das Clinicas, Campinas, São Paulo, Brazil
Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient
- Conditions
- Interventions
- First Posted Date
- 2014-06-20
- Last Posted Date
- 2015-03-03
- Lead Sponsor
- Duke University
- Target Recruit Count
- 39
- Registration Number
- NCT02168387
Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation
- Conditions
- Interventions
- First Posted Date
- 2014-06-09
- Last Posted Date
- 2017-06-16
- Target Recruit Count
- 950
- Registration Number
- NCT02159196
- Locations
- 🇳🇱
Rijnstate Ziekenhuis, Arnhem, Netherlands
🇳🇱MC Haaglanden, Den Haag, Netherlands
🇳🇱Onze Lieve Vrouwe Gasthuis, Amsterdam, Noord Holland, Netherlands
n-Acetylcysteine and Cocaine
- Conditions
- Interventions
- First Posted Date
- 2014-05-19
- Last Posted Date
- 2017-01-04
- Lead Sponsor
- University of Kentucky
- Target Recruit Count
- 15
- Registration Number
- NCT02141620
- Locations
- 🇺🇸
University of Kentucky Laboratory of Human Behavioral Pharmacology, Lexington, Kentucky, United States
N-acetylcysteine for Tobacco Smoking
- First Posted Date
- 2014-04-28
- Last Posted Date
- 2014-04-28
- Lead Sponsor
- Universidade Estadual de Londrina
- Target Recruit Count
- 32
- Registration Number
- NCT02124525
- Locations
- 🇧🇷
Hospital das Clínicas da Universidade Estadual de Londrina (Londrina State University Clinical Hospital), Londrina, PR, Brazil
Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy
- Conditions
- Recurrent Squamous Cell Carcinoma of the NasopharynxStage I Squamous Cell Carcinoma of the Lip and Oral CavityStage I Verrucous Carcinoma of the LarynxMucositisRecurrent Basal Cell Carcinoma of the LipRecurrent Mucoepidermoid Carcinoma of the Oral CavityRecurrent Salivary Gland CancerRecurrent Verrucous Carcinoma of the LarynxOral ComplicationsRecurrent Lymphoepithelioma of the Oropharynx
- Interventions
- First Posted Date
- 2014-04-25
- Last Posted Date
- 2019-04-30
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 34
- Registration Number
- NCT02123511
- Locations
- 🇺🇸
Mayo Clinic in Arizona, Scottsdale, Arizona, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
🇺🇸State University of New York Upstate Medical University, Syracuse, New York, United States
NAC to Prevent Cisplatin-induced Hearing Loss
- Conditions
- Interventions
- First Posted Date
- 2014-03-24
- Last Posted Date
- 2023-04-18
- Lead Sponsor
- Children's Hospital Los Angeles
- Target Recruit Count
- 52
- Registration Number
- NCT02094625
- Locations
- 🇺🇸
Childrens Hospital Los Angeles, Los Angeles, California, United States
Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy
- Conditions
- Interventions
- First Posted Date
- 2014-03-17
- Last Posted Date
- 2014-03-17
- Lead Sponsor
- Isfahan University of Medical Sciences
- Target Recruit Count
- 96
- Registration Number
- NCT02088502
- Locations
- 🇮🇷
Chamran Hospital, Isfahan, Iran, Islamic Republic of
Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis
- Conditions
- Interventions
- First Posted Date
- 2014-03-14
- Last Posted Date
- 2019-03-14
- Lead Sponsor
- Qilu Hospital of Shandong University
- Target Recruit Count
- 161
- Registration Number
- NCT02088216
- Locations
- 🇨🇳
Qilu Hospital of Shandong University, Jinan, Shandong, China
Drug Development Updates
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