Acetylcholine

Generic Name
Acetylcholine
Brand Names
Miochol
Drug Type
Small Molecule
Chemical Formula
C7H16NO2
CAS Number
51-84-3
Unique Ingredient Identifier
N9YNS0M02X
Background

A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, bu...

Indication

Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.

Associated Conditions
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Associated Therapies
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The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood Flow

First Posted Date
2021-03-02
Last Posted Date
2021-03-02
Lead Sponsor
University Hospital, Linkoeping
Target Recruit Count
90
Registration Number
NCT04777383
Locations
🇸🇪

University Hospital Linköping, Linköping, Östergötland, Sweden

Targeting ER Stress in Vascular Dysfunction

First Posted Date
2019-06-28
Last Posted Date
2024-07-31
Lead Sponsor
Colorado State University
Target Recruit Count
17
Registration Number
NCT04001647
Locations
🇺🇸

Colorado State University, Fort Collins, Colorado, United States

Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training

First Posted Date
2019-06-04
Last Posted Date
2021-08-02
Lead Sponsor
Colorado State University
Registration Number
NCT03972683
Locations
🇺🇸

Colorado State University, Fort Collins, Colorado, United States

HeartPhone Cancer Survivors Trial 2019

First Posted Date
2019-05-16
Last Posted Date
2021-02-02
Lead Sponsor
Penn State University
Target Recruit Count
3
Registration Number
NCT03953326
Locations
🇺🇸

The Pennsylvania State University, University Park, Pennsylvania, United States

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

First Posted Date
2018-11-13
Last Posted Date
2021-07-27
Lead Sponsor
Colorado State University
Target Recruit Count
9
Registration Number
NCT03738943
Locations
🇺🇸

Human Performance and Clinical Research Laboratory, Fort Collins, Colorado, United States

Pharmacodynamic Study to Assess the Effects of Repeated Dosing of SAR247799 on Endothelial Function in Patients With Type 2 Diabetes Mellitus

First Posted Date
2018-03-12
Last Posted Date
2022-04-25
Lead Sponsor
Sanofi
Target Recruit Count
54
Registration Number
NCT03462017
Locations
🇩🇪

Investigational Site Number 2760001, Neuss, Germany

🇩🇪

Investigational Site Number 2760002, Mainz, Germany

Anemia Study in Chronic Kidney Disease (CKD) : Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat -Forearm Blood Flow (ASCEND-FBF)

First Posted Date
2018-02-27
Last Posted Date
2024-03-27
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
6
Registration Number
NCT03446612
Locations
🇬🇧

GSK Investigational Site, London, United Kingdom

Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease.

First Posted Date
2016-12-09
Last Posted Date
2024-02-07
Lead Sponsor
Cambridge University Hospitals NHS Foundation Trust
Target Recruit Count
29
Registration Number
NCT02987465
Locations
🇬🇧

Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom

Vascular Function and Uterine Fibroids

First Posted Date
2014-04-25
Last Posted Date
2018-03-02
Lead Sponsor
Mayo Clinic
Target Recruit Count
28
Registration Number
NCT02123069
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Endothelial Injury and Development of Coronary Intimal Thickening After Heart Transplantation

First Posted Date
2013-05-07
Last Posted Date
2017-09-06
Lead Sponsor
Gladwin, Mark, MD
Target Recruit Count
12
Registration Number
NCT01848301
Locations
🇺🇸

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

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