Methylprednisolone hemisuccinate

Generic Name: Methylprednisolone hemisuccinate

Brand Names: Solu-medrol

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₃₄O_₈

CAS Number: 2921-57-5

Unique Ingredient Identifier: 5GMR90S4KN

Background: A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Associated Conditions: Acute Gouty Arthritis, Ankylosing Spondylitis (AS), Berylliosis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatitis bullous, Dermatomyositis (DM), Edema of the cerebrum, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Leukemias, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Pemphigus, Polymyositis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Refractory Uveitis, Regional Enteritis, Rheumatoid Arthritis, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Allergic Reactions, Symptomatic Sarcoidosis

Associated Therapies: Palliative Treatment

Clinical Trials

Efficacy Of Magnesium In Radicular Pain When Added To Local Anesthetics And Steroids In Transforaminal Epidural Injection

Phase 1

Conditions: Pain
Neuropathy

Interventions: Drug: magnesium
Drug: Methylprednisolone
Drug: Bupivacaine Hydrochloride
Drug: saline 0.9%

First Posted Date: 2020-08-31

Last Posted Date: 2020-08-31

Lead Sponsor: Fayoum University

Target Recruit Count: 100

Registration Number: NCT04532775

Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection

Phase 3

Conditions: Covid19
SARS-CoV Infection
Coagulopathy
Pneumonia, Viral

Interventions: Drug: Enoxaparin
Drug: Methylprednisolone
Drug: unfractionated heparin

First Posted Date: 2020-08-27

Last Posted Date: 2021-05-06

Lead Sponsor: Massimo Girardis

Target Recruit Count: 210

Registration Number: NCT04528888

Locations: 🇮🇹
ICU- University Hospital Modena, Modena, Italy

Thyroid and Adrenocortical Hormone Replacement in Organ Donors

Not Applicable

Completed

Conditions: Brain Death

Interventions: Drug: Levothyroxine
Drug: Methylprednisolone

First Posted Date: 2020-08-27

Last Posted Date: 2020-08-27

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 199

Registration Number: NCT04528797

Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.

Phase 1

Recruiting

Conditions: Refractory Multiple Myeloma

Interventions: Drug: Selinexor
Drug: Lenalidomide
Drug: Methylprednisolone

First Posted Date: 2020-08-19

Last Posted Date: 2023-10-31

Lead Sponsor: Oncotherapeutics

Target Recruit Count: 22

Registration Number: NCT04519476

Locations: 🇺🇸
James R Berenson, MD, Inc., West Hollywood, California, United States

Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19

Phase 3

Conditions: Covid19
ARDS

Interventions: Drug: Methylprednisolone
Drug: Dexamethasone

First Posted Date: 2020-08-05

Last Posted Date: 2020-08-18

Lead Sponsor: Chattogram General Hospital

Target Recruit Count: 60

Registration Number: NCT04499313

Locations: 🇧🇩
Chattogram General Hospital, Chittagong, Bangladesh
🇧🇩
M. Abdur Rahim Medical College Hospital, Dinajpur, Bangladesh

Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia

Phase 3

Withdrawn

Conditions: COVID-19

Interventions: Drug: Methylprednisolone
Drug: Heparin

First Posted Date: 2020-07-24

Last Posted Date: 2021-08-11

Lead Sponsor: D'Or Institute for Research and Education

Registration Number: NCT04485429

Locations: 🇧🇷
D'Or Institute for Research and Education, Rio de Janeiro, Brazil

Triamcinolone Versus Methylprednisolone in Transversus Abdominis Plane Block

Phase 2

Completed

Conditions: Major Abdominal Surgery

Interventions: Drug: bupivacaine
Drug: Triamcinolone
Drug: Methylprednisolone

First Posted Date: 2020-07-21

Last Posted Date: 2021-03-03

Lead Sponsor: ghada fouad

Target Recruit Count: 84

Registration Number: NCT04480775

Locations: 🇪🇬
Mansoura University, Mansoura, Egypt

Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphoma

Phase 2

Recruiting

Conditions: Diffuse Large B-Cell Lymphoma
High Grade B-Cell Lymphoma w/MYC & BCL2 or BCL6 Rearrangements
High Grade B-Cell Lymphoma w/MYC, BCL2 & BCL6 Rearrangements
Double Expressor Lymphoma
High-grade B-cell Lymphoma

Interventions: Drug: Prednisone
Drug: Prednisolone
Drug: Methylprednisolone
Biological: Rituximab
Drug: Polatuzumab Vedotin
Drug: Cyclophosphamide
Drug: Doxorubicin Hydrochloride

First Posted Date: 2020-07-21

Last Posted Date: 2024-03-20

Lead Sponsor: Barbara Ann Karmanos Cancer Institute

Target Recruit Count: 49

Registration Number: NCT04479267

Locations: 🇺🇸
Karmanos Cancer Institute, Detroit, Michigan, United States

Low Versus High Corticosteroid Use in Ventilator Associated Pneumonia

Phase 2

Completed

Conditions: Ventilator Associated Pneumonia

Interventions: Drug: Methyl Prednisolonate
Drug: methylprednisolone
Device: ventilators

First Posted Date: 2020-07-13

Last Posted Date: 2020-07-13

Lead Sponsor: King Abdul Aziz Specialist Hospital

Target Recruit Count: 240

Registration Number: NCT04467892

Locations: 🇸🇦
King abd el Aziz specialist hospital, Ta'if, Saudi Arabia

Glucocorticoids in COVID-19 (CORTIVID)

Phase 3

Completed

Conditions: Covid-19 Pneumonia

Interventions: Other: Placebo
Drug: Methylprednisolone

First Posted Date: 2020-06-19

Last Posted Date: 2021-05-17

Lead Sponsor: Fundacion Miguel Servet

Target Recruit Count: 72

Registration Number: NCT04438980

Locations: 🇪🇸
Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
🇪🇸
Hospital Sant Joan Despí Moisès Broggi, Sant Joan Despí, Barcelona, Spain

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