Losartan
- Generic Name
- Losartan
- Brand Names
- Hyzaar, Cozaar
- Drug Type
- Small Molecule
- Chemical Formula
- C22H23ClN6O
- CAS Number
- 114798-26-4
- Unique Ingredient Identifier
- JMS50MPO89
- Background
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Los...
- Indication
Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hyper...
- Associated Conditions
- Diabetic Nephropathy, Ventricular Dysfunction, Hypertension, Marfan Syndrome, Ischemic Stroke
- Associated Therapies
- -
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
- First Posted Date
- 2014-07-11
- Last Posted Date
- 2023-01-30
- Lead Sponsor
- Mclean Hospital
- Target Recruit Count
- 227
- Registration Number
- NCT02188121
- Locations
- 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States
Telmisartan With or Without Hydrochlorothiazide (HCTZ) Compared With Losartan With or Without HCTZ in Mild to Moderate Hypertensive Patients
- Conditions
- Interventions
- First Posted Date
- 2014-06-24
- Last Posted Date
- 2014-06-24
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 363
- Registration Number
- NCT02172586
Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2014-04-23
- Last Posted Date
- 2017-02-10
- Lead Sponsor
- Anthony J Viera, MD, MPH
- Target Recruit Count
- 28
- Registration Number
- NCT02121041
- Locations
- 🇺🇸
University of North Carolina, Chapel Hill, North Carolina, United States
Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis
- First Posted Date
- 2014-02-14
- Last Posted Date
- 2015-07-01
- Lead Sponsor
- Chinese PLA General Hospital
- Target Recruit Count
- 720
- Registration Number
- NCT02063100
- Locations
- 🇨🇳
National Clinical Research Center for Kidney Disease, State Key Laboratory of Kidney Disease, Department of Nephrology, Chinese PLA General Hospital, Beijing, Beijing, China
🇨🇳Beijing Friendship,Capital Medical University, Beijing, Beijing, China
🇨🇳Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing, China
Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone System
- Conditions
- Interventions
- First Posted Date
- 2013-12-13
- Last Posted Date
- 2015-12-22
- Target Recruit Count
- 120
- Registration Number
- NCT02010905
- Locations
- 🇳🇱
Academic Medical Center, Amsterdam, Netherlands
🇳🇱St Antonius ziekenhuis, Nieuwegein, Netherlands
🇳🇱Universitair Medisch Centrum Groningen, Groningen, Netherlands
A Study of Muscle Strength Maintenance in Older Adults
- First Posted Date
- 2013-11-21
- Last Posted Date
- 2018-06-12
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 37
- Registration Number
- NCT01989793
- Locations
- 🇺🇸
Johns Hopkins Bayview Clinical Research Unit, Baltimore, Maryland, United States
Losartan for Sickle Cell Kidney Disease
- First Posted Date
- 2013-11-20
- Last Posted Date
- 2017-07-17
- Lead Sponsor
- Emory University
- Target Recruit Count
- 24
- Registration Number
- NCT01989078
- Locations
- 🇺🇸
Children's Healthcare of Atlanta, Atlanta, Georgia, United States
🇺🇸Grady Health Systems, Atlanta, Georgia, United States
Cardiomyopathy in DMD: Lisinopril vs. Losartan
- Conditions
- Interventions
- First Posted Date
- 2013-11-13
- Last Posted Date
- 2017-03-21
- Lead Sponsor
- Nationwide Children's Hospital
- Target Recruit Count
- 23
- Registration Number
- NCT01982695
- Locations
- 🇺🇸
University of California Davis, Davis, California, United States
🇺🇸Boston Children's Hospital, Boston, Massachusetts, United States
🇺🇸St. Louis Children's Hospital, St. Louise, Missouri, United States
Comparision of Blood Pressure Variability Between Amlodipine and Losartan
- First Posted Date
- 2013-10-17
- Last Posted Date
- 2017-05-12
- Lead Sponsor
- Wonju Severance Christian Hospital
- Target Recruit Count
- 144
- Registration Number
- NCT01964079
- Locations
- 🇰🇷
Wonju Severance Christian Hospital, Wonju, Gangwon-do, Korea, Republic of
Study of Losartan in the Treatment of NAFLD in Children
- First Posted Date
- 2013-08-01
- Last Posted Date
- 2017-05-15
- Lead Sponsor
- Miriam Vos, MD
- Target Recruit Count
- 12
- Registration Number
- NCT01913470
- Locations
- 🇺🇸
Emory University / Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Drug Development Updates
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