Losartan

Generic Name: Losartan

Brand Names: Hyzaar, Cozaar

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₃ClN_₆O

CAS Number: 114798-26-4

Unique Ingredient Identifier: JMS50MPO89

Background: Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide. Patients taking losartan should have their renal function and potassium levels monitored. Losartan was granted FDA approval on 14 April 1995.

Indication: Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hypertension. Losartan with hydrochlorothiazide is indicated to treat hypertension and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage).

Associated Conditions: Diabetic Nephropathy, Ventricular Dysfunction, Hypertension, Marfan Syndrome, Ischemic Stroke

Clinical Trials

Antihypertensive Effect of Different Doses of Rostafuroxin in Comparison With Losartan

Phase 2

Completed

Conditions: Hypertension

Interventions: Drug: Losartan
Drug: Rostafuroxin

First Posted Date: 2017-07-14

Last Posted Date: 2023-02-21

Lead Sponsor: Windtree Therapeutics

Target Recruit Count: 240

Registration Number: NCT03217825

Locations: 🇨🇳
Cvie Therapeutics Limited, Taipei, Taiwan

Losartan and Inflammation in Cystic Fibrosis

Phase 2

Terminated

Conditions: Cystic Fibrosis

Interventions: Drug: placebo
Drug: Losartan

First Posted Date: 2017-07-02

Last Posted Date: 2020-11-27

Lead Sponsor: University of Miami

Target Recruit Count: 7

Registration Number: NCT03206788

Locations: 🇺🇸
University of Kansas, Kansas City, Kansas, United States
🇺🇸
University of Miami, Miller School of Medicine, Miami, Florida, United States
🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States

and more 1 locations

Matão Controlling Hypertension (MatCH Study): Rationale and Design

Early Phase 1

Conditions: Hypertension
Blood Pressure

Interventions: Drug: Captopril 25Mg, Hydrochlorothiazide 25Mg Oral Tablet,
Drug: Atenolol
Drug: Losartan potassium 50mg
Drug: Clonidine

First Posted Date: 2017-05-10

Last Posted Date: 2017-11-21

Lead Sponsor: Centro Neurológico de Pesquisa e Reabiitação, Brazil

Target Recruit Count: 15000

Registration Number: NCT03147092

Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function

Phase 3

Terminated

Conditions: Cerebral Small Vessel Diseases

Interventions: Drug: Amlodipine
Drug: Losartan
Drug: Atenolol

First Posted Date: 2017-03-17

Last Posted Date: 2023-03-09

Lead Sponsor: Ludwig-Maximilians - University of Munich

Target Recruit Count: 101

Registration Number: NCT03082014

Locations: 🇩🇪
Insitute for Stroke and Dementia Research, Munich, Germany
🇳🇱
Maastricht University Medical Center, Maastricht, Netherlands
🇬🇧
Centre for Clinical Brain Sciences, Edinburgh, Scotland, United Kingdom

and more 2 locations

An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)

Phase 2

Completed

Conditions: Eosinophilic Esophagitis

Interventions: Drug: Losartan Potassium

First Posted Date: 2017-01-24

Last Posted Date: 2020-09-09

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 15

Registration Number: NCT03029091

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
🇺🇸
University of California, San Diego, La Jolla, California, United States