Losartan
- Generic Name
- Losartan
- Brand Names
- Hyzaar, Cozaar
- Drug Type
- Small Molecule
- Chemical Formula
- C22H23ClN6O
- CAS Number
- 114798-26-4
- Unique Ingredient Identifier
- JMS50MPO89
- Background
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Los...
- Indication
Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hyper...
- Associated Conditions
- Diabetic Nephropathy, Ventricular Dysfunction, Hypertension, Marfan Syndrome, Ischemic Stroke
- Associated Therapies
- -
Comparison of Blood Pressure Lowering Effect Between Fimasartan and Losartan
- First Posted Date
- 2016-11-08
- Last Posted Date
- 2016-11-08
- Lead Sponsor
- Chuncheon Sacred Heart Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT02958631
Pilot Trial: the Safety and Feasibility of Losartan for Pulmonary Vein Stenosis
- First Posted Date
- 2016-05-11
- Last Posted Date
- 2019-07-30
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 40
- Registration Number
- NCT02769130
- Locations
- 🇨🇦
Hospital for Sick Children, Toronto, Ontario, Canada
Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study
- Conditions
- Interventions
- First Posted Date
- 2016-05-03
- Last Posted Date
- 2020-10-27
- Lead Sponsor
- Takeda
- Registration Number
- NCT02760615
- Locations
- 🇺🇸
WCCT, Cypress, California, United States
🇺🇸QPS MRA, Miami, Florida, United States
N-of-1 Trials for Blood Pressure Medications in Adults
- Conditions
- Interventions
- First Posted Date
- 2016-04-20
- Last Posted Date
- 2019-03-26
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 10
- Registration Number
- NCT02744456
- Locations
- 🇺🇸
Columbia University Medical Center, New York, New York, United States
A Controlled Trial of Losartan in Posttraumatic Stress Disorder
- Conditions
- Interventions
- First Posted Date
- 2016-03-15
- Last Posted Date
- 2021-03-12
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 149
- Registration Number
- NCT02709018
- Locations
- 🇺🇸
George Washington University, Washington, District of Columbia, United States
🇺🇸McLean Hospital, Belmont, Massachusetts, United States
🇺🇸New York University Langone Health, New York, New York, United States
Resveratrol's Effects in Diabetic Nephropathy
- Conditions
- Interventions
- First Posted Date
- 2016-03-10
- Last Posted Date
- 2017-10-05
- Lead Sponsor
- Shiraz University of Medical Sciences
- Target Recruit Count
- 60
- Registration Number
- NCT02704494
- Locations
- 🇮🇷
Shahid Motahhari Clinic, Shiraz University of Medical Sciences, Shiraz, Fars, Iran, Islamic Republic of
Losartan Effects on Emphysema Progression
- First Posted Date
- 2016-03-02
- Last Posted Date
- 2022-06-01
- Lead Sponsor
- JHSPH Center for Clinical Trials
- Target Recruit Count
- 220
- Registration Number
- NCT02696564
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸University of Arizona, Tucson, Arizona, United States
🇺🇸University of Florida College of Medicine, Jacksonville, Florida, United States
The ENRGISE (ENabling Reduction of Low-Grade Inflammation in SEniors) Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2016-02-08
- Last Posted Date
- 2024-05-07
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 289
- Registration Number
- NCT02676466
- Locations
- 🇺🇸
Wake Forest University, Winston-Salem, North Carolina, United States
🇺🇸University of Florida, Gainesville, Florida, United States
🇺🇸Northwestern University, Chicago, Illinois, United States
Randomized Clinical Trial of Intravitreal Bevacizumab Versus Intravitreal Bevacizumab Combined With Losartan in the Treatment of Diabetic Macular Edema
- Conditions
- Interventions
- First Posted Date
- 2016-01-26
- Last Posted Date
- 2016-07-06
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 57
- Registration Number
- NCT02663141
- Locations
- 🇮🇷
Farabi Eye Hospital, Tehran, Iran, Islamic Republic of
Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
- First Posted Date
- 2015-09-25
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- Emory University
- Target Recruit Count
- 134
- Registration Number
- NCT02560805
- Locations
- 🇺🇸
Atlanta VA Medical Center, Decatur, Georgia, United States
Drug Development Updates
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