Disulfiram
- Generic Name
- Disulfiram
- Brand Names
- Antabuse
- Drug Type
- Small Molecule
- Chemical Formula
- C10H20N2S4
- CAS Number
- 97-77-8
- Unique Ingredient Identifier
- TR3MLJ1UAI
- Background
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nau...
- Indication
For the treatment and management of chronic alcoholism
- Associated Conditions
- Chronic Alcoholism
- Associated Therapies
- -
Disulfiram Plus Arsenic Trioxide In Patients With Metastatic Melanoma and at Least One Prior Systemic Therapy
- First Posted Date
- 2007-12-11
- Last Posted Date
- 2019-08-07
- Lead Sponsor
- University of California, Irvine
- Target Recruit Count
- 9
- Registration Number
- NCT00571116
- Locations
- ๐บ๐ธ
Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California, United States
Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence
- Conditions
- First Posted Date
- 2007-02-15
- Last Posted Date
- 2007-02-16
- Lead Sponsor
- Finnish Institute for Health and Welfare
- Target Recruit Count
- 243
- Registration Number
- NCT00435435
- Locations
- ๐ซ๐ฎ
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
Disulfiram for Cocaine Abuse
- First Posted Date
- 2006-11-03
- Last Posted Date
- 2013-11-13
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 118
- Registration Number
- NCT00395850
- Locations
- ๐บ๐ธ
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
CBT With Disulfiram and Contingency Management
- Conditions
- Interventions
- First Posted Date
- 2006-07-11
- Last Posted Date
- 2014-12-03
- Lead Sponsor
- Yale University
- Target Recruit Count
- 181
- Registration Number
- NCT00350870
- Locations
- ๐บ๐ธ
APT Foundation, New Haven, Connecticut, United States
Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
- Conditions
- Interventions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2012-01-31
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 158
- Registration Number
- NCT00218608
- Locations
- ๐บ๐ธ
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Pharmacogenetics of Disulfiram for Cocaine
- Conditions
- Interventions
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2017-03-15
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 93
- Registration Number
- NCT00149630
- Locations
- ๐บ๐ธ
Michael E. DeBakey VA Medical Center, Houston, Texas, United States
Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1
- Conditions
- Interventions
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 208
- Registration Number
- NCT00142844
- Locations
- ๐บ๐ธ
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Interactions Between Cocaine and Ethanol and Disulfiram - 1
- Conditions
- First Posted Date
- 2004-10-15
- Last Posted Date
- 2017-01-11
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 16
- Registration Number
- NCT00094289
- Locations
- ๐บ๐ธ
University of Texas Hlth Sci Ctr San Ant, San Antonio, Texas, United States
๐บ๐ธUCLA Integrated Substance Abuse Program, Los Angeles, California, United States
Depot Disulfiram for AIDS and ARC
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- St. Vincent's Medical Center
- Registration Number
- NCT00002065
- Locations
- ๐บ๐ธ
Saint Vincent's Med Ctr, Staten Island, New York, United States
Disulfiram for Cocaine-Alcohol Abuse - 3
- Conditions
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2020-06-18
- Lead Sponsor
- Yale University
- Registration Number
- NCT00000278
- Locations
- ๐บ๐ธ
VA Connecticut Healthcare System, New Haven, Connecticut, United States
Drug Development Updates
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