Vitamin C

Generic Name: Vitamin C

Brand Names: Ascor, Citranatal B-calm Kit, Concept Ob, Ferralet 90, Hematogen, Infuvite, Infuvite Pediatric, Moviprep, Mvc-fluoride, Mvi Pediatric, Natafort, Plenvu, Pregvit, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₆H_₈O_₆

CAS Number: 50-81-7

Unique Ingredient Identifier: PQ6CK8PD0R

Background: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Indication: Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

Associated Conditions: Common Cold, Deficiency, Vitamin A, Deficiency, Vitamin D, Fever, Flu caused by Influenza, Folate deficiency, Iron Deficiency (ID), Iron Deficiency Anemia (IDA), Oral bacterial infection, Scurvy, Vitamin C Deficiency, Vitamin Deficiency

Associated Therapies: Nutritional supplementation, Vitamin supplementation

Clinical Trials

Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Fractures

Phase 4

Recruiting

Conditions: Distal Radius Fracture
Prophylaxis
Vitamine c

Interventions: Drug: Vitamin C
Drug: Placebo

First Posted Date: 2023-05-06

Last Posted Date: 2024-05-02

Lead Sponsor: Damascus University

Target Recruit Count: 220

Registration Number: NCT05842395

Locations: 🇸🇾
Damascus University, Damascus, Syrian Arab Republic

Ascorbic Acid to Prevent Postreperfusion Syndrome in Liver Transplantation

Phase 2

Recruiting

Conditions: Liver Transplantation
Postreperfusion Syndrome
Ascorbic Acid

Interventions: Drug: Ascorbic acid
Drug: 0.9% Saline solution

First Posted Date: 2023-03-03

Last Posted Date: 2023-03-03

Lead Sponsor: Hospital Universitario Ramon y Cajal

Target Recruit Count: 70

Registration Number: NCT05754242

Locations: 🇪🇸
Hospital Universitario RAmon y Cajal, Madrid, Spain

Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism

Phase 2

Recruiting

Conditions: Hypothyroidism
Primary Hypothyroidism
Vitamin C Deficiency

Interventions: Drug: Oral Rehydration Salt Formulations
Drug: Vitamin C

First Posted Date: 2023-02-17

Last Posted Date: 2024-01-11

Lead Sponsor: Dr Adnan Agha

Target Recruit Count: 40

Registration Number: NCT05733078

Locations: 🇦🇪
Internal Medicine, College of Medicine and Health Sciences, Al Ain, Abu Dhabi, United Arab Emirates

Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients.

Phase 2

Recruiting

Conditions: Vitamin C
COVID-19 Pneumonia

Interventions: Drug: Vitamin C
Drug: Placebo

First Posted Date: 2023-01-23

Last Posted Date: 2023-01-23

Lead Sponsor: Zhujiang Hospital

Target Recruit Count: 608

Registration Number: NCT05694975

Locations: 🇨🇳
Yunfu People's Hospital, Yunfu, Guangdong, China
🇨🇳
Department of Critical Care Medicine of Zhongshan People's Hospital, Zhongshan, Guangzhou, China
🇨🇳
Department of Critical Care Medicine of Zhujiang Hospital, Guanzhou, Guangdong, China

and more 1 locations

Vitamin C as add-on Therapy in Patients With Acute Herpes Zoster

Phase 2

Terminated

Conditions: Neuropathic Pain

Interventions: Drug: Vitamin C

First Posted Date: 2022-09-30

Last Posted Date: 2024-11-07

Lead Sponsor: Pascoe Pharmazeutische Praeparate GmbH

Target Recruit Count: 12

Registration Number: NCT05561257

Locations: 🇩🇪
dermatologisches zentrum Bonn, Bonn, Hessen, Germany
🇩🇪
Universitätsklinikum Frankfurt am Main, Frankfurt am Main, Hessen, Germany
🇩🇪
Hautklinik der Universitätsmedizin Mainz KöR, Mainz, Hessen, Germany

Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Not Applicable

Conditions: Post Operative Pain

Interventions: Drug: Ascorbic acid
Other: saline

First Posted Date: 2022-07-28

Last Posted Date: 2022-08-01

Lead Sponsor: Cairo University

Target Recruit Count: 30

Registration Number: NCT05478044

The Effect of Vitamin C and E Therapy on Restless Leg Syndrome in Patients With End Stage Renal Disease on Haemodialysis

Phase 3

Conditions: Restless Legs Syndrome
End Stage Renal Disease

Interventions: Drug: Placebo capsule
Drug: Ascorbic acid
Drug: Tocopherol

First Posted Date: 2022-04-27

Last Posted Date: 2022-08-24

Lead Sponsor: King Abdulaziz University

Target Recruit Count: 160

Registration Number: NCT05350124

Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery

Phase 3

Recruiting

Conditions: Oxidative Stress
Ischemia-reperfusion Injury

Interventions: Drug: Intravenous Ascorbate
Drug: Normal Saline 10 mL Injection

First Posted Date: 2022-04-14

Last Posted Date: 2022-11-25

Lead Sponsor: University of Malaya

Target Recruit Count: 34

Registration Number: NCT05327348

Locations: 🇲🇾
Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
🇲🇾
Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
🇲🇾
University of Malaya Medical Centre, Kuala Lumpur, Malaysia

Immunonutrition for Diabetic Foot Ulcers

Phase 2

Terminated

Conditions: Diabetes Mellitus
Diabetic Peripheral Neuropathy
Diabetic Foot Ulcer

Interventions: Drug: Lovaza
Drug: L-Arginine Powder
Drug: Vitamin C

First Posted Date: 2022-03-16

Last Posted Date: 2024-12-27

Lead Sponsor: Prisma Health-Midlands

Target Recruit Count: 1

Registration Number: NCT05281562

Locations: 🇺🇸
Prisma Health, Columbia, South Carolina, United States

Clinical Efficacy of Megadose Vitamin C in Sepsis

Phase 2

Recruiting

Conditions: Septic Shock
Sepsis

Interventions: Drug: 5% glucose injection
Drug: Vitamin C

First Posted Date: 2022-01-18

Last Posted Date: 2024-03-19

Lead Sponsor: Zhujiang Hospital

Target Recruit Count: 234

Registration Number: NCT05194189

Locations: 🇨🇳
Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University, Guanzhou, Guangdong, China
🇨🇳
Department of Critical Care Medicine of Zhongshan People's Hospital, Zhongshan, Guangzhou, China
🇨🇳
Department of Critical Care Medicine of Yunfu People's Hospital, Yunfu, Guangdong, China

and more 1 locations

Drug Development Updates

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