Vitamin C

Generic Name: Vitamin C

Brand Names: Ascor, Citranatal B-calm Kit, Concept Ob, Ferralet 90, Hematogen, Infuvite, Infuvite Pediatric, Moviprep, Mvc-fluoride, Mvi Pediatric, Natafort, Plenvu, Pregvit, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₆H_₈O_₆

CAS Number: 50-81-7

Unique Ingredient Identifier: PQ6CK8PD0R

Background: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Indication: Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

Associated Conditions: Common Cold, Deficiency, Vitamin A, Deficiency, Vitamin D, Fever, Flu caused by Influenza, Folate deficiency, Iron Deficiency (ID), Iron Deficiency Anemia (IDA), Oral bacterial infection, Scurvy, Vitamin C Deficiency, Vitamin Deficiency

Associated Therapies: Nutritional supplementation, Vitamin supplementation

Clinical Trials

Treatment of Pulmonary Fibrosis Due to COVID-19 With Fuzheng Huayu

Phase 2

Completed

Conditions: Pulmonary Fibrosis Due to COVID-19

Interventions: Drug: Fuzheng Huayu Tablet
Drug: Vitamin C tablets
Drug: Placebo
Other: respiratory function rehabilitation training

First Posted Date: 2020-02-21

Last Posted Date: 2022-01-03

Lead Sponsor: ShuGuang Hospital

Target Recruit Count: 142

Registration Number: NCT04279197

Locations: 🇨🇳
Shuguang Hospital, Shanghai, Shanghai, China

Differences by Sex and Genotype in the Effects of Stress on Executive Functions

Phase 1

Recruiting

Conditions: Stress

Interventions: Drug: Methylphenidate
Drug: Vitamin C

First Posted Date: 2020-02-18

Last Posted Date: 2024-05-08

Lead Sponsor: University of British Columbia

Target Recruit Count: 146

Registration Number: NCT04273880

Locations: 🇨🇦
Developmental Cognitive Neuroscience Lab, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada

Trial of IV vs Oral Iron Treatment of Iron Deficiency Anemia in the Post-Operative Bariatric Surgical Patient

Phase 3

Recruiting

Conditions: Iron Deficiency Anemia

Interventions: Drug: Ferumoxytol
Drug: Saline
Drug: Ferrous sulfate tablets
Drug: Vitamin C

First Posted Date: 2020-02-13

Last Posted Date: 2023-06-12

Lead Sponsor: Auerbach Hematology Oncology Associates P C

Target Recruit Count: 104

Registration Number: NCT04268849

Locations: 🇺🇸
Auerbach Hematology and Oncology, Baltimore, Maryland, United States

Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia

Phase 2

Terminated

Conditions: Pneumonia, Ventilator-Associated
Vitamin C
Pneumonia, Viral

Interventions: Drug: Sterile Water for Injection
Drug: VC

First Posted Date: 2020-02-11

Last Posted Date: 2020-10-12

Lead Sponsor: ZhiYong Peng

Target Recruit Count: 56

Registration Number: NCT04264533

Locations: 🇨🇳
Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery

Phase 4

Conditions: Acute Kidney Injury

Interventions: Drug: Control (Normal saline)
Drug: Vitamin C

First Posted Date: 2019-12-24

Last Posted Date: 2020-03-26

Lead Sponsor: Yonsei University

Target Recruit Count: 264

Registration Number: NCT04210453

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research Institute, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis

Phase 3

Completed

Conditions: Sepsis
Septic Shock

Interventions: Drug: Vitamin C
Drug: Hydrocortisone
Drug: Complex B

First Posted Date: 2019-12-12

Last Posted Date: 2020-10-19

Lead Sponsor: IMSS Hospital General de Zona 11, Piedras Negras

Target Recruit Count: 19

Registration Number: NCT04197115

Locations: 🇲🇽
Hospital General Zona 11 Imss Piedras Negras Coahuila, Piedras Negras, Coahuila, Mexico

SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells

Phase 1

Recruiting

Conditions: BRCA1 Mutation
Pancreatic Acinar Cell Carcinoma
Breast Cancer Metastatic
BRCA2 Mutation
Pancreatic Cancer
Metastatic Pancreatic Ductal Adenocarcinoma
Breast Cancer Stage IV
Adenocarcinoma of the Breast
Pancreatic Ductal Adenocarcinoma
Metastatic Pancreatic Cancer

Interventions: Drug: Melphalan
Drug: BCNU
Drug: Vitamin B12B
Drug: Vitamin C
Drug: Ethanol
Device: Autologous Hematopoietic Stem Cells

First Posted Date: 2019-11-04

Last Posted Date: 2024-06-26

Lead Sponsor: General Oncology, Inc.

Target Recruit Count: 10

Registration Number: NCT04150042

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Memorial Sloan Kettering Cancer Center, New York, New York, United States

VItamin C in Thermal injuRY: The VICToRY Trial

Phase 3

Recruiting

Conditions: Thermal Burn
Shock

Interventions: Drug: placebo
Drug: Ascorbic Acid

First Posted Date: 2019-10-24

Last Posted Date: 2025-05-07

Lead Sponsor: Clinical Evaluation Research Unit at Kingston General Hospital

Target Recruit Count: 666

Registration Number: NCT04138394

Locations: 🇺🇸
Ascension Columbia St. Mary's, Milwaukee, Wisconsin, United States
🇧🇪
Grand Hopital de Charleroi, Charleroi, Hainaut, Belgium
🇧🇪
Ghent University Hospital, Ghent, Oost Vlaanderen, Belgium

and more 31 locations

Effect of Low Doses of Vitamin C on Salivary Cortisol , Heart Rate , Blood Pressure During Group Presentation

Phase 4

Completed

Conditions: Stress, Psychological

Interventions: Drug: ascorbic acid
Other: placebo

First Posted Date: 2019-10-22

Last Posted Date: 2019-10-22

Lead Sponsor: Kufa University

Target Recruit Count: 90

Registration Number: NCT04135378

Locations: 🇮🇶
Kufa University, Najaf, Kufa, Iraq

Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients

Phase 1

Active, not recruiting

Conditions: Bladder Cancer

Interventions: Drug: Ascorbic Acid

First Posted Date: 2019-08-06

Last Posted Date: 2025-03-25

Lead Sponsor: University of Kansas Medical Center

Target Recruit Count: 12

Registration Number: NCT04046094

Locations: 🇺🇸
The University of Kansas Cancer Center, Westwood Campus, Kansas City, Kansas, United States
🇺🇸
The University of Kansas Cancer Center (KUCC), Fairway, Kansas, United States
🇺🇸
The University of Kansas Medical Center, Kansas City, Kansas, United States

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