Vitamin C

Generic Name: Vitamin C

Brand Names: Ascor, Citranatal B-calm Kit, Concept Ob, Ferralet 90, Hematogen, Infuvite, Infuvite Pediatric, Moviprep, Mvc-fluoride, Mvi Pediatric, Natafort, Plenvu, Pregvit, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₆H_₈O_₆

CAS Number: 50-81-7

Unique Ingredient Identifier: PQ6CK8PD0R

Background: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Indication: Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

Associated Conditions: Common Cold, Deficiency, Vitamin A, Deficiency, Vitamin D, Fever, Flu caused by Influenza, Folate deficiency, Iron Deficiency (ID), Iron Deficiency Anemia (IDA), Oral bacterial infection, Scurvy, Vitamin C Deficiency, Vitamin Deficiency

Associated Therapies: Nutritional supplementation, Vitamin supplementation

Clinical Trials

Perioperative Vitamin C Lung Transplant

Phase 2

Withdrawn

Conditions: Primary Graft Dysfunction
Lung Transplant; Complications

Interventions: Drug: Vitamin C

First Posted Date: 2020-08-10

Last Posted Date: 2023-05-01

Lead Sponsor: University of Wisconsin, Madison

Registration Number: NCT04505878

Can Vitamin C Reduce the Risk of Postoperative Shoulder Stiffness?

Phase 4

Terminated

Conditions: Shoulder Stiffness

Interventions: Drug: Placebo
Drug: Vitamin C

First Posted Date: 2020-07-15

Last Posted Date: 2024-06-14

Lead Sponsor: Lindenhofgruppe AG

Target Recruit Count: 46

Registration Number: NCT04472000

Locations: 🇨🇭
Spital Aaberg, Aarberg, Bern, Switzerland
🇨🇭
Orthopädie Sonnenhof, Bern, Switzerland

The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19

Phase 4

Conditions: Covid-19

Interventions: Drug: Quercetin
Dietary Supplement: bromelain
Drug: Zinc
Drug: Vitamin C

First Posted Date: 2020-07-13

Last Posted Date: 2020-07-13

Lead Sponsor: Ministry of Health, Saudi Arabia

Target Recruit Count: 60

Registration Number: NCT04468139

Locations: 🇸🇦
Ministry of health.First health cluster ,Riaydh, Riyadh, Saudi Arabia

Vitamin C Versus Nitric Oxide in Prolonged Ventilation

Completed

Conditions: ARDS

Interventions: Drug: Vitamin C
Drug: Nitric Oxide
Device: ventilators

First Posted Date: 2020-06-02

Last Posted Date: 2020-06-09

Lead Sponsor: King Abdul Aziz Specialist Hospital

Target Recruit Count: 60

Registration Number: NCT04411160

Locations: 🇸🇦
King abd el Aziz specialist hospital, Ta'if, Saudi Arabia

Lessening Organ Dysfunction With VITamin C - COVID-19

Phase 3

Completed

Conditions: Vitamin C
COVID-19
Hospitalized Patients

Interventions: Drug: Control
Drug: Vitamin C

First Posted Date: 2020-05-26

Last Posted Date: 2023-04-21

Lead Sponsor: Université de Sherbrooke

Target Recruit Count: 392

Registration Number: NCT04401150

Locations: 🇨🇦
Research Centre of the CHUS, Sherbrooke, Quebec, Canada
🇨🇦
Research Center of the CHUS, Sherbrooke, Quebec, Canada

Pharmacologic Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment

Phase 2

Conditions: COVID-19

Interventions: Drug: Ascorbic Acid

First Posted Date: 2020-04-27

Last Posted Date: 2020-05-05

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 66

Registration Number: NCT04363216

Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation

Phase 1

Completed

Conditions: COVID-19
Hypoxia

Interventions: Drug: L-ascorbic acid

First Posted Date: 2020-04-22

Last Posted Date: 2022-02-25

Lead Sponsor: Hunter Holmes Mcguire Veteran Affairs Medical Center

Target Recruit Count: 20

Registration Number: NCT04357782

Locations: 🇺🇸
Hunter Holmes Mcguire Veteran Affairs Medical Center, Richmond, Virginia, United States

Treatment for COVID-19 in High-Risk Adult Outpatients

Phase 2

Terminated

Conditions: SARS-CoV-2
COVID-19

Interventions: Drug: Lopinavir 200 MG / Ritonavir 50 MG [Kaletra]
Drug: Ascorbic Acid
Drug: Hydroxychloroquine Sulfate
Drug: Folic Acid
Drug: Azithromycin

First Posted Date: 2020-04-21

Last Posted Date: 2022-08-08

Lead Sponsor: University of Washington

Target Recruit Count: 289

Registration Number: NCT04354428

Locations: 🇺🇸
SUNY Upstate Medical University, Syracuse, New York, United States
🇺🇸
Tulane University, New Orleans, Louisiana, United States
🇺🇸
University of Washington Coordinating Center, Seattle, Washington, United States

and more 3 locations

SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)

Phase 2

Completed

Conditions: COVID-19
Lung Injury, Acute
Kidney Injury

Interventions: Other: Placebo
Drug: L-ascorbic acid

First Posted Date: 2020-04-14

Last Posted Date: 2024-04-04

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 47

Registration Number: NCT04344184

Locations: 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP)

Phase 2

Completed

Conditions: SARS-CoV-2
SARS (Severe Acute Respiratory Syndrome)
COVID-19
Corona Virus Infection

Interventions: Drug: Ascorbic Acid
Drug: Hydroxychloroquine Sulfate

First Posted Date: 2020-04-01

Last Posted Date: 2021-12-16

Lead Sponsor: University of Washington

Target Recruit Count: 943

Registration Number: NCT04328961

Locations: 🇺🇸
University of Washington, Coordinating Center, Seattle, Washington, United States
🇺🇸
Tulane, New Orleans, Louisiana, United States
🇺🇸
University of California Los Angeles, Los Angeles, California, United States

and more 5 locations

Drug Development Updates

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