Articaine

Generic Name: Articaine

Brand Names: Articadent, Astracaine, Orabloc, Septanest, Septocaine, Ultacan, Ultracaine, Zorcaine

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₂₀N_₂O_₃S

CAS Number: 23964-58-1

Unique Ingredient Identifier: D3SQ406G9X

Background: Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

Indication: 适用于牙槽外科、牙髓治疗、牙体预备级黏膜切开等口腔手术麻醉。

Associated Therapies: Dental Local Anesthesia

Clinical Trials

An Open Label, Study of the Systemic Exposure to Articaine After Topical Ocular Dosing of AG-920

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: AG-920

First Posted Date: 2021-02-18

Last Posted Date: 2022-04-29

Lead Sponsor: American Genomics, LLC

Target Recruit Count: 14

Registration Number: NCT04759339

Locations: 🇺🇸
Celerion, Lincoln, Nebraska, United States

A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution

Phase 3

Completed

Conditions: Anesthesia, Local

Interventions: Drug: AG-920
Drug: Placebo

First Posted Date: 2020-08-14

Last Posted Date: 2022-09-28

Lead Sponsor: American Genomics, LLC

Target Recruit Count: 120

Registration Number: NCT04513652

Locations: 🇺🇸
American Genomics Site 1, Newport Beach, California, United States

Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth

Phase 4

Completed

Conditions: Overcoming the Failure of Anaesthesia
Maxillary Teeth
Dental Extraction

Interventions: Drug: Articaine 4%
Drug: Prilocain 3%
Drug: Adrenalin
Drug: Felypressin

First Posted Date: 2020-01-22

Last Posted Date: 2020-01-22

Lead Sponsor: Taibah University

Target Recruit Count: 95

Registration Number: NCT04236115

Locations: 🇸🇦
Taibah University, Medina, Saudi Arabia

A Comparison of 4% Articaine Versus 0.5%Bupivacaine for Ambulatory Surgery Under Supraclavicular Block

Phase 1

Completed

Conditions: Upper Limb Surgery
Hand Surgery

Interventions: Drug: Articaine
Drug: Bupivacaine

First Posted Date: 2019-12-06

Last Posted Date: 2020-04-28

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT04189198

Locations: 🇪🇬
Ain Shams University hosptal, Cairo, Abbasya, Egypt

The Effect of Buccal Infiltration Administration of Clonidine on the Success Rate of Inferior Alveolar Nerve Block

Phase 4

Withdrawn

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Clonidine
Drug: Articaine Hydrochloride + Epinephrine

First Posted Date: 2019-12-04

Last Posted Date: 2023-04-10

Lead Sponsor: University of California, San Francisco

Registration Number: NCT04186299

Articaine vs Dexmedetomidine Supplemented Articaine

Early Phase 1

Completed

Conditions: Renal Failure

Interventions: Drug: Articaine
Drug: Dexmedetomidine

First Posted Date: 2019-11-20

Last Posted Date: 2019-11-20

Lead Sponsor: Ain Shams University

Target Recruit Count: 50

Registration Number: NCT04171349

Locations: 🇪🇬
Ain Shams University hosptal, Cairo, Abbasya, Egypt

Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia

Phase 4

Completed

Conditions: Drug Effect
Tooth Extraction

Interventions: Drug: Articaine / EPINEPHrine Cartridge

First Posted Date: 2019-11-18

Last Posted Date: 2021-05-12

Lead Sponsor: Universidad de Antioquia

Target Recruit Count: 179

Registration Number: NCT04166890

Locations: 🇨🇴
University of Antioquia, Medellín, Antioquia, Colombia

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General

Phase 2

Withdrawn

Conditions: Caries,Dental
Apical Periodontitis

Interventions: Drug: Kovanaze Nasal Spray
Drug: Articaine Injection

First Posted Date: 2019-09-26

Last Posted Date: 2024-10-14

Lead Sponsor: Virginia Commonwealth University

Registration Number: NCT04104789

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics

Phase 2

Withdrawn

Conditions: Apical Periodontitis
Caries,Dental

Interventions: Drug: Articaine Injection
Drug: Kovanaze Nasal Spray

First Posted Date: 2019-09-26

Last Posted Date: 2020-06-25

Lead Sponsor: Virginia Commonwealth University

Registration Number: NCT04105985

Articaine Efficacy and Safety for Children Below Age of 4-years

Phase 1

Completed

Conditions: Behaviour Assessment
Pain

First Posted Date: 2019-08-19

Last Posted Date: 2020-02-17

Lead Sponsor: Minia University

Target Recruit Count: 184

Registration Number: NCT04061265

Locations: 🇪🇬
Ngwa Khattab, Minya, Minia, Egypt

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