Amoxicillin
- Generic Name
- Amoxicillin
- Brand Names
- Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500
- Drug Type
- Small Molecule
- Chemical Formula
- C16H19N3O5S
- CAS Number
- 26787-78-0
- Unique Ingredient Identifier
- 9EM05410Q9
- Background
Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.
Amoxicillin was granted FDA approval on 18 January 1974.
- Indication
Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.
Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.
- Associated Conditions
- Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections
Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori
- Conditions
- Functional DyspepsiaPeptic UlcerHelicobacter Pylori
- Interventions
- Other: long duration (14 day)
- First Posted Date
- 2012-08-17
- Last Posted Date
- 2013-06-04
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 180
- Registration Number
- NCT01667575
- Locations
- 🇨🇳
Renji Hospital, Shanghai, Shanghai, China
Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water
- Conditions
- Gastrointestinal Motility Disorder
- Interventions
- First Posted Date
- 2012-07-09
- Last Posted Date
- 2012-07-09
- Lead Sponsor
- University Medicine Greifswald
- Target Recruit Count
- 12
- Registration Number
- NCT01635608
- Locations
- 🇩🇪
Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Meckleburg-Vorpommern, Germany
The Effect of Routine Antibiotic Use in the Outpatient Treatment of Severely Malnourished Children Without Complications
- Conditions
- Severe Acute Malnutrition
- Interventions
- Drug: Placebo
- First Posted Date
- 2012-06-07
- Last Posted Date
- 2014-05-21
- Lead Sponsor
- Epicentre
- Target Recruit Count
- 2412
- Registration Number
- NCT01613547
- Locations
- 🇳🇪
Centres de Récupération et d'Education Nutritionnelle Ambulatoires de Dan Issa, Madarounfa, and Gabi, Maradi, Niger
Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients
- Conditions
- Helicobacter Pylori Infection
- Interventions
- Dietary Supplement: Lactobacillus reuteriDietary Supplement: Placebo
- First Posted Date
- 2012-05-08
- Last Posted Date
- 2015-08-17
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 70
- Registration Number
- NCT01593592
- Locations
- 🇪🇬
Zagazig University Hospitals, Zagazig, Sharkia, Egypt
Duration of Postoperative Antibiotic Prophylaxis in Facial Fractures
- Conditions
- Surgical Wound Infection
- Interventions
- Drug: Amoxicillin/clavulanic acid
- First Posted Date
- 2012-04-23
- Last Posted Date
- 2013-07-15
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 217
- Registration Number
- NCT01583062
- Locations
- 🇨🇭
Dep. of Oral and Maxillofacial Surgery, Bern University Hospital, Bern, Switzerland
Gut Flora and Lipid Metabolism
- Conditions
- Hypercholesterolemia
- Interventions
- Drug: Placebo capsule
- First Posted Date
- 2012-03-29
- Last Posted Date
- 2013-05-14
- Lead Sponsor
- Maastricht University Medical Center
- Target Recruit Count
- 77
- Registration Number
- NCT01566266
- Locations
- 🇳🇱
Maastricht University Medical Center, Maastricht, Limburg, Netherlands
Community Based Management of Fast Breathing in Infants Aged < 60 Days in Low-income Settlements of Karachi
- Conditions
- Fast Breathing in Young Infants
- Interventions
- Drug: Sugar Syrup
- First Posted Date
- 2012-02-15
- Last Posted Date
- 2014-06-03
- Lead Sponsor
- Aga Khan University
- Target Recruit Count
- 963
- Registration Number
- NCT01533818
- Locations
- 🇵🇰
Primary Health Centers, Karachi, Sind, Pakistan
Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)
- Conditions
- Community Acquired PneumoniaInfections
- Interventions
- First Posted Date
- 2012-02-10
- Last Posted Date
- 2015-01-13
- Lead Sponsor
- Forest Laboratories
- Target Recruit Count
- 161
- Registration Number
- NCT01530763
- Locations
- 🇺🇦
Investigational Site, Zaporizhia, Ukraine
🇬🇪Investigational Site2, Tbilisi, Georgia
🇬🇪Investigational Site3, Tbilisi, Georgia
The Effect of Amoxicillin Versus Placebo on Gastrointestinal Motility in Children
- Conditions
- Functional Gastrointestinal Disorders
- Interventions
- Other: Placebo
- First Posted Date
- 2012-02-09
- Last Posted Date
- 2022-09-22
- Lead Sponsor
- Nationwide Children's Hospital
- Target Recruit Count
- 33
- Registration Number
- NCT01530009
- Locations
- 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures
- Conditions
- Acute AppendicitisPerforated Gastroduodenal UlcerSmall Bowel Obstruction
- Interventions
- First Posted Date
- 2012-02-01
- Last Posted Date
- 2012-02-08
- Lead Sponsor
- The Faculty Hospital Na Bulovce
- Target Recruit Count
- 187
- Registration Number
- NCT01524081
- Locations
- 🇨🇿
Faculty Hospital Bulovka, Prague, Czech Republic
Drug Development Updates
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