Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Clinical Trials

Efficacy Study for Standard Versus Double Dose of Amoxicillin in WHO Defined Non-severe Pneumonia

Phase 1

Completed

Conditions: Pneumonia

First Posted Date: 2011-06-17

Last Posted Date: 2011-06-17

Lead Sponsor: ARI Research Cell

Target Recruit Count: 900

Registration Number: NCT01375426

Locations: 🇵🇰
ARI Research Cell, Children Hospital, Pakistan Institute of Medical Sciences, Islamabad, Capital, Pakistan

Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice

Phase 4

Completed

Conditions: Erythema Migrans
Lyme Disease
Erythema Chronicum Migrans
Early Lyme Disease
Borreliosis

Interventions: Drug: Phenoxymethylpenicillin
Drug: Amoxicillin
Drug: Doxycycline

First Posted Date: 2011-06-07

Last Posted Date: 2014-12-12

Lead Sponsor: Morten Lindbaek

Target Recruit Count: 225

Registration Number: NCT01368341

Locations: 🇳🇴
Antibiotic Centre for Primary Care, University of Oslo, Oslo, Norway

Once-daily Therapy for Streptococcal Pharyngitis

Phase 1

Completed

Conditions: Streptococcal Sore Throat

Interventions: Drug: Intramuscular Benzathin Penicillin G
Drug: Amoxicillin

First Posted Date: 2011-03-08

Last Posted Date: 2011-03-08

Lead Sponsor: Azad University of Medical Sciences

Registration Number: NCT01310361

Locations: 🇮🇷
Islamic Azad University, Mashhad, Khorasan, Iran, Islamic Republic of

Antibiotic Efficacy in Pneumonitis Following Paraffin (Kerosene) Ingestion in Children

Not Applicable

Completed

Conditions: Kerosene Pneumonitis

Interventions: Drug: Amoxicillin
Drug: Placebo

First Posted Date: 2010-12-06

Last Posted Date: 2015-11-09

Lead Sponsor: University of Cape Town

Target Recruit Count: 74

Registration Number: NCT01253980

Locations: 🇿🇦
Red Cross War Memorial Children's Hospital, Cape Town, Western Cape, South Africa

Clinical Efficacy of Amoxicillin Given Twice or Three Times a Day Among Children With Non-severe Pneumonia

Phase 4

Completed

Conditions: Community-acquired Pneumonia

Interventions: Drug: Amoxicillin

First Posted Date: 2010-09-14

Last Posted Date: 2011-07-20

Lead Sponsor: Federal University of Bahia

Target Recruit Count: 820

Registration Number: NCT01200706

Locations: 🇧🇷
Professor Hosannah de Oliveira Pediatric Center, Salvador, Bahia, Brazil

Community Case Management of the Severe Pneumonia With Oral Amoxicillin in Children 2-59 Months of Age

Not Applicable

Completed

Conditions: Severe Pneumonia

Interventions: Other: Referral to Health facility
Drug: Amoxicillin

First Posted Date: 2010-09-01

Last Posted Date: 2017-05-22

Lead Sponsor: Aga Khan University

Target Recruit Count: 4070

Registration Number: NCT01192789

Locations: 🇵🇰
Aga Khan University Research Office, Matiari, Matiari, Sidh, Pakistan

Treatment of Group A Beta Hemolytic Streptococcal Pharyngitis in Children in Low Resource Settings

Not Applicable

Completed

Conditions: Streptococcal Infections
Pharyngitis

Interventions: Drug: Penicillin G, Benzathine
Drug: Amoxicillin

First Posted Date: 2010-07-05

Last Posted Date: 2010-07-05

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 558

Registration Number: NCT01156740

Locations: 🇭🇷
University Hospital for Infectious Diseases, Zagreb, Croatia
🇧🇷
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
🇪🇬
Cairo University, Cairo, Egypt