Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Suprainguinal Fascia Iliaca (SIFI) Block Improves Analgesia Following Total Hip Arthroplasty

Phase 4

Terminated

Conditions: Hip Osteoarthritis
Pain
Primary Total Hip Arthroplasty

Interventions: Procedure: Sham block
Procedure: Suprainguinal fascia iliaca (SIFI) block
Drug: Saline
Drug: Ropivacaine

First Posted Date: 2016-10-14

Last Posted Date: 2022-07-19

Lead Sponsor: Duke University

Target Recruit Count: 11

Registration Number: NCT02933671

Locations: 🇺🇸
Duke University Hospital, Durham, North Carolina, United States

Comparing Ropivacaine and Bupivacaine in DTFNB Anesthesia in Patients Undergoing Phacoemulsification

Not Applicable

Completed

Conditions: Cataract Unilateral Pending Extraction
Anesthesia

Interventions: Procedure: Deep Topical Fornix Nerve block anesthesia
Drug: Bupivacaine
Drug: Ropivacaine
Drug: Proparacaine

First Posted Date: 2016-10-06

Last Posted Date: 2017-01-25

Lead Sponsor: Government Medical College, Haldwani

Target Recruit Count: 100

Registration Number: NCT02925832

Locations: 🇮🇳
Government medical college, Haldwani, Uttarakhand, India

Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients

Not Applicable

Completed

Conditions: Neuroblastoma

Interventions: Drug: ropivacaine
Device: propofol
Behavioral: Wong-Baker FACES® Pain Rating Scale
Behavioral: Post-procedural quality of life (QOL)

First Posted Date: 2016-10-05

Last Posted Date: 2022-11-08

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 56

Registration Number: NCT02924324

Locations: 🇺🇸
Memorial Sloan Kettering Cancer Center, New York, New York, United States

Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section

Phase 3

Terminated

Conditions: Unplanned Caesarean Section

Interventions: Drug: Chloroprocaine
Drug: Ropivacaine

First Posted Date: 2016-09-29

Last Posted Date: 2023-11-21

Lead Sponsor: Sintetica SA

Target Recruit Count: 16

Registration Number: NCT02919072

Locations: 🇧🇪
UZ Leuven, campus Gasthuisberg, Leuven, Belgium

Continous Quadratus Lumborum Block for Hepatic Surgery With Right Subcostal Incision

Not Applicable

Terminated

Conditions: Hepatectomy
Analgesia
Nerve Block

Interventions: Procedure: Continous QLB (quadratus lumborum block)
Drug: Morphine given as IPCA
Device: Philip CX50 Ultrasound Scanner
Drug: Ropivacaine

First Posted Date: 2016-09-26

Last Posted Date: 2019-09-04

Lead Sponsor: Cui Xulei

Target Recruit Count: 40

Registration Number: NCT02914015

Locations: 🇨🇳
Xulei CUI, Beijing, Beijing, China

The Effect of Phrenic Nerve Block on Postoperative Shoulder Pain in Patients for Liver Resection.

Phase 4

Conditions: Shoulder Pain
Surgery
Nerve Block

Interventions: Drug: Ropivacaine

First Posted Date: 2016-09-16

Last Posted Date: 2016-09-23

Lead Sponsor: Eske Kvanner Aasvang

Target Recruit Count: 30

Registration Number: NCT02903719

Locations: 🇩🇰
Rigshospitalet, Copenhagen, Denmark

Ropivacaine Transversus Abdominis Plane Blocks for Cesarean Section Analgesia

Not Applicable

Terminated

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine

First Posted Date: 2016-09-08

Last Posted Date: 2022-09-21

Lead Sponsor: Maimonides Medical Center

Target Recruit Count: 51

Registration Number: NCT02893423

Locations: 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States

Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia

Not Applicable

Conditions: Labor Analgesia

Interventions: Procedure: Epidural analgesia
Procedure: Continuous epidural infusion
Procedure: Intermittent epidural bolus
Drug: ropivacaine
Drug: sufentanil

First Posted Date: 2016-08-19

Last Posted Date: 2016-12-28

Lead Sponsor: Nanjing Maternity and Child Health Care Hospital

Target Recruit Count: 186

Registration Number: NCT02873091

Locations: 🇨🇳
Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China

Ultrasound-guided Thoracic Paravertebral Block Using Ropivacaine With/Without Dexamethasone in Elective Thoracotomy

Not Applicable

Completed

Conditions: Surgery

Interventions: Drug: Ropivacaine
Other: saline
Drug: Dexamethasone

First Posted Date: 2016-08-18

Last Posted Date: 2017-02-09

Lead Sponsor: The First Affiliated Hospital of Anhui Medical University

Target Recruit Count: 68

Registration Number: NCT02871193

Locations: 🇨🇳
The first affiliated hospital of Anhui Medical University, Hefei, Anhui, China

Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Knee Osteoarthritis

Interventions: Drug: liposomal bupivacaine
Drug: bupivacaine HCl
Drug: Ropivacaine
Drug: Saline

First Posted Date: 2016-08-11

Last Posted Date: 2020-10-08

Lead Sponsor: Texas Orthopaedics, Sports and Rehabilitation Associates

Target Recruit Count: 63

Registration Number: NCT02863120

Locations: 🇺🇸
Texas Orthopedics, Austin, Texas, United States

Drug Development Updates

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