Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

A Safety and Effectiveness Pilot Study of PRF-108 and PRF-110 in Healthy Volunteers

Phase 1

Completed

Conditions: Pain

Interventions: Drug: Ropivacaine
Drug: PRF-110
Drug: PRF-108
Drug: Placebo

First Posted Date: 2009-04-17

Last Posted Date: 2020-11-16

Lead Sponsor: PainReform LTD

Target Recruit Count: 15

Registration Number: NCT00883194

Locations: 🇮🇱
Hadassah University Hospital, Jerusalem, Israel

Ultrasound Guided Supraclavicular Nerve Block

Phase 3

Completed

Conditions: Local Anesthetic

Interventions: Drug: Ropivacaine
Drug: Mepivacaine

First Posted Date: 2009-01-21

Last Posted Date: 2017-06-14

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 103

Registration Number: NCT00825786

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Efficacy of Ropivacaine Continuous Wound Instillation Versus Single Shot After Spine Fusion Surgery

Phase 4

Terminated

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine

First Posted Date: 2009-01-15

Last Posted Date: 2022-11-29

Lead Sponsor: Centre Hospitalier Universitaire de Nice

Target Recruit Count: 60

Registration Number: NCT00823576

Locations: 🇫🇷
CHU de Nice - 4 avenue Reine Victoria - Hôpital de Cimiez, Nice, Alpes-Maritimes, France

Postoperative Analgesia With Local Infiltration After Periacetabular Osteotomy

Phase 4

Completed

Conditions: Periacetabular Osteotomy
Pain

Interventions: Drug: Ropivacaine
Drug: Placebo

First Posted Date: 2008-12-30

Last Posted Date: 2011-03-16

Lead Sponsor: Odense University Hospital

Target Recruit Count: 70

Registration Number: NCT00815503

Locations: 🇩🇰
Odense University Hospital, Odense, Denmark

The Effect of Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine or Bupivacaine

Not Applicable

Terminated

Conditions: Anesthesia, Local
Shoulder Surgery

Interventions: Drug: saline
Drug: Dexamethasone
Drug: ropivacaine
Drug: Bupivacaine

First Posted Date: 2008-12-03

Last Posted Date: 2017-05-01

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 218

Registration Number: NCT00801138

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study

Phase 4

Completed

Conditions: Vaginal Prolapse

Interventions: Drug: Ropivacaine
Drug: Isotonic NaCl

First Posted Date: 2008-10-08

Last Posted Date: 2010-07-09

Lead Sponsor: Hvidovre University Hospital

Target Recruit Count: 48

Registration Number: NCT00769054

Locations: 🇩🇰
Hvidovre University Hospital, Copenhagen, Hvidovre, Denmark

Ultrasound-Guided Axillary or Infraclavicular Nerve Block for Upper Limb Surgery

Phase 4

Completed

Conditions: Upper Extremity
Orthopedic Surgery
Trauma
Forearm Injuries
Nerve Block

Interventions: Drug: Midazolam
Drug: Ropivacaine
Drug: Fentanyl
Procedure: General anesthesia
Procedure: Infraclavicular brachial plexus block
Procedure: Axillary brachial plexus nerve block

First Posted Date: 2008-07-29

Last Posted Date: 2009-07-15

Lead Sponsor: University of Parma

Target Recruit Count: 52

Registration Number: NCT00724035

Locations: 🇮🇹
University Hospital / Azienda Ospedaliero-Universitaria, Parma, PR, Italy

Intraperitoneal Local Anaesthetic in Colonic Surgery

Phase 1

Completed

Conditions: Colon Surgery

Interventions: Drug: 0.9% Saline
Drug: Ropivacaine

First Posted Date: 2008-07-25

Last Posted Date: 2010-01-13

Lead Sponsor: University of Auckland, New Zealand

Target Recruit Count: 60

Registration Number: NCT00722709

Locations: 🇳🇿
University of Auckland, Auckland, New Zealand
🇳🇿
Manukau Surgery Centre-Middlemore Hospital, Auckland, New Zealand

Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain

Not Applicable

Terminated

Conditions: Pain
Nausea

Interventions: Drug: Lidocaine/Ketamine
Other: placebo
Drug: ropivacaine

First Posted Date: 2008-07-22

Last Posted Date: 2019-03-12

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 12

Registration Number: NCT00720330

Locations: 🇺🇸
Cleveland Clinic/Hillcrest Hospital, Mayfield Heights, Ohio, United States

Ultrasound Guidance for Interscalene Brachial Plexus Block

Phase 4

Completed

Conditions: Shoulder
Orthopedic Surgery
Nerve Block

Interventions: Procedure: Ultrasound-guided continuous interscalene brachial plexus block
Procedure: Continuous interscalene brachial plexus block using electrical nerve stimulation
Drug: Ropivacaine
Drug: Paracetamol
Drug: Morphine
Drug: Fentanyl
Procedure: General anesthesia

First Posted Date: 2008-06-20

Last Posted Date: 2009-11-16

Lead Sponsor: University of Parma

Target Recruit Count: 50

Registration Number: NCT00702416

Locations: 🇮🇹
University Hospital / Azienda Ospedaliero-Universitaria, Parma, PR, Italy

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