Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol

Phase 4

Completed

Conditions: Femoral Neck Fracture

Interventions: Drug: ropivacaine

First Posted Date: 2010-01-21

Last Posted Date: 2017-11-01

Lead Sponsor: University Hospital, Angers

Target Recruit Count: 60

Registration Number: NCT01052974

Locations: 🇫🇷
UHAngers, Angers, France

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Not Applicable

Completed

Conditions: Osteoarthritis,Knee

Interventions: Drug: Ropivacaine
Drug: Toradol
Drug: Clonidine
Drug: Epinephrine

First Posted Date: 2010-01-05

Last Posted Date: 2013-11-08

Lead Sponsor: Towson Orthopaedic Associates

Target Recruit Count: 160

Registration Number: NCT01042093

Effect of Local Infiltration Analgesia in Total Hip Arthroplasty

Phase 4

Completed

Conditions: Post-operative Pain

Interventions: Drug: Ropivacaine

First Posted Date: 2009-08-31

Last Posted Date: 2011-09-29

Lead Sponsor: Hvidovre University Hospital

Target Recruit Count: 120

Registration Number: NCT00968955

Locations: 🇩🇰
Hvidovre University Hospital, Copenhagen, Hvidover, Denmark
🇩🇰
Hørsholm Hospital, Hørsholm, Denmark

Postoperative Pain in Children With Cerebral Palsy After Pelvic and Femoral Osteotomies

Phase 4

Completed

Conditions: Postoperative Pain
Cerebral Palsy

Interventions: Drug: Saline
Drug: Ropivacaine

First Posted Date: 2009-08-25

Last Posted Date: 2013-01-28

Lead Sponsor: University of Aarhus

Target Recruit Count: 12

Registration Number: NCT00964639

Locations: 🇩🇰
Departement of childrens orthopaedics, Aarhus University Hospital, Aarhus, Denmark

Femoral Block With or Without Ropivacaine for Analgesia After Total Knee Replacement (TKR)

Phase 1

Completed

Conditions: Total Knee Replacement

Interventions: Drug: Ropivacaine

First Posted Date: 2009-05-29

Last Posted Date: 2011-02-28

Lead Sponsor: Hopital de l'Enfant-Jesus

Target Recruit Count: 80

Registration Number: NCT00910013

Locations: 🇨🇦
CHA-Pavillon Enfant-Jésus, Québec, Quebec, Canada

Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Osteoarthritis, Knee

Interventions: Drug: ropivacaine
Drug: morphine sulfate
Drug: ketorolac
Drug: epinephrine
Drug: cefuroxime

First Posted Date: 2009-05-14

Last Posted Date: 2013-01-25

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 101

Registration Number: NCT00901628

Locations: 🇰🇷
Joint Reconstruction Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Local Infiltration Analgesia With Ropivacaine Versus Placebo in Caesarean Section

Phase 4

Completed

Conditions: Pain, Postoperative
Postoperative Nausea and Vomiting
Cesarean Section

Interventions: Drug: placebo
Drug: Ropivacaine

First Posted Date: 2009-05-01

Last Posted Date: 2011-06-23

Lead Sponsor: Hvidovre University Hospital

Target Recruit Count: 90

Registration Number: NCT00891540

Locations: 🇩🇰
Hvidovre University Hospital, Copenhagen, Hvidovre, Denmark

A Safety and Effectiveness Pilot Study of PRF-108 and PRF-110 in Healthy Volunteers

Phase 1

Completed

Conditions: Pain

Interventions: Drug: Ropivacaine
Drug: PRF-110
Drug: PRF-108
Drug: Placebo

First Posted Date: 2009-04-17

Last Posted Date: 2020-11-16

Lead Sponsor: PainReform LTD

Target Recruit Count: 15

Registration Number: NCT00883194

Locations: 🇮🇱
Hadassah University Hospital, Jerusalem, Israel

Ultrasound Guided Supraclavicular Nerve Block

Phase 3

Completed

Conditions: Local Anesthetic

Interventions: Drug: Ropivacaine
Drug: Mepivacaine

First Posted Date: 2009-01-21

Last Posted Date: 2017-06-14

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 103

Registration Number: NCT00825786

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Efficacy of Ropivacaine Continuous Wound Instillation Versus Single Shot After Spine Fusion Surgery

Phase 4

Terminated

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine

First Posted Date: 2009-01-15

Last Posted Date: 2022-11-29

Lead Sponsor: Centre Hospitalier Universitaire de Nice

Target Recruit Count: 60

Registration Number: NCT00823576

Locations: 🇫🇷
CHU de Nice - 4 avenue Reine Victoria - Hôpital de Cimiez, Nice, Alpes-Maritimes, France

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