Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population

Phase 4

Completed

Conditions: Anesthesia, Local

Interventions: Drug: Ropivacaine

First Posted Date: 2020-03-06

Last Posted Date: 2024-05-17

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 4

Registration Number: NCT04298099

Locations: 🇺🇸
Texas Children's Hospital, Houston, Texas, United States

Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery

Phase 4

Withdrawn

Conditions: Acute Pain
Anesthesia, Conduction
Arthroplasty, Replacement, Knee

Interventions: Procedure: adductor canal block
Drug: Ropivacaine
Procedure: SPANK

First Posted Date: 2020-03-02

Last Posted Date: 2020-11-24

Lead Sponsor: Bruce Ben-David

Registration Number: NCT04290442

Locations: 🇺🇸
UPMC Shadyside Hospital, Pittsburgh, Pennsylvania, United States

Regional Anesthesia in Total Hip and Knee Arthroplasty

Phase 4

Conditions: Knee Osteoarthritis
Hip Osteoarthritis

Interventions: Drug: Bupivacaine
Drug: Ropivacaine
Drug: Mepivacaine

First Posted Date: 2020-02-06

Last Posted Date: 2022-08-08

Lead Sponsor: Ottawa Hospital Research Institute

Target Recruit Count: 135

Registration Number: NCT04257682

Trial Evaluating the Efficacy of the Combination of ROpivacaine With Reference XYlocaine in the Evaluation of Pain During the Installation of Percutaneous Radiological GASTrostomy

Phase 2

Terminated

Conditions: Feeding Disorders
Cancer

Interventions: Drug: Lidocaine
Drug: Ropivacaine

First Posted Date: 2020-01-31

Last Posted Date: 2024-01-31

Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Target Recruit Count: 17

Registration Number: NCT04250805

Locations: 🇫🇷
CHU de Saint-Etienne, Saint-Priest-en-Jarez, France
🇫🇷
Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez, France

The MEC90 of Epidural Ropivacaine Blunting Hemodynamic Changes to Pneumoperitoneum

Not Applicable

Conditions: Laparoscopic Gastrectomy

Interventions: Drug: Ropivacaine

First Posted Date: 2020-01-30

Last Posted Date: 2020-01-30

Lead Sponsor: Keimyung University Dongsan Medical Center

Target Recruit Count: 50

Registration Number: NCT04247373

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Recruiting

Conditions: Rotator Cuff Tears
Rotator Cuff Injuries
Shoulder Arthritis
Shoulder Disease
Shoulder Pain
Rotator Cuff Arthropathy of Left Shoulder
Rotator Cuff Arthropathy of Right Shoulder
Shoulder Surgery
Shoulder Injuries
Rotator Cuff Repair

Interventions: Diagnostic Test: Ultrasound
Drug: Ropivacaine
Drug: Bupivacaine
Device: MediPines AGM100 Advanced Respiratory Monitoring System

First Posted Date: 2019-12-24

Last Posted Date: 2024-01-29

Lead Sponsor: Duke University

Target Recruit Count: 60

Registration Number: NCT04209504

Locations: 🇺🇸
Duke University Hospital, Durham, North Carolina, United States

High Versus Low Adductor Canal Block

Phase 4

Conditions: Osteo Arthritis Knee

Interventions: Drug: Ropivacaine

First Posted Date: 2019-11-07

Last Posted Date: 2020-10-30

Lead Sponsor: Carilion Clinic

Target Recruit Count: 140

Registration Number: NCT04155983

Locations: 🇺🇸
Carilion Institute for Orthopaedics & Neurosciences, Roanoke, Virginia, United States

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Phase 4

Conditions: Pain
Supratentorial Brain Tumor

Interventions: Drug: Ketorolac
Drug: Ropivacaine
Drug: Epinephrine

First Posted Date: 2019-10-28

Last Posted Date: 2020-01-22

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 100

Registration Number: NCT04141319

Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery

Not Applicable

Withdrawn

Conditions: Endometriosis
Pelvic Pain
Pelvic Prolapse

Interventions: Drug: Ropivacaine

First Posted Date: 2019-10-08

Last Posted Date: 2021-07-20

Lead Sponsor: University of Tennessee, Chattanooga

Registration Number: NCT04118777

The IPLA-OVCA Trial, Intra-Peritoneal Local Anaesthetics in Ovarian Cancer

Phase 3

Active, not recruiting

Conditions: Advanced Ovarian Cancer

Interventions: Drug: Saline Solution
Drug: Ropivacaine

First Posted Date: 2019-08-22

Last Posted Date: 2024-01-11

Lead Sponsor: Karolinska Institutet

Target Recruit Count: 220

Registration Number: NCT04065009

Locations: 🇸🇪
Karolinska Hospital, Solna, Stockholm, Sweden

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