Levothyroxine

Generic Name: Levothyroxine

Brand Names: Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₁₁I_₄NO_₄

CAS Number: 51-48-9

Unique Ingredient Identifier: Q51BO43MG4

Background: Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...

Indication: Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

Associated Conditions: Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer

Associated Therapies: -

Clinical Trials

Sorafenib Drug Drug Interaction Study in Healthy Male Subjects

Phase 1

Completed

Conditions: Drug Interactions

Interventions: Drug: Sorafenib (Nexavar, BAY43-9006)
Drug: Levothyroxine

First Posted Date: 2015-01-06

Last Posted Date: 2015-10-12

Lead Sponsor: Bayer

Target Recruit Count: 25

Registration Number: NCT02332031

The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance

Phase 4

Withdrawn

Conditions: Goiter

Interventions: Drug: Levothyroxine

First Posted Date: 2014-12-31

Last Posted Date: 2019-08-21

Lead Sponsor: Sheng-Chiang Su

Registration Number: NCT02329379

Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism

Not Applicable

Conditions: Hypothyroidism

Interventions: Drug: Levothyroxine Plus Liothyronine
Drug: Desiccated Thyroid Extract
Drug: Levothyroxine

First Posted Date: 2014-12-17

Last Posted Date: 2015-05-06

Lead Sponsor: Walter Reed National Military Medical Center

Target Recruit Count: 81

Registration Number: NCT02317926

Locations: 🇺🇸
Walter Reed National Military Medical Center, Besthesda, Maryland, United States

Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial

Phase 4

Terminated

Conditions: Brain Dead Organ Donors

Interventions: Drug: Levothyroxine
Drug: placebo

First Posted Date: 2014-08-07

Last Posted Date: 2018-07-17

Lead Sponsor: Hopital du Sacre-Coeur de Montreal

Target Recruit Count: 15

Registration Number: NCT02211053

Locations: 🇨🇦
Hopital du Sacré-Coeur de Montreal, Montreal, Quebec, Canada

Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism

Phase 4

Withdrawn

Conditions: Subclinical hypothyroïdism

Interventions: Drug: LEVOTHYROXINE

First Posted Date: 2014-07-10

Last Posted Date: 2016-10-28

Lead Sponsor: Centre Hospitalier Universitaire de Nice

Registration Number: NCT02186405

Locations: 🇫🇷
Nephrology Department, Nice, France

Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism

Phase 2

Completed

Conditions: Subclinical Hypothyroidism

Interventions: Drug: Levothyroxine
Drug: Placebo

First Posted Date: 2014-03-18

Last Posted Date: 2014-03-18

Lead Sponsor: Isfahan University of Medical Sciences

Target Recruit Count: 50

Registration Number: NCT02090907

Locations: 🇮🇷
Khorshid endocrinology clinic, Isfahan, Iran, Islamic Republic of

Early Levothyroxine Post Radioactive Iodine

Phase 2

Completed

Conditions: Graves' Disease

Interventions: Other: Placebo
Drug: Levothyroxine

First Posted Date: 2013-09-25

Last Posted Date: 2019-10-29

Lead Sponsor: Mayo Clinic

Target Recruit Count: 61

Registration Number: NCT01950260

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

The TRUST Study - Depression Substudy

Phase 4

Completed

Conditions: Depression
Subclinical Hypothyroidism

Interventions: Drug: Placebo
Drug: Levothyroxine

First Posted Date: 2013-05-15

Last Posted Date: 2018-06-14

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 426

Registration Number: NCT01853579

Locations: 🇳🇱
Leiden University Medical Center, Leiden, Netherlands
🇨🇭
Department of General Internal Medicine, Lausanne, Vaud, Switzerland
🇨🇭
University Clinic for General Internal Medicine, Bern University Hospital, Bern, Switzerland

Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism

Phase 4

Conditions: Hypothyroidism
Thyroid Diseases
Endocrine System Diseases

Interventions: Drug: L-thyroxine

First Posted Date: 2013-05-07

Last Posted Date: 2023-01-18

Lead Sponsor: Shandong Provincial Hospital

Target Recruit Count: 700

Registration Number: NCT01848171

Locations: 🇨🇳
Shandong Provincial Hospital, Jinan, Shandong, China

Treatment Trial of Subclinical Hypothyroidism in Down Syndrome

Not Applicable

Completed

Conditions: Subclinical Hypothyroidism
Down Syndrome

Interventions: Drug: Levothyroxine

First Posted Date: 2013-04-16

Last Posted Date: 2019-09-06

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 12

Registration Number: NCT01832753

Locations: 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States
🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

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