MedPath

Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Comparison of Two Pain-treatment Techniques After Cesarean Section

Phase 4
Completed
Conditions
Cesarean Section
Neuropathic Pain
Pain Management
Interventions
Procedure: TAP (transversus abdominis plane block)
Procedure: QL (quadratus lumborum block)
Drug: Bupivacaine
Device: Needle
Drug: Paracetamol
Drug: Metamizol
Drug: Ketoprofen
Drug: Morphine
First Posted Date
2016-06-17
Last Posted Date
2023-11-28
Lead Sponsor
Michał Borys
Target Recruit Count
232
Registration Number
NCT02804126
Locations
🇵🇱

II Department of Anesthesia and Intensive Care, Lublin, Poland

A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB)

Phase 1
Terminated
Conditions
Hepatitis B
Interventions
Drug: ARC-521 Injection
Other: Placebo
Drug: antihistamine
Drug: acetaminophen
Drug: entecavir
Drug: tenofovir
First Posted Date
2016-06-13
Last Posted Date
2018-09-25
Lead Sponsor
Arrowhead Pharmaceuticals
Target Recruit Count
47
Registration Number
NCT02797522
Locations
🇳🇿

Auckland Clinical Studies Ltd, Grafton, Auckland, New Zealand

Randomized Clinical Trial to Compare the Treatment of Mild Acute Diverticulitis With or Without Antibiotics

Phase 4
Completed
Conditions
Acute Diverticulitis
Interventions
Drug: Ibuprofen
Drug: Acetaminophen
Drug: Amoxicillin/clavulanic acid
First Posted Date
2016-05-30
Last Posted Date
2020-05-14
Lead Sponsor
Corporacion Parc Tauli
Target Recruit Count
480
Registration Number
NCT02785549
Locations
🇪🇸

Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain

Ketamine in Colorectal Surgery

Phase 4
Withdrawn
Conditions
Pain, Postoperative
Acute Pain
Colorectal Surgery
Interventions
First Posted Date
2016-05-27
Last Posted Date
2017-10-26
Lead Sponsor
Medical College of Wisconsin
Registration Number
NCT02785003
Locations
🇺🇸

Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin, United States

Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery

Phase 4
Completed
Conditions
Obesity, Morbid
Bariatric Surgery Candidate
Interventions
First Posted Date
2016-05-20
Last Posted Date
2018-03-14
Lead Sponsor
Inonu University
Target Recruit Count
40
Registration Number
NCT02778958
Locations
🇹🇷

Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation, Malatya, Turkey

Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department

Phase 4
Conditions
Sciatica
Interventions
First Posted Date
2016-05-19
Last Posted Date
2016-07-15
Lead Sponsor
Pamukkale University
Target Recruit Count
120
Registration Number
NCT02777320
Locations
🇹🇷

Pamukkale University, Denizli, Turkey

Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient

Completed
Conditions
Sepsis and Septic Shock
First Posted Date
2016-04-25
Last Posted Date
2019-07-18
Lead Sponsor
Università Politecnica delle Marche
Target Recruit Count
50
Registration Number
NCT02750163
Locations
🇮🇹

AOU Ospedali Riuniti Ancona - Università Politecnica delle Marche, Ancona, Italy

Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction

First Posted Date
2016-04-22
Last Posted Date
2017-08-02
Lead Sponsor
Foisor Orthopedics Clinical Hospital
Target Recruit Count
90
Registration Number
NCT02749162
Locations
🇷🇴

Foisor Orthopedics Clinical Hospital, Bucharest, Romania

Acetaminophen Randomized Controlled Trial

Phase 3
Withdrawn
Conditions
Post Operative Pain
Interventions
Other: Placebo
Drug: Acetaminophen
First Posted Date
2016-04-13
Last Posted Date
2018-07-26
Lead Sponsor
NYU Langone Health
Registration Number
NCT02737124
Locations
🇺🇸

New York University Medical Center, New York, New York, United States

Behavioral Expressions in Alzheimer's Disease

Completed
Conditions
Alzheimer's Disease
Interventions
Drug: Acetaminophen
Other: Placebo
First Posted Date
2016-03-25
Last Posted Date
2018-03-02
Lead Sponsor
University of Florida
Target Recruit Count
4
Registration Number
NCT02719834
Locations
🇺🇸

Oak Hammock Continuing Care Retirement Faculty, Gainesville, Florida, United States

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