Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Intravenous Acetaminophen Use With Bariatric Surgery on Morbidly Obese Patients

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2012-02-07
Last Posted Date
2015-12-17
Lead Sponsor
Trinity Health Of New England
Target Recruit Count
34
Registration Number
NCT01527942
Locations
🇺🇸

Saint Francis Hospital, Hartford, Connecticut, United States

Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy

First Posted Date
2012-02-06
Last Posted Date
2014-02-21
Lead Sponsor
G.Gennimatas General Hospital
Target Recruit Count
70
Registration Number
NCT01526525
Locations
🇬🇷

G.Gennimatas GENERAL HOSPITAL OF THESSALONIKI, Thessaloniki, Greece

A Relative Bioavailability Study of Acetaminophen Extended Release Gel Tabs 650 mg Under Fasting Condition

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2012-02-01
Last Posted Date
2012-02-09
Lead Sponsor
Ranbaxy Laboratories Limited
Target Recruit Count
32
Registration Number
NCT01523080
Locations
🇮🇳

Clinical Pharmacology Unit, Majeedia Hospital (2nd Floor), New Delhi, India

Effect of Liraglutide on Absorption of Paracetamol in Subjects With Type 2 Diabetes

First Posted Date
2012-01-25
Last Posted Date
2017-01-26
Lead Sponsor
Novo Nordisk A/S
Target Recruit Count
18
Registration Number
NCT01517555
Locations
🇩🇪

Novo Nordisk Investigational Site, Neuss, Germany

A Relative Bioavailability Study of Acetaminophen Extended Release Gel Tabs 650 mg Under Fed Condition

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2012-01-20
Last Posted Date
2012-01-31
Lead Sponsor
Ranbaxy Laboratories Limited
Target Recruit Count
40
Registration Number
NCT01513668
Locations
🇮🇳

Clinical Pharmacology Unit, B-22, Sector 62, Noida, Uttar Pradesh, India

Autologous Stem Cells in Osteoarthritis

First Posted Date
2011-12-05
Last Posted Date
2016-03-01
Lead Sponsor
Hospital Universitario Dr. Jose E. Gonzalez
Target Recruit Count
61
Registration Number
NCT01485198
Locations
🇲🇽

Traumatology Service, Monterrey, Nuevo Leon, Mexico

🇲🇽

Hematology Service, Monerrey, Nuevo Leon, Mexico

A Pharmacokinetic Study Investigating the Rate and Extent of Paracetamol Absorption of Three Experimental Sustained Release Pediatric Suspensions

First Posted Date
2011-11-22
Last Posted Date
2014-11-24
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
18
Registration Number
NCT01476215
Locations
🇺🇸

MDS Pharma Services NEBRASKA, Lincoln, Nebraska, United States

Intravenous Acetaminophen for Craniotomy Patients

Phase 2
Conditions
Interventions
First Posted Date
2011-11-18
Last Posted Date
2016-09-29
Lead Sponsor
Swedish Medical Center
Target Recruit Count
80
Registration Number
NCT01474304
Locations
🇺🇸

Swedish Medical Center Cherry Hill Campus, Seattle, Washington, United States

Efficacy of Intravenous (IV) Paracetamol for Treatment of Acute Pain

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-11-06
Last Posted Date
2012-12-10
Lead Sponsor
Tehran University of Medical Sciences
Target Recruit Count
60
Registration Number
NCT01465984
Locations
🇮🇷

TUMS, Tehran, Iran, Islamic Republic of

Effects of a Common Cold Treatment on Cognitive Function

Phase 4
Completed
Conditions
Interventions
First Posted Date
2011-11-06
Last Posted Date
2013-11-25
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
72
Registration Number
NCT01466348
Locations
🇬🇧

Common Cold Centre, Cardiff, Wales, United Kingdom

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