Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)

Phase 1

Completed

Conditions: Osteoarthritis

Interventions: Drug: Naproxen
Drug: Placebo
Drug: Ultracet

First Posted Date: 2008-10-15

Last Posted Date: 2015-11-20

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 22

Registration Number: NCT00772967

Randomized Trial for Mixed Acute Rejection

Phase 2

Completed

Conditions: Graft Rejection

Interventions: Drug: Rabbit Antithymocyte Globulin (RATG)
Drug: Rituximab
Drug: Antihistamine
Drug: Bortezomib
Drug: Acetaminophen
Drug: Methylprednisolone

First Posted Date: 2008-10-15

Last Posted Date: 2016-01-27

Lead Sponsor: University of Cincinnati

Target Recruit Count: 30

Registration Number: NCT00771875

Locations: 🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States
🇺🇸
The Christ Hospital, Cincinnati, Ohio, United States

Effect of Race/Ethnicity and Genes on Acetaminophen Pharmacokinetics

Phase 4

Completed

Conditions: Hepatotoxicity
Pain
Fever

Interventions: Drug: Acetaminophen

First Posted Date: 2008-10-08

Last Posted Date: 2019-05-23

Lead Sponsor: Tufts University

Target Recruit Count: 95

Registration Number: NCT00768716

Locations: 🇺🇸
Tufts Clinical Pharmacology Study Unit, Boston, Massachusetts, United States

An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain

Phase 4

Completed

Conditions: Pain
Fibromyalgia

Interventions: Drug: Tramadol hydrochloride
Drug: Acetaminophen

First Posted Date: 2008-10-06

Last Posted Date: 2013-07-03

Lead Sponsor: Johnson & Johnson Taiwan Ltd

Target Recruit Count: 80

Registration Number: NCT00766675

Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

Not Applicable

Completed

Conditions: Platelet Aggregation

Interventions: Drug: Parecoxib/Valdecoxib
Drug: dipyrone
Drug: Ibuprofen
Drug: Acetaminophen
Other: Blood samples

First Posted Date: 2008-10-01

Last Posted Date: 2008-10-01

Lead Sponsor: Ruhr University of Bochum

Target Recruit Count: 80

Registration Number: NCT00763997

Locations: 🇩🇪
BG University Hospital Bergmannsheil GmbH, Bochum, Germany

Aminotransferase Trends During Prolonged Acetaminophen Dosing

Phase 4

Completed

Conditions: Drug Toxicity
Healthy

Interventions: Drug: acetaminophen
Drug: placebo

First Posted Date: 2008-08-28

Last Posted Date: 2013-09-18

Lead Sponsor: Denver Health and Hospital Authority

Target Recruit Count: 398

Registration Number: NCT00743093

Locations: 🇺🇸
University of Colorado Health Sciences Center - GCRC, Aurora, Colorado, United States
🇺🇸
Denver Health Rocky Mountain Poison and Drug Center, Denver, Colorado, United States