Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film...

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine Versus Ketofol for Moderate Sedation in Endoscopic Retrograde Cholangiopancreatography

Phase 4

Completed

Conditions: Sedation

Interventions: Drug: Ketofole
Drug: Dexmedetomidine

First Posted Date: 2024-01-18

Last Posted Date: 2024-01-18

Lead Sponsor: Sindh Institute of Urology and Transplantation

Target Recruit Count: 62

Registration Number: NCT06212401

Locations: 🇵🇰
Sindh Institute of Urology and Transplantation, Karachi, Sindh, Pakistan

A Low Dose Dexmedetomidine in Sedation Colonoscopy

Not Applicable

Not yet recruiting

Conditions: Colonoscopy

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2024-01-17

Last Posted Date: 2024-01-17

Lead Sponsor: West China Hospital

Target Recruit Count: 104

Registration Number: NCT06208956

The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

Not Applicable

Recruiting

Conditions: Mechanical Ventilation Complication
Respiratory Failure
Critical Illness
Lung Injury
Respiratory Distress Syndrome, Adult

Interventions: Procedure: Titrating sedation targeting both optimal P0.1 and appropriate arousal level
Drug: Fentanyl
Drug: Midazolam
Drug: Propofol
Drug: Dexmedetomidine
Drug: Cisatracurium

First Posted Date: 2024-01-12

Last Posted Date: 2024-01-12

Lead Sponsor: Siriraj Hospital

Target Recruit Count: 214

Registration Number: NCT06203405

Locations: 🇹🇭
Siriraj Hospital, Bangkok, Thailand

Dexmedetomidine Versus Fentanyl on Postoperative Analgesic Profile in Laparoscopic Sleeve Gastrectomy

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Dexmedetomidine
Drug: Fentanyl

First Posted Date: 2024-01-02

Last Posted Date: 2024-01-02

Lead Sponsor: Helwan University

Target Recruit Count: 64

Registration Number: NCT06186895

Locations: 🇪🇬
Ryad Ghoraba, Tanta, Gharbia, Egypt

Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy

Phase 3

Completed

Conditions: Diagnosis
Lung Diseases
Anesthesia

Interventions: Drug: Midazolam
Drug: Dexmedetomidine
Drug: Ketamine
Drug: Fentanyl

First Posted Date: 2023-12-29

Last Posted Date: 2023-12-29

Lead Sponsor: University of Patras

Target Recruit Count: 50

Registration Number: NCT06185127

Locations: 🇬🇷
Naval Hospital, Athens, Attica, Greece

Caudal Block With Bupivacaine and Dexmedetomidine Versus TAP Block With Bupivacaine Alone for Postoperative Analgesia in Pediatric Undergoing Infraumbical Surgeries

Phase 2

Recruiting

Conditions: Postoperative Pain

Interventions: Procedure: caudal block
Procedure: TAP
Drug: Dexmedetomidine
Drug: Bupivacain

First Posted Date: 2023-12-27

Last Posted Date: 2023-12-27

Lead Sponsor: Sohag University

Target Recruit Count: 90

Registration Number: NCT06183073

Locations: 🇪🇬
Fouad Ibrahim Soliman, Sohag, Egypt

Intranasal Dexmedetomidine Versus Intranasal Midazolam as a Premedication in Pediatrics Undergoing Upper GI Endoscopy

Phase 4

Not yet recruiting

Conditions: Anesthesia

Interventions: Drug: Dexmedetomidine
Drug: Midazolam

First Posted Date: 2023-12-26

Last Posted Date: 2023-12-26

Lead Sponsor: Ain Shams University

Target Recruit Count: 70

Registration Number: NCT06181682

Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors

Not Applicable

Not yet recruiting

Conditions: Postoperative Delirium

Interventions: Drug: Dexmedetomidine

First Posted Date: 2023-12-11

Last Posted Date: 2024-01-16

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 222

Registration Number: NCT06164314

Locations: 🇨🇳
Beijing Tiantan Hospital, Beijing, China

Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia

Phase 2

Conditions: Familial Dysautonomia

Interventions: Drug: Dexmedetomidine
Drug: Matching placebo

First Posted Date: 2023-11-28

Last Posted Date: 2024-07-26

Lead Sponsor: NYU Langone Health

Target Recruit Count: 15

Registration Number: NCT06148311

Locations: 🇺🇸
NYU Langone Health, New York, New York, United States

The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

Recruiting

Conditions: Brain Network Connectivity
Dexmedetomidine
Propofol
Postoperative Delirium

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2023-11-18

Last Posted Date: 2023-11-18

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 120

Registration Number: NCT06138340

Locations: 🇨🇳
Beijing Tian Tan Hospital, Capital Medical University, Beijing, Beijing, China

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