Dexmedetomidine
- Generic Name
- Dexmedetomidine
- Brand Names
- Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2
- CAS Number
- 113775-47-6
- Unique Ingredient Identifier
- 67VB76HONO
- Background
An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.
- Indication
Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.
- Associated Conditions
- Agitation, Alcohol Withdrawal Syndrome
Addition of Dexmedetomidine to Ropivacaine in Bilateral Erector Spinae Plane Block in Patients Undergoing Coronary Artery Bypass Surgery
- Conditions
- PainPain Management Following Cardiopulmonary Bypass SurgeryErector Spinae Plane Block
- Interventions
- First Posted Date
- 2025-05-21
- Last Posted Date
- 2025-05-21
- Lead Sponsor
- Lebanese American University
- Target Recruit Count
- 110
- Registration Number
- NCT06981949
Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries
- Conditions
- Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY
- Interventions
- Drug: Dexmedetomidine and ketamine ( Ketodex )
- First Posted Date
- 2025-05-20
- Last Posted Date
- 2025-05-20
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 84
- Registration Number
- NCT06981494
- Locations
- 🇪🇬
Faculty of medicine, Sohag, Egypt
Efficacy of Intraoperative Magnesium Sulphate vs Dexmedetomidine on Emergence Agitation in Pediatric Patients
- Conditions
- Magnesium SulphateDexmedetomidineEmergence AgitationPediatric Patients
- Interventions
- First Posted Date
- 2025-05-18
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT06977425
- Locations
- 🇪🇬
Ain shams university, Cairo, Egypt
Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia
- Conditions
- Cough
- Interventions
- First Posted Date
- 2025-05-18
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- Al-Azhar University
- Target Recruit Count
- 300
- Registration Number
- NCT06979141
Infusion of Dexmedetomidine Versus Lidocaine in Management of Acute Postoperative Pain After Modified Radical Mastectomy
- Conditions
- InfusionPostoperative PainDexmedetomidineLidocaineAcuteModified Radical Mastectomy
- Interventions
- First Posted Date
- 2025-05-16
- Last Posted Date
- 2025-05-16
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 40
- Registration Number
- NCT06974656
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Combining Dexmedetomidine Infusion and Paragastric Autonomic Neural Block to Enhance Postoperative Recovery in Patients Undergoing Laparoscopic Sleeve Gastrectomy
- Conditions
- Laparoscopic Sleeve Gastrectomy (LSG)
- Interventions
- Procedure: paragastric autonomic neural block
- First Posted Date
- 2025-05-14
- Last Posted Date
- 2025-05-14
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 46
- Registration Number
- NCT06970678
- Locations
- 🇪🇬
Alexandria Main University Hospital, Alexandria, Egypt
Quality of Recovery in Laparoscopic Sleeve Gastrectomy Using Dexmedetomidine Infusion Versus Laparoscopic TAP Block in Combination With Paragastric Neural Block
- Conditions
- Laparoscopic Sleeve Gastrectomy
- Interventions
- Procedure: Paragastric neural blockProcedure: Laparoscopic Transversus Abdominis Plane (LTAP) block
- First Posted Date
- 2025-05-14
- Last Posted Date
- 2025-05-14
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 60
- Registration Number
- NCT06970626
- Locations
- 🇪🇬
Alexandria Main University Hospital, Alexandria, Egypt
Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
- Conditions
- Aki After Ascending Aortic Surgeries
- Interventions
- Drug: Normal Saline (Placebo)
- First Posted Date
- 2025-05-06
- Last Posted Date
- 2025-05-07
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 78
- Registration Number
- NCT06958367
- Locations
- 🇪🇬
AIN shams university, Cairo, Egypt
Ultrasound vs. Surgical ESP Block With Bupivacaine-Dexmedetomidine in Lumbar Fusion Surgery
- Conditions
- Post Operative Pain
- Interventions
- Procedure: Ultrasound Guided erector spinae plane block (UB)Procedure: Surgical erector spinae plane block (SB)
- First Posted Date
- 2025-05-06
- Last Posted Date
- 2025-05-07
- Lead Sponsor
- Fayoum University Hospital
- Target Recruit Count
- 52
- Registration Number
- NCT06958718
- Locations
- 🇪🇬
Fayoum University hospital, Fayoum, Fayoum Governorate, Egypt
Effect of Dexmedetomidine on Hemodynamics in Cardiac Surgery
- Conditions
- Use of Dexmedetomidine in Cardiac Surgery (CABG, Valve Replacement or Total Aortic Arch Replacement)
- Interventions
- First Posted Date
- 2025-05-06
- Last Posted Date
- 2025-05-06
- Lead Sponsor
- Pamukkale University
- Target Recruit Count
- 52
- Registration Number
- NCT06958913
- Locations
- 🇹🇷
Pamukkale University, Denizli, Turkey
Drug Development Updates
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