Dexmedetomidine
- Generic Name
- Dexmedetomidine
- Brand Names
- Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2
- CAS Number
- 113775-47-6
- Unique Ingredient Identifier
- 67VB76HONO
- Background
An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.
- Indication
Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.
- Associated Conditions
- Agitation, Alcohol Withdrawal Syndrome
Comparison of Oral Dexmedetomidine, Ketamine Versus Midazolam for Premedication in Children Undergoing Injuinal Surgeries
- Conditions
- AnesthesiaPediatric
- Interventions
- First Posted Date
- 2025-03-17
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 60
- Registration Number
- NCT06879496
- Locations
- 🇪🇬
Mohamed Zakarea Wfa, Tanta, Egypt
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
- Conditions
- PreTerm NeonateSedation for Invasive Mechanical VentilationVery Preterm Neonates with Sedation for Invasive Mechanical Ventilation
- Interventions
- First Posted Date
- 2025-03-17
- Last Posted Date
- 2025-03-17
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 380
- Registration Number
- NCT06878703
- Locations
- 🇫🇷
Hospital Armand Trousseau, APHP Service : Department of Neonatology, Paris, France
Dexmedetomidine Versus Magnesium Sulfate as Adjuvants to Intraperitoneal Bupivacaine for Postoperative Analgesia After Elective Laparoscopic Cholecystectomy
- Conditions
- DexmedetomidineMagnesium SulfateAdjuvantsIntraperitoneal BupivacainePostoperative AnalgesiaElective Laparoscopic Cholecystectomy
- Interventions
- First Posted Date
- 2025-03-17
- Last Posted Date
- 2025-03-17
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 75
- Registration Number
- NCT06879288
- Locations
- 🇪🇬
Tanta University, Tanta, El-Gharbia, Egypt
Dexmedetomidine and Agitation After Nasal Surgery
- Conditions
- Nasal DiseaseAgitation, Emergence
- Interventions
- First Posted Date
- 2025-03-10
- Last Posted Date
- 2025-03-10
- Lead Sponsor
- Fayoum University Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT06867302
- Locations
- 🇪🇬
Fayoum University Hospital, Fayoum, Faiyum, Egypt
Dexmedetomidine Infusion in Either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
- Conditions
- Rhinosinusitis
- Interventions
- Procedure: functional endoscopic sinus surgery
- First Posted Date
- 2025-03-10
- Last Posted Date
- 2025-03-10
- Lead Sponsor
- Menoufia University
- Target Recruit Count
- 50
- Registration Number
- NCT06866145
- Locations
- 🇪🇬
Menoufia university hospital, Shibin Elkom, Egypt
Comparing Efficacy of Intravenous Dexmedetomidine and Lidocaine on Postoperative Analgesia in Patients Undergoing Fracture Hip Surgery
- Conditions
- Fracture Hip Surgery
- Interventions
- First Posted Date
- 2025-03-07
- Last Posted Date
- 2025-03-07
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 56
- Registration Number
- NCT06865469
Brain Tumor Surgery and Postoperative Delirium
- Conditions
- Brain Tumor
- Interventions
- Drug: Normal Saline
- First Posted Date
- 2025-03-07
- Last Posted Date
- 2025-03-07
- Target Recruit Count
- 140
- Registration Number
- NCT06863064
- Locations
- 🇨🇳
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
- Conditions
- Preoperative AnxietyPreoperative SedationChildrenDexmedetomidineEsketamineED95ED50Preoperative Sedation of Children
- Interventions
- First Posted Date
- 2025-03-03
- Last Posted Date
- 2025-03-10
- Lead Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06853431
- Locations
- 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen Saturation
- Conditions
- Cerebral Desaturation EventsSpine Surgeries
- Interventions
- First Posted Date
- 2025-02-27
- Last Posted Date
- 2025-02-27
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 90
- Registration Number
- NCT06848595
Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
- Conditions
- LidocaineInfusionDexmedetomidineIntraoperative BleedingFunctional Endoscopic Sinus Surgery
- Interventions
- First Posted Date
- 2025-02-27
- Last Posted Date
- 2025-03-05
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 40
- Registration Number
- NCT06848764
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Drug Development Updates
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