Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
Colchicine Counteracting Inflammation in COVID-19 Pneumonia
- First Posted Date
- 2020-03-26
- Last Posted Date
- 2022-07-20
- Lead Sponsor
- Azienda Ospedaliero-Universitaria di Parma
- Target Recruit Count
- 193
- Registration Number
- NCT04322565
- Locations
- 🇮🇹
Azienda Ospedaliero Universitaria di Parma, Parma, PR, Italy
Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA)
- Conditions
- Interventions
- First Posted Date
- 2020-03-26
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Montreal Heart Institute
- Target Recruit Count
- 4506
- Registration Number
- NCT04322682
- Locations
- 🇺🇸
Mayo Clinic - Rochester, Rochester, Minnesota, United States
🇺🇸South Florida Research Organization, Medley, Florida, United States
🇺🇸Baylor Scott & White Research Institute - Pharmacy, Dallas, Texas, United States
Effect of Colchicine in Patients With Myocardial Infarction
- Conditions
- Interventions
- First Posted Date
- 2020-01-06
- Last Posted Date
- 2023-04-12
- Lead Sponsor
- Shifa Tameer-e-Millat University
- Registration Number
- NCT04218786
- Locations
- 🇵🇰
Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan
PET Imaging of Inflammation and Lipid Lowering Study
- Conditions
- Interventions
- First Posted Date
- 2019-08-29
- Last Posted Date
- 2024-07-19
- Lead Sponsor
- University of Cambridge
- Target Recruit Count
- 63
- Registration Number
- NCT04073797
- Locations
- 🇬🇧
University of Cambridge, Cambridge, United Kingdom
Atorvastatin vs Colchicine in Decrease of Troponin I of High Sensitivity in Patients With Rheumatoid Arthritis.
- Conditions
- Interventions
- First Posted Date
- 2019-08-14
- Last Posted Date
- 2019-08-14
- Lead Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
- Target Recruit Count
- 60
- Registration Number
- NCT04056039
- Locations
- 🇲🇽
Hospital Central "Dr Ignacio Morones Prieto", San Luis Potosí, Mexico
Efficacy of Colchicine to Prevent Skin Relapses in Adult's IgA Vasculitis
- First Posted Date
- 2019-07-05
- Last Posted Date
- 2021-10-04
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 264
- Registration Number
- NCT04008316
- Locations
- 🇫🇷
Saint Louis Hospital, Paris, France
Prophylaxis Against Postoperative Atrial Fibrillation in Patients Undergoing On-pump CABG
- Conditions
- Interventions
- First Posted Date
- 2019-04-05
- Last Posted Date
- 2019-04-05
- Lead Sponsor
- doaa rashwan
- Target Recruit Count
- 48
- Registration Number
- NCT03905759
- Locations
- 🇪🇬
Faculty Of Medicine, Beni-Suef University, Banī Suwayf, Egypt
Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers
- Conditions
- Interventions
- First Posted Date
- 2019-03-25
- Last Posted Date
- 2023-08-03
- Lead Sponsor
- Ipekyolu Ilac Ltd. Sti
- Target Recruit Count
- 41
- Registration Number
- NCT03888846
- Locations
- 🇹🇷
Istanbul Universitesi-Cerrahpaşa Tıp Fakültesi, İç Hastalıkları Anabilim Dalı-Romatoloji, Istanbul, Turkey
Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR
- Conditions
- Interventions
- First Posted Date
- 2018-09-06
- Last Posted Date
- 2018-11-27
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 400
- Registration Number
- NCT03659058
Colchicine in Postoperative Fontan Patients
- First Posted Date
- 2018-07-02
- Last Posted Date
- 2022-05-09
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 11
- Registration Number
- NCT03575572
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.