Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)
- Conditions
- Interventions
- First Posted Date
- 2017-10-16
- Last Posted Date
- 2023-08-07
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 3209
- Registration Number
- NCT03310125
- Locations
- 🇺🇸
The Ohio State University Wexner Medical Center, Columbus, Ohio, United States
🇺🇸Cleveland Clinic Florida, Weston, Florida, United States
🇺🇸Stony Brook University Hospital, Stony Brook, New York, United States
A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment
- Conditions
- Interventions
- First Posted Date
- 2017-07-24
- Last Posted Date
- 2021-11-04
- Lead Sponsor
- Ironwood Pharmaceuticals, Inc.
- Target Recruit Count
- 242
- Registration Number
- NCT03226899
- Locations
- 🇺🇸
Four Rivers Clinical Research, Paducah, Kentucky, United States
🇺🇸Southern Arizona VA Health Care System, Tucson, Arizona, United States
🇭🇺Dr Lakatos Ferenc Belgyogyaszati-Kardiologiai Maganrendelo, Békéscsaba, Hungary
The Drug-Drug Interaction of SHR4640, Febuxostat and Colchicine in Patients With Gout
- First Posted Date
- 2017-04-27
- Last Posted Date
- 2019-08-08
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 15
- Registration Number
- NCT03131583
- Locations
- 🇨🇳
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry
- First Posted Date
- 2017-02-09
- Last Posted Date
- 2024-10-14
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 7264
- Registration Number
- NCT03048825
- Locations
- 🇺🇸
Central Cardiology, Bakersfield, California, United States
🇺🇸Medstar Washington Hospital Center, Washington, District of Columbia, United States
🇺🇸University of Illinois, Chicago, Illinois, United States
Effect of Colchicine on the Incidence of Atrial Fibrillation in Open Heart Surgery Patients
- First Posted Date
- 2017-01-13
- Last Posted Date
- 2018-01-23
- Lead Sponsor
- Jordan Collaborating Cardiology Group
- Target Recruit Count
- 360
- Registration Number
- NCT03021343
Effect of Low Dose ColchiciNe on the InciDence of POAF
- Conditions
- Interventions
- First Posted Date
- 2017-01-10
- Last Posted Date
- 2020-05-01
- Lead Sponsor
- Jordan Collaborating Cardiology Group
- Target Recruit Count
- 254
- Registration Number
- NCT03015831
- Locations
- 🇯🇴
Istishari Hospital, Amman, Jordan
🇯🇴Jordan Hospital, Amman, Jordan
🇯🇴Khalidi Hospital & Medical Center, Amman, Jordan
A Randomized Multicenter Study for Isolated Skin Vasculitis
- Conditions
- Interventions
- First Posted Date
- 2016-10-20
- Last Posted Date
- 2024-02-01
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 90
- Registration Number
- NCT02939573
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸Boston University School of Medicine, Boston, Massachusetts, United States
🇺🇸Penn State Hershey Medical Center, Hershey, Pennsylvania, United States
Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement
- First Posted Date
- 2016-10-06
- Last Posted Date
- 2020-07-28
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 112
- Registration Number
- NCT02926248
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke
- First Posted Date
- 2016-09-13
- Last Posted Date
- 2024-06-17
- Lead Sponsor
- University College Dublin
- Target Recruit Count
- 3154
- Registration Number
- NCT02898610
- Locations
- 🇧🇪
Uza, Antwerpen, Antwerp, Belgium
🇩🇪Vivantes Humboldt-Klinikum, Berlin, Germany
🇧🇪UCL, Brussels, Brussels, Belgium
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIV
- Conditions
- Interventions
- First Posted Date
- 2015-12-08
- Last Posted Date
- 2021-10-21
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 81
- Registration Number
- NCT02624180
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Drug Development Updates
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