Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF
- First Posted Date
- 2015-11-11
- Last Posted Date
- 2015-11-11
- Target Recruit Count
- 79
- Registration Number
- NCT02602028
- Locations
- 🇹🇷
FMF Arthritis Vasculitis and Orphan Disease Research in Paediatric Rheumatology (FAVOR), Ankara, Turkey
Colchicine Cardiovascular Outcomes Trial (COLCOT)
- Conditions
- Interventions
- First Posted Date
- 2015-09-16
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- Montreal Heart Institute
- Target Recruit Count
- 4745
- Registration Number
- NCT02551094
- Locations
- 🇨🇦
Montreal Heart Institute, Montreal, Quebec, Canada
Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout
- Conditions
- Interventions
- First Posted Date
- 2015-07-16
- Last Posted Date
- 2019-06-21
- Lead Sponsor
- Menarini International Operations Luxembourg SA
- Target Recruit Count
- 196
- Registration Number
- NCT02500641
- Locations
- 🇵🇱
Specjalistyczna Praktyka Lekarska Piotr Kubalski, Grudziądz, Poland
🇵🇱Oddział Kardiologiczny, WSS im. W. Biegańskiego w Łodzi, Łódź, Poland
🇷🇴S.C. Cardiomed S.R.L., Craiova, Romania
Colchicine for Diabetic Nephropathy Trial
- First Posted Date
- 2015-05-13
- Last Posted Date
- 2017-05-09
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT02442921
- Locations
- 🇮🇱
Sheba Medical Center, Ramat Gan, Israel
Inflammation and Coronary Endothelial Function
- Conditions
- Interventions
- First Posted Date
- 2015-02-19
- Last Posted Date
- 2021-10-21
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 111
- Registration Number
- NCT02366091
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Bucillamine for the Treatment of Acute Gout Flare in Subjects With Moderate to Severe Gout
- First Posted Date
- 2015-01-05
- Last Posted Date
- 2016-10-05
- Lead Sponsor
- Revive Therapeutics, Ltd.
- Target Recruit Count
- 66
- Registration Number
- NCT02330796
- Locations
- 🇺🇸
Texas Physicians Research Medical Group, Arlington, Texas, United States
🇺🇸West Coast Research, San Roman, California, United States
🇺🇸Sun Research Institute, San Antonio, Texas, United States
Colchicine in Atrial Fibrillation to Prevent Stroke
- First Posted Date
- 2014-11-04
- Last Posted Date
- 2021-02-23
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 80
- Registration Number
- NCT02282098
- Locations
- 🇨🇦
Hamilton General Hospital, Hamilton, Ontario, Canada
Post-MI PET Scan Imaging of Inflammation
- First Posted Date
- 2014-11-02
- Last Posted Date
- 2014-11-02
- Lead Sponsor
- G.Gennimatas General Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT02281305
- Locations
- 🇬🇷
Athens General Hospital "G. Gennimatas", Athens, Attika, Greece
Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion
- First Posted Date
- 2014-10-09
- Last Posted Date
- 2024-04-23
- Lead Sponsor
- Yong Seog Oh
- Target Recruit Count
- 20
- Registration Number
- NCT02260206
- Locations
- 🇰🇷
Seoul St Mary's Hospital, Seoul, Seo Cho Gu, Korea, Republic of
Evaluate the PK, PD, and Safety of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Patients With Gout
- Conditions
- Interventions
- First Posted Date
- 2014-09-30
- Last Posted Date
- 2015-04-17
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 32
- Registration Number
- NCT02252835
- Locations
- 🇺🇸
Vince & Associates Clinical Research, Overland Park, Kansas, United States
Drug Development Updates
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