Colchicine
- Generic Name
- Colchicine
- Brand Names
- Colcrys, Gloperba, Lodoco, Mitigare
- Drug Type
- Small Molecule
- Chemical Formula
- C22H25NO6
- CAS Number
- 64-86-8
- Unique Ingredient Identifier
- SML2Y3J35T
- Background
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammato...
- Indication
Colchicine is indicated for the prophylaxis and treatment of gout flares. It is also indicated in Familial Mediterranean fever (FMF) in children and adults of four years of age and older. It is also indicated to reduce the risk of myocardial infarction (MI), stroke, coronary revascularization, and cardiovascular death in adult patients with established ather...
- Associated Conditions
- Behcet's Syndrome, Cardiovascular Mortality, Coronary Revascularization, Familial Mediterranean Fever (FMF ), Gout Flares, Myocardial Infarction, Pericarditis, Postpericardiotomy Syndrome, Stroke
- Associated Therapies
- -
Effect of Colchicine for the Palliative Management of Hepatocellular Carcinoma
- First Posted Date
- 2013-09-05
- Last Posted Date
- 2020-08-19
- Target Recruit Count
- 15
- Registration Number
- NCT01935700
- Locations
- 🇨🇳
Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Colchicine for Acute Coronary Syndromes
- First Posted Date
- 2013-07-24
- Last Posted Date
- 2013-07-24
- Lead Sponsor
- Maria Vittoria Hospital
- Target Recruit Count
- 500
- Registration Number
- NCT01906749
- Locations
- 🇮🇹
Cardiology Dpt.Maria Vittoria Hospital, Torino, Italy
🇮🇹Cardiology Dpt.San Giovanni Bosco Hospital, Torino, Italy
🇮🇹Cardiology Dpt., Rivoli, Torino, Italy
Anti-inflammatory Effects of Colchicine in PCI
- First Posted Date
- 2012-10-18
- Last Posted Date
- 2022-05-25
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 280
- Registration Number
- NCT01709981
- Locations
- 🇺🇸
Bellevue Hospital Center, New York, New York, United States
🇺🇸Manhattan VA Hospital, New York, New York, United States
🇺🇸New York Langone Medical Center, New York, New York, United States
Drug Interaction Study of Colchicine and Theophylline
- First Posted Date
- 2012-05-17
- Last Posted Date
- 2013-06-17
- Lead Sponsor
- Takeda
- Target Recruit Count
- 30
- Registration Number
- NCT01601132
- Locations
- 🇺🇸
Worlwide Clinical Trials Drug Development Solutions, Clinical Research Services, San Antonio, Texas, United States
COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial)
- First Posted Date
- 2012-03-13
- Last Posted Date
- 2014-07-01
- Lead Sponsor
- Maria Vittoria Hospital
- Target Recruit Count
- 360
- Registration Number
- NCT01552187
- Locations
- 🇮🇹
Cardiology Dpt. Maria Vittoria Hospital, Torino, Italy
Oral Colchicine in Men With Castrate Resistant Prostate Cancer
- First Posted Date
- 2011-11-29
- Last Posted Date
- 2013-09-27
- Lead Sponsor
- Milton S. Hershey Medical Center
- Registration Number
- NCT01481233
Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patients
- Conditions
- Interventions
- First Posted Date
- 2011-08-15
- Last Posted Date
- 2015-04-03
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 27
- Registration Number
- NCT01416402
Safety/Efficacy Study to Evaluate of MBX-102 in Combination With Allopurinol in Gout Patients
- Conditions
- Interventions
- First Posted Date
- 2011-07-21
- Last Posted Date
- 2015-09-18
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 100
- Registration Number
- NCT01399008
Safety and Efficacy Study of MBX-102 in Treatment of Hyperuricemia in Patients With Gout
- Conditions
- Interventions
- First Posted Date
- 2011-04-18
- Last Posted Date
- 2015-04-17
- Lead Sponsor
- CymaBay Therapeutics, Inc.
- Target Recruit Count
- 67
- Registration Number
- NCT01336686
A Pilot Study for PK/PD Parameter of Colchicine in Chronic Kidney Disease Patient.
- First Posted Date
- 2010-07-30
- Last Posted Date
- 2010-12-29
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT01173107
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Drug Development Updates
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