Metronidazole

Generic Name
Metronidazole
Brand Names
Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole
Drug Type
Small Molecule
Chemical Formula
C6H9N3O3
CAS Number
443-48-1
Unique Ingredient Identifier
140QMO216E
Background

Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.

Indication

Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, the heart, reproductive organs, central nervous system, and the respiratory system. Some may also be present in the bloodstream in cases of septicemia. Common infections treated by metronidazole are Bacteroides species infections, Clostridium infections, and Fusobacterium infections, as well as Peptococcus and Peptostreptococcus infections. Topical formulations of metronidazole are indicated for the treatment of inflammatory lesions of rosacea.

It is also used off-label in the treatment of Crohn's disease, as a prophylactic agent after surgery, and in the treatment of Helicobacter pylori infection. It has also been studied in the prevention of preterm births and to treat periodontal disease.

Associated Conditions
Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis
Associated Therapies
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Levofloxacin and Bismuth-containing Therapy Versus Quadruple Therapy as Second-line Treatment of Resistant Helicobacter Pylori Infection

First Posted Date
2012-12-05
Last Posted Date
2014-08-29
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
200
Registration Number
NCT01742429
Locations
🇨🇳

Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, Shanghai, China

Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections

First Posted Date
2012-11-14
Last Posted Date
2017-09-06
Lead Sponsor
Pfizer
Target Recruit Count
486
Registration Number
NCT01726023
Locations
🇻🇳

Research Site, Hochiminh, Vietnam

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies

First Posted Date
2012-11-07
Last Posted Date
2024-06-21
Lead Sponsor
HaEmek Medical Center, Israel
Target Recruit Count
750
Registration Number
NCT01722708
Locations
🇮🇱

Departement of obstetric and gynecology, Poriya Medical Center, Tiberias, Israel

🇮🇱

Departement of obstetric and gynecology, HaEmek medical center, Afula, Israel

Empirical Rescue Therapies of Helicobacter Pylori Infection

First Posted Date
2012-08-20
Last Posted Date
2013-06-04
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
424
Registration Number
NCT01668927
Locations
🇨🇳

Renji Hospital, Shanghai, Shanghai, China

Effects and Safety of Metronidazole in Patients With Gastrectomy

Phase 3
Withdrawn
Conditions
Interventions
First Posted Date
2012-08-07
Last Posted Date
2020-09-21
Lead Sponsor
The Catholic University of Korea
Registration Number
NCT01658852

Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens

First Posted Date
2012-07-19
Last Posted Date
2017-09-29
Lead Sponsor
Pfizer
Target Recruit Count
345
Registration Number
NCT01644643
Locations
🇺🇦

Research Site, Zaporizhzhya, Ukraine

Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease

First Posted Date
2012-05-11
Last Posted Date
2017-08-10
Lead Sponsor
Prof. Arie Levine
Target Recruit Count
73
Registration Number
NCT01596894
Locations
🇮🇱

The E. Wolfson.Medical Center, Holon, Israel

Adalimumab on Preventing Post-chirurgic Recurrence on Crohn´s Disease

First Posted Date
2012-03-28
Last Posted Date
2015-03-17
Lead Sponsor
Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Target Recruit Count
86
Registration Number
NCT01564823
Locations
🇪🇸

Hospital General Dr. Negrín, Las Palmas de Gran Canaria, Islas Canarias, Spain

🇪🇸

Hospital Reina Sofía, Córdoba, Spain

🇪🇸

Hospital Arquitecto Marcide, Ferrol, La Coruña, Spain

and more 19 locations

A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis

First Posted Date
2012-03-21
Last Posted Date
2013-06-07
Lead Sponsor
Dr. Reddy's Laboratories Limited
Target Recruit Count
60
Registration Number
NCT01559545
Locations
🇮🇳

Apex Medicical College, Jaipur, Rajasthan, India

🇮🇳

SKS Hospital India Pvt. Ltd., Salem, Tamil Nadu, India

🇮🇳

Meenakshi Mission Hospital and Research Center, Madurai, Tamil Nadu, India

and more 9 locations

A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately

First Posted Date
2012-02-16
Last Posted Date
2017-09-05
Lead Sponsor
Pfizer
Target Recruit Count
28
Registration Number
NCT01534247
Locations
🇺🇸

Research site, Overland Park, Kansas, United States

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